TGF-β signaling links E-cadherin loss to suppression of nucleotide excision repair.

E-cadherin is a cell adhesion molecule best known for its function in suppressing tumor progression and metastasis. Here we show that E-cadherin promotes nucleotide excision repair through positively regulating the expression of xeroderma pigmentosum complementation group C (XPC) and DNA damage-binding protein 1 (DDB1). Loss of E-cadherin activates the E2F4 and p130/107 transcription repressor complexes to suppress the transcription of both XPC and DDB1 through activating the transforming growth factor-β (TGF-β) pathway. Adding XPC or DDB1, or inhibiting the TGF-β pathway, increases the repair of ultraviolet (UV)-induced DNA damage in E-cadherin-inhibited cells. In the mouse skin and skin tumors, UVB radiation downregulates E-cadherin. In sun-associated premalignant and malignant skin neoplasia, E-cadherin is downregulated in association with reduced XPC and DDB1 levels. These findings demonstrate a crucial role of E-cadherin in efficient DNA repair of UV-induced DNA damage, identify a new link between epithelial adhesion and DNA repair and suggest a mechanistic link of early E-cadherin loss in tumor initiation

Comportamento a ferrugem da folha das cultivares de trigo recomendadas para o cultivo no RS em 1984.

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Resultados da XIª, XIIª, XIIIª e XIVª coleção para avaliação e coleta de ferrugem do colmo e ferrugem da folha do trigo 1998-2001.

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Reação à ferrugem da folha das cultivares de trigo recomendadas para o cultivo no RS e SC em 1983.

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Automação da semeadura de séries diferenciais no processo de identificação de raças de ferrugem da folha do trigo.

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Ensaios cooperativos - ferrugens do trigo cone sul da América do Sul 1980-1981.

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Tributação e a Organização dos Prestadores de Serviços no Brasil

The real impact of taxes on the economy can only be assessed when we consider the behavioral responses of economic agents due to these taxes. This paper shows how income taxation in Brazil gives incentives to some classes of taxpayers to incorporate in order to reduce their tax burden. Microdata analysis on these taxpayers characteristics indicate that the probability of incorporation is strongly related to tax ruleTaxation, Organizational Form, Tax Avoidance.

Intégration culture-élevage dans les Cerrados au Brésil : une solution pour des systèmes durables

Les systèmes actuels de production de grains, viande et lait dans la région des Cerrados présentent des problèmes croissants économiques et de production. Une des solutions pour améliorer la production, tout en maintenant ou en améliorant la qualité des sols, consiste à intégrer dans les mêmes exploitations l'élevage et la production de grains, comme la rotation de cultures annuelles et de prairies, en associant ce processus au renouvellement ou à la récupération des pâturages. Ce travail présente, au travers d'expériences conduites chez les producteurs, les possibilités offertes par cette intégration de cultures à cycles courts et de l'élevage. Ces exemples sont choisis de manière à illustrer la variabilité de sols existante (latossols de diverses textures). (Résumé d'auteur

Hypomethylation of CYP2E1 and DUSP22 Promoters Associated With Disease Activity and Erosive Disease Among Rheumatoid Arthritis Patients.

OBJECTIVE:Epigenetic modifications have previously been associated with rheumatoid arthritis (RA). In this study, we aimed to determine whether differential DNA methylation in peripheral blood cell subpopulations is associated with any of 4 clinical outcomes among RA patients. METHODS:Peripheral blood samples were obtained from 63 patients in the University of California, San Francisco RA cohort (all satisfied the American College of Rheumatology classification criteria; 57 were seropositive for rheumatoid factor and/or anti-cyclic citrullinated protein). Fluorescence-activated cell sorting was used to separate the cells into 4 immune cell subpopulations (CD14+ monocytes, CD19+ B cells, CD4+ naive T cells, and CD4+ memory T cells) per individual, and 229 epigenome-wide DNA methylation profiles were generated using Illumina HumanMethylation450 BeadChips. Differentially methylated positions and regions associated with the Clinical Disease Activity Index score, erosive disease, RA Articular Damage score, Sharp score, medication at time of blood draw, smoking status, and disease duration were identified using robust regression models and empirical Bayes variance estimators. RESULTS:Differential methylation of CpG sites associated with clinical outcomes was observed in all 4 cell types. Hypomethylated regions in the CYP2E1 and DUSP22 gene promoters were associated with active and erosive disease, respectively. Pathway analyses suggested that the biologic mechanisms underlying each clinical outcome are cell type-specific. Evidence of independent effects on DNA methylation from smoking, medication use, and disease duration were also identified. CONCLUSION:Methylation signatures specific to RA clinical outcomes may have utility as biomarkers or predictors of exposure, disease progression, and disease severity