Safety level of damaged RoPax ships : risk modelling and cost-effectiveness analysis

This paper elaborates on results of a recent risk analysis study for RoPax vessels, carried out as part of the activities of the SAFEDOR Integrated Project, targeting possible improvements on safety levels following large scale flooding. The study is based on a comprehensive analysis of accident statistics for the period 1994-2004, through which a high-level risk model (in the form of event trees) is established. This is then used to determine the current safety level of RoPax vessels (in various risk metrics, such as individual risk, potential loss of life and on an F-N curve), reconfirming that even though safety levels are improving, risk is still 'high in the ALARP region'. In search of ways to further improve the situation possible risk control options are examined, by performing a sensitivity analysis on the effects of the Attained Index of Subdivision A onto the safety levels and by evaluating their cost-effectiveness

EL IMPACTO DE LA ACTIVIDAD FÍSICA Y EL DEPORTE SOBRE EL RENDIMIENTO ACADÉMICO: UNA REVISIÓN TEÓRICA/THE IMPACT OF PHYSICAL ACTIVITY AND SPORT ON ACADEMIC PERFORMANCE: A THEORETICAL REVIEW

Las investigaciones acerca de los beneficios de la actividad física y el deporte suelen estar enmarcadas dentro del discurso médico, que propende por la práctica de deporte con miras a disminuir la probabilidad de ocurrencia de patologías de origen cardiaco, respiratorio, metabólico, entre otras. Si bien estos discursos son importantes, por mucho tiempo se ha desconocido, o al menos no se ha reconocido la importancia del deporte en otros contextos de la vida humana. En éste artículo se presenta una serie de investigaciones que hacen evidente los beneficios que el deporte tiene en cuanto a procesos de socialización y de rendimiento escolar de los alumnos que lo practican. PALABRAS CLAVE: Beneficios de la actividad física, actividad mental, deporte. ABSTRACT Research on the benefits of physical activity and sport are often framed within medical discourse, which aims for the practice of sport in order to decrease the likelihood of cardiac pathologies, respiratory, metabolic, among others. While these speeches are important, has long been known, or at least not recognized the importance of sport in other contexts of human life. In this paper we present a series of studies that make clear the benefits that sport has in terms of processes of socialization and academic performance of students who practice it.KEYWORDS: Benefits of physical activity, mental activity, sport.

Estimation of Orofacial Kinematics in Parkinson's Disease: Comparison of 2D and 3D Markerless Systems for Motion Tracking

Orofacial deficits are common in people with Parkinson's disease (PD) and their evolution might represent an important biomarker of disease progression. We are developing an automated system for assessment of orofacial function in PD that can be used in-home or in-clinic and can provide useful and objective clinical information that informs disease management. Our current approach relies on color and depth cameras for the estimation of 3D facial movements. However, depth cameras are not commonly available, might be expensive, and require specialized software for control and data processing. The objective of this paper was to evaluate if depth cameras are needed to differentiate between healthy controls and PD patients based on features extracted from orofacial kinematics. Results indicate that 2D features, extracted from color cameras only, are as informative as 3D features, extracted from color and depth cameras, differentiating healthy controls from PD patients. These results pave the way for the development of a universal system for automatic and objective assessment of orofacial function in PD.Comment: 4 pages, 1 tabl

Теоремы сходимости и компактности для уравнений Бельтрами

Доведено ряд теорем збіжності та компактності класів регулярних розв'язків вироджених рівнянь Бельтрамі з обмеженнями інтегрального типу на дилатацію.A number of convergence and compactness theorems for classes of regular solutions of the degenerate Beltrami equations with restrictions of the integral type on a dilatation is proved

Concurrent Oral 1 - Rheumatoid Arthritis: Treatment [OP4-OP9]: OP4. Inhibition of Radiographic Progression and Improvements in Physical Function at 2 Years, with Increasing Clinical Efficacy Over Time, in Rheumatoid Arthritis (Ra) Patients Treated with Tocilizumab (Tcz): The Lithe Study

