El romance de Góngora en 'El príncipe constante', de Calderón

El caso del gongorino romance “Entre los sueltos caballos,” ampliamente citado en El príncipe constante, de Calderón, resulta excepcional por el tamaño de la cita, nunca igualado por apariciones de versos de otros poetas en las comedias calderonianas. Este trabajo estudia en detalle cómo Calderón adaptó el romance a las circunstancias de la comedia y además resuelve la cuestión de cuál de las versiones del romance gongorino fue la que conoció el dramaturgo madrileño. The case of Góngora’s romance “Entre los sueltos caballos,” extensively quoted in El príncipe constante of Calderón, is exceptional due to the magnitude of the quotation, without equal among the verses of other poets included in Calderonian comedies. This paper studies in detail the ways in which Calderón adapted this romance to the circumstances of his comedy, also resolving the question of which version of Góngora’s romance the Madrid playwright knew

Calderón en la escena y en la imprenta: para la edición crítica de “El príncipe constante”

Debido a la suspensión en la concesión de licencias para imprimir comedias y novelas, las obras calderonianas vivieron varios años sobre las tablas antes de poder estamparse en letra impresa. Levantada ya la prohibición, los avatares que sufrieron en este periodo (diferentes representaciones que generaban diferentes copias del texto según la compañía que lo poseyera, atribuciones falsas, etc.) perjudicaron la labor de recuperación de las comedias por parte del poeta y, en algún caso, mermaron la calidad del texto finalmente impreso. Este hecho se constata aquí a partir del caso particular de “El príncipe constante”, obra que cierra la “Primera parte de comedias” (1636) de don Pedro Calderón. Se trata de una edición descuidada, que dificulta la labor del editor actual, que deberá recurrir a otros testimonios fiables para subsanar los errores de la edición y ofrecer así al lector, en última instancia, un texto lo más cercano posible a la hipotética última voluntad del poeta

Las fechas de 'El Faetonte', de Calderón

El objetivo del presente artículo es estudiar la controvertida fecha de composición y estreno de 'El Faetonte' y otras comedias relacionadas. En el trabajo se revisa igualmente la fortuna escénica de la pieza posterior a la primera representación, contexto en el que se presta especial atención al segundo montaje de la comedia en vida de Calderón, que ha suscitado debate entre la crítica ante la posibilidad de que el propio dramaturgo pudiera haber revisado el texto. The aim of this paper is to study the date of composition and first performance of El Faetonte and related plays.The paper also examines the staging of the play after the first representation. In this context special attention is given to the second performance of 'El Faetonte' for which the playwright could have modified the original play

North American Natural Gas Model Impact of Cross-Border Trade with Mexico

Natural gas as a source of energy has attracted a lot of interest as its emissions rate and price are lower than other fossil fuel energy sources. In the U.S., natural gas-fired power generation has been rising, as coal has declined as a share of the fuel mix. Likewise, Mexico recently launched its energy reform with focus on greatly expanding use of natural gas over other fossil fuels, primarily in the energy sector, by opening the market to private investors. These recent economic and policy changes, along with increasing gas production in the U.S. (shale gas boom) are likely to drive the natural gas market in North America in a new direction. For instance, the Annual Energy Outlook 2015 describes the U.S. for the first time as a net exporter of natural gas (via pipelines and LNG) by 2017. In order to study the current North American gas market with its new regulations like the Mexican energy reform, this paper presents the North American Natural Gas Market Model(NANGAM). We propose a long-term partial-equilibrium model of the United States, Mexican, and Canadian gas markets. NANGAM considers more granular details regarding market regions and pipelines in Mexico than other existing models, allows for endogenous infrastructure expansion, and is built in five year time-steps up to 2040, considering three seasons (low, high, and peak demand) for each time-step. NANGAM is calibrated using up-to-date data, which reflects current gas market trends, such as the increasing U.S. shale gas production. Using NANGAM, we assess the implications of the Mexican energy reform using a set of ad-hoc future scenarios. Results from the model show that, in the case of disappointing development of natural gas production in Mexico, the census region US7 (Texas and adjacent states) is the most affected, reaching an increase of natural gas production of up to 12% by 2040 compared to baseline projections

Functional consequences of seven novel mutations in the CYP11B1 Gene: four mutations associated with nonclassic and three mutations causing classic 11 -Hydroxylase Deficiency

