Immunologic aspects of acute viral hepatitis B in children

Last year (2007) the tendency of the growth of morbidity by acute viral hepatites persists. Morbidity in Ukraine is in 5-20 times higher in the USA and in the countries of the Western Europe. The prognosis and clinical course of a HBV-infection, were due to the state of immune system, the degree of infection and the virus virulence. According to statistics for each third inhabitant of Ukraine there are a secondary immunodeficiency. Its development is influenced by radiation pollution (Chernobyl), psychoemotional stresses, inadequate treatment, an irrational feed

Investigations of the antimicrobial activity of aminomethanesulfonic acids against strains of Staphylococcus aureus with different antimicrobial susceptibility

One of the tasks of the WHO strategy against development of antibiotic resistance in microorganisms is the searching for new compounds with antimicrobial activity to develop new antimicrobial medicines. The aim of this study was to determine the inhibitory effect of aminosulfonic acid (AMSA) and its new derivatives such as N-methyl-(MeAMSA), N-(2-hydroxyethyl)-(HEAMSA), N-benzyl-(BnAMSA), N-(tert-butyl)-(t-BuAMSA), 4-(N-phenylaminomethyl)phenyl (PhAMPhAMSA) on the growth of Staphylococcus aureus strains with different antimicrobial susceptibility. Materials and methods. The method of serial dilution was used in the study. The chemical compounds were dissolved in DMSO (a final concentration of 1%). Then dilutions of the compounds were performed using liquid Mueller-Hinton medium to final concentrations of 5 mM and 10 m×M. The results were assessed using a Densi-La-Meter after 18-20 hours of incubation at 37 °C. Sulfanilamide was used as a reference preparation. Results. AMSA suppressed the growth of all tested strains regardless of their antibiotic resistance profiles even more than sulfanilamide. MeAMSA inhibited the growth of S. aureus ATCC 25923 and S. aureus 2781 strains more than the reference preparation, but less than AMSA. No inhibitory effect was observed on the antibiotic resistant S. aureus Kunda strain. Compounds of HEAMSA, t-BuAMSA, BnAMSA stably inhibited the growth of all strains tested. These compounds suppressed the growth of S. aureus ATCC 25923 and S. aureus Kunda strains more than sulfanilamide. However, the reference preparation exhibited greater S. aureus 2781 growth inhibition than investigated preparations. Compound PhAMPhAMSA did not show antimicrobial activity. Conclusions. Aminomethanesulfonic acid derivatives suppressed the growth of Staphylococcus aureus strains with different antimicrobial susceptibility and their antimicrobial activity was higher than that of sulfanilamide. Further study of these compounds efficacy on different types of microorganisms can be considered promising for the development of new antimicrobial agents. It would also be appropriate to study the combined use of these substances with antibiotics

Prospects of the Improvement of Operations of District Police Inspectors in the Republic of Belarus

The article examines the approaches available in foreign practice to improve the organization of the activities of district police inspectors. The article analyzes the practice of conducting an experiment in the Republic of Belarus on the creation of a precinct police commissioner, who is simultaneously endowed with the competence of a precinct police inspector, a precinct inspector of the juvenile affairs inspectorate and a criminal investigation officer. The problematic issues that prevented the maximum achievement of the set goals of the experiment are highlighted. On the basis of the conducted empirical research, the prospects for further effective functioning of the new form of work of district police inspectors are determined.</jats:p

Proteolysis Inhibitor E-Aminocaproic Acid as Effective Drug for Prevention and Treatment of Influenza, Other Acute Respiratory Viral Infections and their Bacterial Complications

We have established the efficacy of proteolysis inhibitor (PI) aminocaproic acid (ACA) in viral infections as a result of its impact on the etiological factor and pathogenesis of the infection. The Ministry of Health of Ukraine on the basis of our studies and clinical trials allowed using ACA for prophylaxis and treatment of influenza and other acute respiratory viral infections (ARVI). Including ACA to therapeutic complex for the treatment of influenza and other ARVI in children and neonates led to a decrease of the duration of symptoms of intoxication, catarrhal phenomena, and fever as well as to a decrease of the number of complications. The prevention effectiveness of ACA has also been established. The obtained results allow to recommend the use of ACA for the efficient prophylaxis of ARVIs and pneumonia in organized collectives in the period of increased incidences of these infections. Our research has shown that the combined use of drugs with different mechanisms of action - PI ACA and neuraminidase inhibitor Tamiflu - causes a synergistic effect. We also studied the antibacterial action of ACA on S. aureus strains with different sensitivity to antibiotics. ACA inhibits all these strains, and the combined use of ACA with antibiotics magnifies the antibacterial effect

Synthesis and antioxidant and anti-influenza activity of aminomethanesulfonic acids

Aminomethanesulfonic acid (I) and its N-methyl- (II), N-(2-hydroxy)ethyl- (III), N-(tert-butyl)- (IV), N-benzyl- (V), and 4-(N-phenylaminomethyl)phenyl- (VI) derivatives (V and VI not previously reported) were synthesized and characterized by elemental analysis and IR and mass spectroscopy. The in vitro antioxidant activities of aminomethanesulfonic acids I-VI were found to be comparatively weak. Compounds IV and V suppressed statistically significantly reproduction of influenza virus strains A/Hong Kong/1/68 (H3N2) and A/PR/8/34 (H1N1) in chorioallantoic membrane tissue culture