Background: Patients with moderate to severe RA who remained on methotrexate (MTX) despite inadequate response were treated with TCZ in a double-blind, randomized, controlled phase 3 trial. Results of a 2-year planned analysis from this study are presented. Methods: Patients were randomized to treatment with TCZ 4 mg/kg + MTX (TCZ4), TCZ 8 mg/kg + MTX (TCZ8) or placebo + MTX (CON) every 4 weeks. If patients failed to respond ( 60% of patients and the DAS28 remission (DAS28 < 2.6) rate was 48% at week 52 and continued to increase to week 104. By week 52, patients treated with TCZ8 had clinically significant improvements in SJC that were maintained through week 104. Rates per 100 PY for adverse events (AEs) were higher in TCZ8 and TCZ4 (263.6, 275.4) vs CON patients (251.4) while rates for serious AEs were comparable (11.4, 12.1, 10.9, respectively). Rates per 100 PY of AEs leading to withdrawal (7.4, 32.5, 4.8) and treatment modification (8.4, 30.7, 20.4) were higher in TCZ8 and TCZ4 vs CON patients, respectively and death rates were comparable (0.6, 0.2, 0.4). Conclusions: Treatment with TCZ + MTX inhibits radiographic progression over 2 years and improves physical function as shown by DAS28 remission, LDAS and low SJC, with a manageable safety profile. Disclosure statement: E.A., F. Hoffmann-La Roche - Employee. P.A., F. Hoffmann-La Roche - Employee. R.B.-V., F. Hoffmann-La Roche - Honoraria. R.F., Genentech - Research Funding, Honoraria. J.K., F. Hoffmann-La Roche - Research funding, Honorari

In the Eye of the Beholder:Changes in Perceived Emotion Expression after Smile Reanimation

Background: Tools to quantify layperson assessments of facial palsy are lacking. In this study, artificial intelligence was applied to develop a proxy for layperson assessments, and compare sensitivity to existing outcome measures. Methods: Artificially intelligent emotion detection software was used to develop the emotionality quotient. The emotionality quotient was defined as the percentage probability of perceived joy over the percentage probability of perceived negative emotions during smiling, as predicted by the software. The emotionality quotient was used to analyze the emotionality of voluntary smiles of normal subjects and unilateral facial palsy patients before and after smile reanimation. The emotionality quotient was compared to oral commissure excursion and layperson assessments of facial palsy patients. Results: In voluntary smiles of 10 normal subjects, 100 percent joy and no negative emotion was detected (interquartile ranges, 0/1). Median preoperative emotionality quotient of 30 facial palsy patients was 15/-60 (interquartile range, 73/62). Postoperatively, median emotionality quotient was 84/0 (interquartile range, 28/5). In 134 smile reanimation patients, no correlation was found between postoperative oral commissure excursion and emotionality quotient score. However, in 61 preoperative patients, a moderate correlation was found between layperson-assessed disfigurement and negative emotion perception (correlation coefficient, 0.516; p <0.001). Conclusions: Computer vision artificial intelligence software detected less joy and more negative emotion in smiles of facial palsy patients compared with normal subjects. Following smile reanimation, significantly more joy and less negative emotion were detected. The emotionality quotient was correlated with layperson assessments. The simplicity, sensitivity, and objectivity of the emotionality quotient render it an attractive tool to serve as a potential proxy for layperson assessment, an ideal outcome measure in facial palsy

Evaluación de la fertilidad masculina en 81 genotipos de la colección colombiana de solanum phureja

81 genotipos de la Colección Colombiana de Solanum phureja, Juz. et Buk. se sembraron para evaluar su fertilidad y la duración de la viabilidad del polen. Las flores se colectaron y se dejaron secar al aire durante 48 horas, luego se extrajo el polen y se guardó en nevera a 7°C. Cada cinco días, se evaluó la fertilidad por el método de germinación "in vitro» y cada 15 días por el método de tinción. Según los resultados, seis genotipos de la colección son estériles y, en general, los genotipos presentan baja fertilidad (menor 20%). El método más adecuado para la estimación de la fertilidad del polen en el tiempo fue la germinación in vitro. Bajo las condiciones de almacenamiento, el polen de la mayoría de los genotipos evaluados tiene un período corto de viabilidad.81 genotypes of the Colombian Collection of Solanum phureja were grown in the field to evaluate fertility and duration of pollen viability. Flowers were Collected and air-dried for 48 hours, then pollen was extracted and kept at 7°C. Fertility was evaluated by the in vitro germination method every five days, and by the stain method every 15 days. Six genotypes of the collection are sterile and, in general, the genotypes have low fertility (less than 20%). The most adequate method to estimate pollen fertility was in vitre germination. Under the storage conditions, the pollen of most genotypes evaluated had a short period of viability