2,557 research outputs found
Micromagnetic simulations of the magnetization precession induced by a spin polarized current in a point contact geometry
This paper is devoted to numerical simulations of the magnetization dynamics
driven by a spin-polarized current in extended ferromagnetic multilayers when a
point-contact setup is used. We present (i) detailed analysis of methodological
problems arising by such simulations and (ii) physical results obtained on a
system similar to that studied in Rippard et al., Phys. Rev. Lett., v. 92,
027201 (2004). We demonstrate that the usage of a standard Slonczewski
formalism for the phenomenological treatment of a spin-induced torque leads to
a qualitative disagreement between simulation results and experimental
observations and discuss possible reasons for this discrepancy.Comment: Invited paper on MMM2005 (San Jose); accepted for publication in J.
Applied Physic
"Ultimate state" of two-dimensional Rayleigh-Benard convection between free-slip fixed temperature boundaries
Rigorous upper limits on the vertical heat transport in two dimensional
Rayleigh-Benard convection between stress-free isothermal boundaries are
derived from the Boussinesq approximation of the Navier-Stokes equations. The
Nusselt number Nu is bounded in terms of the Rayleigh number Ra according to
uniformly in the Prandtl number Pr. This Nusselt
number scaling challenges some theoretical arguments regarding the asymptotic
high Rayleigh number heat transport by turbulent convection.Comment: 4 page
Variational bounds on the energy dissipation rate in body-forced shear flow
A new variational problem for upper bounds on the rate of energy dissipation
in body-forced shear flows is formulated by including a balance parameter in
the derivation from the Navier-Stokes equations. The resulting min-max problem
is investigated computationally, producing new estimates that quantitatively
improve previously obtained rigorous bounds. The results are compared with data
from direct numerical simulations.Comment: 15 pages, 7 figure
Near-Infrared Photometric Survey of Herbig Ae/Be Candidate Stars
We report near-infrared photometric measurements of 35 Herbig Ae/Be candidate
stars obtained with direct imaging and aperture photometry. Observations were
made through the broadband J, H, and K' filters, with each source imaged in at
least one of the wavebands. We achieved subarcsecond angular resolution for all
observations, providing us with the opportunity to search for close binary
candidates and extended structure. The imaging revealed five newly identified
binary candidates and one previously resolved T Tauri binary among the target
sources with separations of <~2.5". Separate photometry is provided for each of
the binary candidate stars. We detect one extended source that has been
identified as a protoplanetary nebula. Comparing our magnitudes to past
measurements yields significant differences for some sources, possibly
indicating photometric variability. H-band finding charts for all of our
sources are provided to aid follow-up high-resolution imaging.Comment: 22 pages, 1 figure, accepted for publication in A
RNA interference screening reveals host CaMK4 as a regulator of cryptococcal uptake and pathogenesis
ABSTRACT
Cryptococcus neoformans
, the causative agent of cryptococcosis, is an opportunistic fungal pathogen that kills over 200,000 individuals annually. This yeast may grow freely in body fluids, but it also flourishes within host cells. Despite extensive research on cryptococcal pathogenesis, host genes involved in the initial engulfment of fungi and subsequent stages of infection are woefully understudied. To address this issue, we combined short interfering RNA silencing and a high-throughput imaging assay to identify host regulators that specifically influence cryptococcal uptake. Of 868 phosphatase and kinase genes assayed, we discovered 79 whose silencing significantly affected cryptococcal engulfment. For 25 of these, the effects were fungus specific, as opposed to general alterations in phagocytosis. Four members of this group significantly and specifically altered cryptococcal uptake; one of them encoded CaMK4, a calcium/calmodulin-dependent protein kinase. Pharmacological inhibition of CaMK4 recapitulated the observed defects in phagocytosis. Furthermore, mice deficient in CaMK4 showed increased survival compared to wild-type mice upon infection with
C. neoformans
. This increase in survival correlated with decreased expression of pattern recognition receptors on host phagocytes known to recognize
C. neoformans
. Altogether, we have identified a kinase that is involved in
C. neoformans
internalization by host cells and in host resistance to this deadly infection.
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5-fluorocytosine resistance is associated with hypermutation and alterations in capsule biosynthesis in Cryptococcus
The Evolution of the Rationale for Government Involvement in Agriculture
Agricultural and Food Policy, Q18, Q10,
Variational bound on energy dissipation in turbulent shear flow
We present numerical solutions to the extended Doering-Constantin variational
principle for upper bounds on the energy dissipation rate in plane Couette
flow, bridging the entire range from low to asymptotically high Reynolds
numbers. Our variational bound exhibits structure, namely a pronounced minimum
at intermediate Reynolds numbers, and recovers the Busse bound in the
asymptotic regime. The most notable feature is a bifurcation of the minimizing
wavenumbers, giving rise to simple scaling of the optimized variational
parameters, and of the upper bound, with the Reynolds number.Comment: 4 pages, RevTeX, 5 postscript figures are available as one .tar.gz
file from [email protected]
Subdiffusion-limited reactions
We consider the coagulation dynamics A+A -> A and A+A A and the
annihilation dynamics A+A -> 0 for particles moving subdiffusively in one
dimension. This scenario combines the "anomalous kinetics" and "anomalous
diffusion" problems, each of which leads to interesting dynamics separately and
to even more interesting dynamics in combination. Our analysis is based on the
fractional diffusion equation
Diffusion-Limited Aggregation Processes with 3-Particle Elementary Reactions
A diffusion-limited aggregation process, in which clusters coalesce by means
of 3-particle reaction, A+A+A->A, is investigated. In one dimension we give a
heuristic argument that predicts logarithmic corrections to the mean-field
asymptotic behavior for the concentration of clusters of mass at time ,
, for . The total
concentration of clusters, , decays as at . We also investigate the problem with a localized steady source of
monomers and find that the steady-state concentration scales as
, , and , respectively,
for the spatial dimension equal to 1, 2, and 3. The total number of
clusters, , grows with time as , , and
for = 1, 2, and 3. Furthermore, in three dimensions we
obtain an asymptotic solution for the steady state cluster-mass distribution:
, with the scaling function
and the scaling variable .Comment: 12 pages, plain Te
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