1,312 research outputs found

    Checklist of British and Irish Hymenoptera - Ceraphronoidea

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    This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. The attached file is the published version of the article.NHM Repositor

    Checklist of British and Irish Hymenoptera - Chalcidoidea and Mymarommatoidea

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    This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. The attached file is the published version of the article.NHM Repositor

    A Discrete Version of the Inverse Scattering Problem and the J-matrix Method

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    The problem of the Hamiltonian matrix in the oscillator and Laguerre basis construction from the S-matrix is treated in the context of the algebraic analogue of the Marchenko method.Comment: 11 pages. The Laguerre basis case is adde

    Techno-economic demand projections and scenarios for the Bolivian energy system

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    Increasing energy access in emerging economies has played an important role to maintain or achieve desirable social and economic development targets. As a consequence, the growing energy requirements need policy instruments to ensure energy supply for future generations. The literature reports many studies with different approaches to model and test policy measures in the energy sector, however few energy-related studies for Bolivia are available. This paper addresses this knowledge gap, representing the first national level energy demand model and projections for Bolivia. The model use demographic, economic, technology and policy trends with a pragmatic model structure that combines bottom-up and top-down modelling. The scenario analysis has a particular focus on alternatives for energy savings, energy mix diversification and air quality. Three scenarios were analysed: Energy Savings, Fuel Substitution and the aggregate effects in a Combined scenario. The reference scenario results show the overall energy consumption grows 134% in 2035 compared to 2012 with an annual average growth of 3.8%. The final energy demand in the energy savings scenario is 8.5% lower than the Reference scenario, 1.5% lower in the fuel substitution scenario and 9.4% lower in the combined Scenario. The aggregate impact of both energy savings and fuel substitution measures leads to potential avoided emissions of 25.84 million Tons of CO2 equivalent in the model horizon 2012-2035

    Ultramicronized palmitoylethanolamide rescues learning and memory impairments in a triple transgenic mouse model of Alzheimer's disease by exerting anti-inflammatory and neuroprotective effects

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    In an aging society, Alzheimer’s disease (AD) exerts an increasingly serious health and economic burden. Current treatments provide inadequate symptomatic relief as several distinct pathological processes are thought to underlie the decline of cognitive and neural function seen in AD. This suggests that the efficacy of treatment requires a multitargeted approach. In this context, palmitoylethanolamide (PEA) provides a novel potential adjunct therapy that can be incorporated into a multitargeted treatment strategy. We used young (6-month-old) and adult (12-month-old) 3×Tg-AD mice that received ultramicronized PEA (um-PEA) for 3 months via a subcutaneous delivery system. Mice were tested with a range of cognitive and noncognitive tasks, scanned with magnetic resonance imaging/magnetic resonance spectroscopy (MRI/MRS), and neurochemical release was assessed by microdialysis. Potential neuropathological mechanisms were assessed postmortem by western blot, reverse transcription–polymerase chain reaction (RT-PCR), and immunofluorescence. Our data demonstrate that um-PEA improves learning and memory, and ameliorates both the depressive and anhedonia-like phenotype of 3×Tg-AD mice. Moreover, it reduces Aβ formation, the phosphorylation of tau proteins, and promotes neuronal survival in the CA1 subregion of the hippocampus. Finally, um-PEA normalizes astrocytic function, rebalances glutamatergic transmission, and restrains neuroinflammation. The efficacy of um-PEA is particularly potent in younger mice, suggesting its potential as an early treatment. These data demonstrate that um-PEA is a novel and effective promising treatment for AD with the potential to be integrated into a multitargeted treatment strategy in combination with other drugs. Um-PEA is already registered for human use. This, in combination with our data, suggests the potential to rapidly proceed to clinical use

    Agent-based Social Psychology: from Neurocognitive Processes to Social Data

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    Moral Foundation Theory states that groups of different observers may rely on partially dissimilar sets of moral foundations, thereby reaching different moral valuations. The use of functional imaging techniques has revealed a spectrum of cognitive styles with respect to the differential handling of novel or corroborating information that is correlated to political affiliation. Here we characterize the collective behavior of an agent-based model whose inter individual interactions due to information exchange in the form of opinions are in qualitative agreement with experimental neuroscience data. The main conclusion derived connects the existence of diversity in the cognitive strategies and statistics of the sets of moral foundations and suggests that this connection arises from interactions between agents. Thus a simple interacting agent model, whose interactions are in accord with empirical data on conformity and learning processes, presents statistical signatures consistent with moral judgment patterns of conservatives and liberals as obtained by survey studies of social psychology.Comment: 11 pages, 4 figures, 2 C codes, to appear in Advances in Complex System

    (UN)LEARNING SOCIAL CHANGE STORYTELLING

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    In this essay, I discuss a teaching activity I created which embraces the dynamic of learning/unlearning to foster a complex understanding of social change storytelling

    Making a home, finding a job: investigating early housing and employment outcomes for young people leaving care

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    This paper presents findings from a new study of outcomes for young people leaving care funded by the Department for Education and Skills. It reports findings for a sample of 106 young people in relation to progress made in housing and employment some 12-15 months after leaving care. The generally poor employment outcomes of care leavers are acknowledged, but ingredients that make for success are also highlighted, including the value of settled care and post-care careers, sound career planning and, significantly, the value of delaying young people's transitions from care. Early career paths also interconnect with how young people fare in housing, in developing life skills and with other problems in their lives after leaving care. Housing outcomes were more encouraging and predominantly shaped by events after leaving care, and faring well in housing was the factor most closely associated with positive mental well-being in young people. Some groups that are at risk of faring badly are identified, including young people with mental-health problems, young people with persistent offending or substance misuse problems and, in some respects, young disabled people. The implications of these findings for leaving care services are considered
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