Experimental Test of the Dynamical Coulomb Blockade Theory for Short Coherent Conductors

We observed the recently predicted quantum suppression of dynamical Coulomb blockade on short coherent conductors by measuring the conductance of a quantum point contact embedded in a tunable on-chip circuit. Taking advantage of the circuit modularity we measured most parameters used by the theory. This allowed us to perform a reliable and quantitative experimental test of the theory. Dynamical Coulomb blockade corrections, probed up to the second conductance plateau of the quantum point contact, are found to be accurately normalized by the same Fano factor as quantum shot noise, in excellent agreement with the theoretical predictions.Comment: 4 pages, 4 figures, accepted for publication in Physical Review Letter

Dynamical Coulomb blockade of multiple Andreev reflections

We analyze the dynamical Coulomb blockade of multiple Andreev reflections (MAR) in a superconducting quantum point contact coupled to a macroscopic impedance. We find that at very low transmission the blockade scales as $n^2$ with $n = {Int}(2\Delta/eV)$, where $V$ is the bias voltage and $\Delta$ is the superconducting gap, as it would correspond to the occurrence of "shots" of charge $ne$. For higher transmission the blockade is reduced both due to Pauli principle and to elastic renormalization of the MAR probability, and for certain voltage regions it may even become an "antiblockade", i.e. the current is enhanced due to the coupling with the electromagnetic environment.Comment: 5 pages, 4 figures, submitted to Phys. Rev. Let

A one-channel conductor in an ohmic environment: mapping to a TLL and full counting statistics

It is shown that a one-channel mesoscopic conductor in an ohmic environment can be mapped to the problem of a backscattering impurity in a Tomonaga-Luttinger liquid (TLL). This allows to determine non perturbatively the effect of the environment on $I-V$ curves, and to find an exact relationship between dynamic Coulomb blockade and shot noise. We investigate critically how this relationship compares to recent proposals in the literature. The full counting statistics is determined at zero temperature.Comment: 5 pages, 2 figures, shortened version for publication in Phys. Rev. Let

Inelastic Interaction Corrections and Universal Relations for Full Counting Statistics

We analyze in detail the interaction correction to Full Counting Statistics (FCS) of electron transfer in a quantum contact originating from the electromagnetic environment surrounding the contact. The correction can be presented as a sum of two terms, corresponding to elastic/inelastic electron transfer. Here we primarily focus on the inelastic correction. For our analysis, it is important to understand more general -- universal -- relations imposed on FCS only by quantum mechanics and statistics with no regard for a concrete realization of a contact. So we derive and analyze these relations. We reveal that for FCS the universal relations can be presented in a form of detailed balance. We also present several useful formulas for the cumulants. To facilitate the experimental observation of the effect, we evaluate cumulants of FCS at finite voltage and temperature. Several analytical results obtained are supplemented by numerical calculations for the first three cumulants at various transmission eigenvalues.Comment: 10 pages, 3 figure

Superconducting Quantum Point Contacts

We review our experiments on the electronic transport properties of atomic contacts between metallic electrodes, in particular superconducting ones. Despite ignorance of the exact atomic configuration, these ultimate quantum point contacts can be manipulated and well characterized in-situ. They allow performing fundamental tests of the scattering theory of quantum transport. In particular, we discuss the case of the Josephson effect

Analytic morphomics identifies predictors of new‐onset diabetes after liver transplantation

Among liver transplant recipients, development of post‐transplant complications such as new‐onset diabetes after transplantation (NODAT) is common and highly morbid. Current methods of predicting patient risk are inaccurate in the pre‐transplant period, making implementation of targeted therapies difficult. We sought to determine whether analytic morphomics (using computed tomography scans) could be used to predict the incidence of NODAT. We analyzed peri‐transplant scans from 216 patients with varying indications for liver transplantation, among whom 61 (28%) developed NODAT. Combinations of visceral fat, subcutaneous fat, and psoas area were considered in addition to traditional risk factors. On multivariate analysis adjusting for usual risk factors such as type of immunosuppression, subcutaneous fat thickness remained significantly associated with NODAT (OR = 1.43, 95% CI 1.00–1.88, p = 0.047). Subgroup analysis showed that patients with later‐onset of NODAT had higher visceral fat, whereas subcutaneous fat thickness was more correlated with earlier‐onset of NODAT (using 10 months post‐transplant as the cut‐off).ConclusionAnalytic morphomics may be used to help assess NODAT risk in patients undergoing liver transplantation.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/111210/1/ctr12537.pd

Subharmonic Shapiro steps and assisted tunneling in superconducting point contacts

We analyze the current in a superconducting point contact of arbitrary transmission in the presence of a microwave radiation. The interplay between the ac Josephson current and the microwave signal gives rise to Shapiro steps at voltages V = (m/n) \hbar \omega_r/2e, where n,m are integer numbers and \omega_r is the radiation frequency. The subharmonic steps (n different from 1) are a consequence of the ocurrence of multiple Andreev reflections (MAR) and provide an unambiguous signature of the peculiar ac Josephson effect at high transmission. Moreover, the dc current exhibits a rich subgap structure due to photon-assisted MARs.Comment: Revtex, 4 pages, 4 figure

Direct link between Coulomb blockade and shot noise in a quantum coherent structure

We analyze the current-voltage characteristic of a quantum conduction channel coupled to an electromagnetic environment of arbitrary frequency-dependent impedance. In the weak blockade regime the correction to the ohmic behavior is directly related to the channel current fluctuations vanishing at perfect transmission in the same way as shot noise. This relation can be generalized to describe the environmental Coulomb blockade in a generic mesoscopic conductor coupled to an external impedance, as the response of the latter to the current fluctuations in the former.Comment: 12 pages, 2 figures, submitted to Phys. Rev. Let

The number of transmission channels through a single-molecule junction

We calculate transmission eigenvalue distributions for Pt-benzene-Pt and Pt-butadiene-Pt junctions using realistic state-of-the-art many-body techniques. An effective field theory of interacting $\pi$-electrons is used to include screening and van der Waals interactions with the metal electrodes. We find that the number of dominant transmission channels in a molecular junction is equal to the degeneracy of the molecular orbital closest to the metal Fermi level.Comment: 9 pages, 8 figure

Cancer risk in childhood-onset systemic lupus

INTRODUCTION: The aim of this study was to assess cancer incidence in childhood-onset systemic lupus erythematosus (SLE). METHODS: We ascertained cancers within SLE registries at 10 pediatric centers. Subjects were linked to cancer registries for the observational interval, spanning 1974 to 2009. The ratio of observed to expected cancers represents the standardized incidence ratio (SIR) or relative cancer risk in childhood-onset SLE, versus the general population. RESULTS: There were 1020 patients aged <18 at cohort entry. Most (82%) were female and Caucasian; mean age at cohort entry was 12.6 years (standard deviation (SD) = 3.6). Subjects were observed for a total of 7,986 (average 7.8) patient-years. Within this interval, only three invasive cancers were expected. However, 14 invasive cancers occurred with an SIR of 4.7, 95% confidence interval (CI) 2.6 to 7.8. Three hematologic cancers were found (two non-Hodgkin’s lymphoma, one leukemia), for an SIR of 5.2 (95% CI 1.1 to 15.2). The SIRs stratified by age group and sex, were similar across these strata. There was a trend for highest cancer occurrence 10 to 19 years after SLE diagnosis. CONCLUSIONS: These results suggest an increased cancer risk in pediatric onset SLE versus the general population. In absolute terms, this represents relatively few events. Of note, risk may be highest only after patients have transferred to adult care