Magnetized black holes and black rings in the higher dimensional dilaton gravity

In this paper we consider magnetized black holes and black rings in the higher dimensional dilaton gravity. Our study is based on exact solutions generated by applying a Harrison transformation to known asymptotically flat black hole and black ring solutions in higher dimensional spacetimes. The explicit solutions include the magnetized version of the higher dimensional Schwarzschild-Tangherlini black holes, Myers-Perry black holes and five dimensional (dipole) black rings. The basic physical quantities of the magnetized objects are calculated. We also discuss some properties of the solutions and their thermodynamics. The ultrarelativistic limits of the magnetized solutions are briefly discussed and an explicit example is given for the $D$-dimensional magnetized Schwarzschild-Tangherlini black holes.Comment: LaTeX, 23 pages; v2 references and comments added, some typos corrected;v3 minor change

Modeling Star counts in the Monoceros stream and the Galactic anti-centre

There is a continued debate as to the form of the outer disc of the Milky Way galaxy, which has important implications for its formation. Stars are known to exist at a galacto-centric distance of at least 20 kpc. However, there is much debate as to whether these stars can be explained as being part of the disc or whether another extra galactic structure, the so called Monoceros ring/stream, is required. To examine the outer disc of the Galaxy toward the anti-centre to determine whether the star counts can be explained by the thin and thick discs alone. Using Sloan star counts and extracting the late F and early G dwarfs it is possible to directly determine the density of stars out to a galacto-centric distance of about 25 kpc. These are then compared with a simple flared disc model. A flared disc model is shown to reproduce the counts along the line of sights examined, if the thick disc does not have a sharp cut off. The flare starts at a Galacto-centric radius of 16 kpc and has a scale length of 4.5+/-1.5 kpc. Whilst the interpretation of the counts in terms of a ring/stream cannot be definitely discounted, it does not appear to be necessary, at least along the lines of sight examined towards the anti centre.Comment: 11 pages, 4 figures, accepted to be published in A&

A study to explore the use of orbital remote sensing to determine native arid plant distribution

The author has identified the following significant results. It is possible to determine, from ERTS imagery, native arid plant distribution. Using techniques of multispectral masking and extensive fieldwork, three native vegetation communities were defined and mapped in the Avra Valley study area. A map was made of the Yuma area with the aid of ground truth correlations between areas of desert pavement visible on ERTS images and unique vegetation types. With the exception of the Yuma soil-vegetation correlation phenomena, only very gross differentiations of desert vegetation communities can be made from ERTS data. Vegetation communities with obvious vegetation density differences such as saguaro-paloverde, creosote bush, and riparian vegetation can be separated on the Avra Valley imagery while more similar communities such as creosote bush and saltbush could not be differentiated. It is suggested that large differences in vegetation density are needed before the signatures of two different vegetation types can be differentiated on ERTS imagery. This is due to the relatively insignificant contribution of vegetation to the total radiometric signature of a given desert scene. Where more detailed information concerning the vegetation of arid regions is required, large scale imagery is appropriate

An Exploratory Study of Suboxone (Buprenorphine/ Naloxone) Film Splitting: Cutting Methods, Content Uniformity, and Stability

Suboxone films are U.S. Food and Drug Administration approved to treat opioid dependence. While the package insert states that films should not be cut, physicians often prescribe film fractions for treatment and tapering. There is no data to support this practice, and this study was initiated to evaluate cutting methods, content uniformity, and stability of split films. Suboxone 8-mg buprenorphine/2-mg naloxone films were split using four methods: 1) ruler/razor cut, 2) scissor cut, 3) fold/rip, and 4) fold/scissor cut. United States Pharmacopeia Chapter \u3c905\u3e was used to evaluate the weight variation and content uniformity of split films. The stability of split films stored in polybags was evaluated over 7 days. A stability-indicating high-performance liquid chromatography method was used for content uniformity and stability evaluation. The weight variation results were acceptable for the half films from all four cutting methods, but this was not true for the quarter films. The method of ruler/razor cut was determined most favorable and used for the content uniformity test. Based on the high-performance liquid chromatography results, the half films from the ruler/razor cut method met the passing criteria of United States Pharmacopeia Chapter \u3c905\u3e with acceptance values of 9.8 to 10.4 for buprenorphine and 8.4 to 11.5 for naloxone (≤15 is considered passing). The stability results indicated that both actives retained \u3e97.7% of initial strength. Four cutting methods were found to be acceptable for splitting Suboxone films into half but not quarter fractions. The half films from the ruler/razor cut method also passed United States Pharmacopeia Chapter \u3c905\u3e content uniformity test. Both actives remained stable for 7 days when the half films were stored in polybags at room temperature

The Impact on U.K. Acquirers of Domestic, Cross-border, Public and Private Acquisitions