Context: Steroid 11β-hydroxylase (CYP11B1) deficiency (11OHD) is the second most common form of congenital adrenal hyperplasia (CAH). Cases of nonclassic 11OHD are rare compared with the incidence of nonclassic 21-hydroxylase deficiency. Objective: The aim of the study was to analyze the functional consequences of seven novel CYP11B1 mutations (p.M88I, p.W116G, p.P159L, p.A165D, p.K254_A259del, p.R366C, p.T401A) found in three patients with classic 11OHD, two patients with nonclassic 11OHD, and three heterozygous carriers for CYP11B1 mutations. Methods: We conducted functional studies employing a COS7 cell in vitro expression system comparing wild-type (WT) and mutant CYP11B1 activity. Mutants were examined in a computational three-dimensional model of the CYP11B1 protein. Results: All mutations (p.W116G, p.A165D, p.K254_A259del) found in patients with classic 11OHD have absent or very little 11β-hydroxylase activity relative to WT. The mutations detected in patients with nonclassic 11OHD showed partial functional impairment, with one patient being homozygous (p.P159L; 25% of WT) and the other patient compound heterozygous for a novel mild p.M88I (40% of WT) and the known severe p.R383Q mutation. The two mutations detected in heterozygous carriers (p.R366C, p.T401A) also reduced CYP11B1 activity by 23 to 37%, respectively. Conclusion: Functional analysis results allow for the classification of novel CYP11B1 mutations as causative for classic and nonclassic 11OHD, respectively. Four partially inactivating mutations are predicted to result in nonclassic 11OHD. These findings double the number of mild CYP11B1 mutations previously described as associated with mild 11OHD. Our data are important to predict phenotypic expression and provide important information for clinical and genetic counseling i

Improving efficacy of interleukin-12-transfected dendritic cells injected into murine colon cancer with anti-CD137 monoclonal antibodies and alloantigens

Intralesional administration of cultured dendritic cells (DCs) engineered to produce IL-12 by in vitro infection with recombinant adenovirus frequently displays eradicating efficacy against established subcutaneous tumors derived from the CT26 murine colon carcinoma cell line. The elicited response is mainly mediated by cytolytic T lymphocytes. In order to search for strategies that would enhance the efficacy of the therapeutic procedure against less immunogenic tumors, we moved onto malignancies derived from the inoculation of MC38 colon cancer cells that are less prone to undergo complete regression upon a single intratumoral injection of IL-12-secreting DCs. In this model, we found that repeated injections of such DCs, as opposed to a single injection, achieved better efficacy against both the injected and a distantly implanted tumor; that the use of semiallogeneic DCs that are mismatched in one MHC haplotype with the tumor host showed slightly better efficacy; and that the combination of this treatment with systemic injections of immunostimulatory anti-CD137 (4-1BB) monoclonal antibody achieved potent combined effects that correlated with the antitumor immune response measured in IFN-gamma ELISPOT assays. The elicited systemic immune response eradicates concomitant untreated lesions in most cases. Curative efficacy was also found against some tumors established for 2 weeks when these strategies were used in combination. These are preclinical pieces of evidence to be considered in order to enhance the therapeutic benefit of a strategy that is currently being tested in clinical trials. Supplementary Material for this article can be found on the International Journal of Cancer website at http://www.interscience.wiley.com/jpages/0020-7136/suppmat/index.html

Relevance of the coupled channels in the ϕ\phip and ρ0\rho^0p Correlation Functions

The vector meson-baryon interaction in a coupled channel scheme is revisited within the correlation function framework. As illustrative cases to reveal the important role played by the coupled channels, we focus on the $\phi$p and $\rho^0$p systems given their complex dynamics and the presence of quasi-bound states or resonances in the vicinity of their thresholds. We show that the $\phi$p femtoscopic data provide novel information about a $N^*$ state present in the experimental region and anticipate the relevance of a future $\rho^0$p correlation function measurement in order to pin down the $S=0, Q=+1$ vector meson-baryon interaction as well as to disclose the characterizing features of the $N^*(1700)$ state.Comment: 8 pages, 5 figure

Ferromagnetic phase transition in a Heisenberg fluid: Monte Carlo simulations and Fisher corrections to scaling

The magnetic phase transition in a Heisenberg fluid is studied by means of the finite size scaling (FSS) technique. We find that even for larger systems, considered in an ensemble with fixed density, the critical exponents show deviations from the expected lattice values similar to those obtained previously. This puzzle is clarified by proving the importance of the leading correction to the scaling that appears due to Fisher renormalization with the critical exponent equal to the absolute value of the specific heat exponent $\alpha$. The appearance of such new corrections to scaling is a general feature of systems with constraints.Comment: 12 pages, 2 figures; submitted to Phys. Rev. Let