1,237 research outputs found
Pattern languages in HCI: A critical review
This article presents a critical review of patterns and pattern languages in human-computer interaction (HCI). In recent years, patterns and pattern languages have received considerable attention in HCI for their potential as a means for developing and communicating information and knowledge to support good design. This review examines the background to patterns and pattern languages in HCI, and seeks to locate pattern languages in relation to other approaches to interaction design. The review explores four key issues: What is a pattern? What is a pattern language? How are patterns and pattern languages used? and How are values reflected in the pattern-based approach to design? Following on from the review, a future research agenda is proposed for patterns and pattern languages in HCI
Working Group 5: Measurements technology and active experiments
Technology issues identified by working groups 5 are listed. (1) New instruments are needed to upgrade the ability to measure plasma properties in space. (2) Facilities should be developed for conducting a broad range of plasma experiments in space. (3) The ability to predict plasma weather within magnetospheres should be improved and a capability to modify plasma weather developed. (4) Methods of control of plasma spacecraft and spacecraft plasma interference should be upgraded. (5) The space station laboratory facilities should be designed with attention to problems of flexibility to allow for future growth. These issues are discussed
Intrathoracic subclavian artery aneurysm repair in the thoracic endovascular aortic repair era
ObjectiveIntrathoracic subclavian artery aneurysms (SAAs) are rare aneurysms that often occur in association with congenital aortic arch anomalies and/or concomitant thoracic aortic pathology. The advent of thoracic endovascular aortic repair (TEVAR) methods may complement or replace conventional open SAA repair. Herein, we describe our experience with SAA repair in the TEVAR era.MethodsA retrospective review was performed of all intrathoracic SAAs repaired at a single institution since United States Food and Drug Administration approval of TEVAR in 2005.ResultsNineteen patients underwent 20 operations to repair 22 (13 native, nine aberrant) SAAs with an intrathoracic component. Mean SAA diameter was 3.1 cm (range, 1.6-6.0 cm). Mean patient age was 57 years (range, 24-80 years). Twenty-one percent (n = 4) of patients had a connective tissue disorder (two Loeys-Dietz, two Marfan). Thirty-six percent (n = 8) of SAAs were repaired by open techniques and 64% (n = 14) via a TEVAR-based approach. All TEVAR cases required proximal landing zone in the aortic arch (zone 0-2), and revascularization of at least one arch vessel was required in 83% (10/12) of patients. Concomitant repair of associated aortic pathology was performed in 50% (n = 10) of operations. Thirty-day/in-hospital rates of death, stroke, and permanent paraplegia/paraparesis were 5% (n = 1), 5% (n = 1), and 0%, respectively. Over mean (standard deviation) follow-up of 24 (21) months, 16% (n = 3) of patients required reintervention for subclavian artery bypass graft revision (n = 2) or type II endoleak (n = 1).ConclusionsThis is the largest single-institution series to date of TEVAR for SAA repair. Modern endovascular techniques expand SAA repair options with excellent results. The majority of SAAs and nearly all aberrant SAAs (Kommerell's diverticulum) can now be repaired using a TEVAR-based approach without the need for sternotomy or thoracotomy
The Effect of Poverty Levels and Minority Percentages on Lead Content in South Carolina Midlands School Drinking Water
Religious Commitment and Meaning in Life
The purpose of this study was to investigate the relationship between meaning or purpose in life as measured by Crumbaugh\u27s Purpose in Life Test, and the degree of religious commitment of college students, with particular interest in the members of the Church of Jesus Christ of Latter-day Saints (LDS). Religious commitment was measured by Hoge\u27s Intrinsic Religious Motivation Scale (IRM).
Two hundred and fifty-five undergraduates, 122 males and 132 females, enrolled in introductory psychology and sociology classes at Utah State University during spring quarter, 1975, served as subjects.
A two-way analysis of variance calculated separately for the LDS and non-LDS groups was used to test three hypotheses: (1) there will be a significant difference among the mean PIL scores for the high, moderate, and low religious commitment groups (in that order); (2) females will be significantly higher in their sense of purpose in life than males; (3) females will be significantly higher in their sense of purpose in life in all religious commitment groups.
Hypothesis 1 was significant beyond the .05 level for the LDS group. A Sheffe test indicated the difference was between the high and the low religious commitment groups only. Hypotheses 2 and 3 were not supported. None of the three hypotheses were supported for the nonLDS group. T-ratios computed between the three corresponding levels of religious commitment for the LDS and non-LDS groups were significant beyond the .05 level.
A significant positive relationship for males beyond the .05 level was found between sex and religious commitment. No relationship was found between sex and purpose in life. A significant positive relationship beyond the .05 level was found between religious commitment and purpose in life. No significant differences were found between year in school, marital status, and socioeconomic status on either purpose in life or religious commitment. Significant differences beyond the .05 level were found between religious commitment and church attendance, and between religious commitment and activity in church organizations.
It was concluded that the results support the premise that religion can have a significant impact on an individual\u27s sense of purpose in life as defined by Frankl (1963), particularly if the individual\u27s religion encourages active involvement on the part of the individual. The effect is especially strong if high religious belief, high religious participation, and social activity outside of church occur together
Sonically-enhanced widgets: comments on Brewster and Clarke, ICAD 1997
This paper presents a review of the research surrounding the paper “The Design and Evaluation of a Sonically Enhanced Tool Palette” by Brewster and Clarke from ICAD 1997. A historical perspective is given followed by a discussion of how this work has fed into current developments in the area
Intruder bands and configuration mixing in the lead isotopes
A three-configuration mixing calculation is performed in the context of the
interacting boson model with the aim to describe recently observed collective
bands built on low-lying states in neutron-deficient lead isotopes. The
configurations that are included correspond to the regular, spherical states as
well as two-particle two-hole and four-particle four-hole excitations across
the Z=82 shell gap.Comment: 20 pages, 4 figures, accepted by PRC, reference added for section 1
in this revised versio
Differences in smoking associated DNA methylation patterns in South Asians and Europeans
This is a freely-available open access publication. Please cite the published version which is available via the DOI link in this record.Background
DNA methylation is strongly associated with smoking status at multiple sites across the genome. Studies have largely been restricted to European origin individuals yet the greatest increase in smoking is occurring in low income countries, such as the Indian subcontinent. We determined whether there are differences between South Asians and Europeans in smoking related loci, and if a smoking score, combining all smoking related DNA methylation scores, could differentiate smokers from non-smokers.
Results
Illumina HM450k BeadChip arrays were performed on 192 samples from the Southall And Brent REvisited (SABRE) cohort. Differential methylation in smokers was identified in 29 individual CpG sites at 18 unique loci. Interaction between smoking status and ethnic group was identified at the AHRR locus. Ethnic differences in DNA methylation were identified in non-smokers at two further loci, 6p21.33 and GNG12. With the exception of GFI1 and MYO1G these differences were largely unaffected by adjustment for cell composition. A smoking score based on methylation profile was constructed. Current smokers were identified with 100% sensitivity and 97% specificity in Europeans and with 80% sensitivity and 95% specificity in South Asians.
Conclusions
Differences in ethnic groups were identified in both single CpG sites and combined smoking score. The smoking score is a valuable tool for identification of true current smoking behaviour. Explanations for ethnic differences in DNA methylation in association with smoking may provide valuable clues to disease pathways.Wellcome Trust Enhancement grantMedical Research CouncilDiabetes UKthe British Heart Foundatio
The matriarchal society in Flannery O\u27Connor\u27s fiction: its characteristics, treatment, and purpose
EnglishMaster of Arts (M.A.
- …