We examine the announcement and post-acquisition share returns of 4,000 acquisitions by U.K. public firms during 1984-1998. We include acquisitions of domestic and cross-border targets, and of both publicly quoted and privately held targets. In acquisitions of domestic public targets, abnormal returns are negative over both the announcement and post-acquisition period. In acquisitions of cross-border public targets, abnormal returns are zero over the announcement period but negative over the post-acquisition period. In contrast, acquisitions of both domestic and cross-border private targets result in positive announcement returns and zero long run returns. The main difference between private and public acquisitions is that glamour acquirers experience negative announcement and long run returns in public acquisitions, whereas glamour acquirers do not under-perform in private acquisitions. Furthermore, whereas the under-performance of domestic public acquisitions is limited to acquirers using non-cash methods of payment, acquirers of domestic private targets that use non-cash methods do not under-perform. Overall, cross-border acquisitions result in lower announcement and long run returns than domestic acquisitions. In cross-border acquisitions involving high?tech firms both announcement and long run returns are positive, whilst non-high-tech cross-border acquisitions experience zero announcement returns followed by negative long run performance. Our results also suggest that, in cross-border acquisitions, the national cultural difference between the bidder and target countries has a significantly negative impact on long run returns. This paper replaces WP214.Mergers and acquisitions; acquirer share returns; Cross-border targets; private targets

The SUMO Ligase Protein Inhibitor of Activated STAT 1 (PIAS1) is a constituent PML-NB protein that contributes to the intrinsic antiviral immune response to herpes simplex virus 1 (HSV-1)

Aspects of intrinsic antiviral immunity are mediated by promyelocytic leukaemia (PML)-nuclear body (PML-NB) constituent proteins. During herpesvirus infection, these antiviral proteins are independently recruited to nuclear domains that contain infecting viral genomes to cooperatively promote viral genome silencing. Central to the execution of this particular antiviral response is the small ubiquitin-like modifier (SUMO) signalling pathway. However, the participating SUMOylation enzymes are not fully characterized. We identify the SUMO ligase Protein Inhibitor of Activated STAT1 (PIAS1) as a constituent PML-NB protein. We show that PIAS1 localizes at PML-NBs in a SUMO interaction motif (SIM)-dependent manner that requires SUMOylated or SUMOylation competent PML. Following infection with herpes simplex virus 1 (HSV-1), PIAS1 is recruited to nuclear sites associated with viral genome entry in a SIM-dependent manner, consistent with the SIM-dependent recruitment mechanisms of other well characterized PML-NB proteins. In contrast to Daxx and Sp100, however, the recruitment of PIAS1 is enhanced by PML. PIAS1 promotes the stable accumulation of SUMO1 at nuclear sites associated with HSV-1 genome entry, whereas the accumulation of other evaluated PML-NB proteins occurs independently of PIAS1. We show that PIAS1 cooperatively contributes to HSV-1 restriction through mechanisms that are additive to those of PML and cooperative with those of PIAS4. The antiviral mechanisms of PIAS1 are counteracted by ICP0, the HSV-1 SUMO-targeted ubiquitin ligase, which disrupts the recruitment of PIAS1 to nuclear domains that contain infecting HSV-1 genomes through mechanisms that do not directly result in PIAS1 degradation

AAOmega spectroscopy of 29 351 stars in fields centered on ten Galactic globular clusters

Galactic globular clusters have been pivotal in our understanding of many astrophysical phenomena. Here we publish the extracted stellar parameters from a recent large spectroscopic survey of ten globular clusters. A brief review of the project is also presented. Stellar parameters have been extracted from individual stellar spectra using both a modified version of the Radial Velocity Experiment (RAVE) pipeline and a pipeline based on the parameter estimation method of RAVE. We publish here all parameters extracted from both pipelines. We calibrate the metallicity and convert this to [Fe/H] for each star and, furthermore, we compare the velocities and velocity dispersions of the Galactic stars in each field to the Besan\c{c}on Galaxy model. We find that the model does not correspond well with the data, indicating that the model is probably of little use for comparisons with pencil beam survey data such as this.Comment: 6 pages, 5 figures, 4 tables. Accepted for publication in A&A. Data described in tables will be available on CDS (at http://cdsweb.u-strasbg.fr/cgi-bin/qcat?J/A+A/530/A31) once publishe

Medication adherence in patients with myotonic dystrophy and facioscapulohumeral muscular dystrophy

Myotonic dystrophy (DM) and facioscapulohumeral muscular dystrophy (FSHD) are the two most common adult muscular dystrophies and have progressive and often disabling manifestations. Higher levels of medication adherence lead to better health outcomes, especially important to patients with DM and FSHD because of their multisystem manifestations and complexity of care. However, medication adherence has not previously been studied in a large cohort of DM type 1 (DM1), DM type 2 (DM2), and FSHD patients. The purpose of our study was to survey medication adherence and disease manifestations in patients enrolled in the NIH-supported National DM and FSHD Registry. The study was completed by 110 DM1, 49 DM2, and 193 FSHD patients. Notable comorbidities were hypertension in FSHD (44 %) and DM2 (37 %), gastroesophageal reflux disease in DM1 (24 %) and DM2 (31 %) and arrhythmias (29 %) and thyroid disease (20 %) in DM1. Each group reported high levels of adherence based on regimen complexity, medication costs, health literacy, side effect profile, and their beliefs about treatment. Only dysphagia in DM1 was reported to significantly impact medication adherence. Approximately 35 % of study patients reported polypharmacy (taking 6 or more medications). Of the patients with polypharmacy, the DM1 cohort was significantly younger (mean 55.0 years) compared to DM2 (59.0 years) and FSHD (63.2 years), and had shorter disease duration (mean 26 years) compared to FSHD (26.8 years) and DM2 (34.8 years). Future research is needed to assess techniques to ease pill swallowing in DM1 and to monitor polypharmacy and potential drug interactions in DM and FSHD