A huge intraductal papillary mucinous carcinoma of the bile duct treated by right trisectionectomy with caudate lobectomy

<p>Abstract</p> <p>Background</p> <p>Because intraductal papillary mucinous neoplasm of the bile duct (IPMN-B) is believed to show a better clinical course than non-papillary biliary neoplasms, it is important to make a precise diagnosis and to perform complete surgical resection.</p> <p>Case presentation</p> <p>We herein report a case of malignant IPMN-B treated by right trisectionectomy with caudate lobectomy and extrahepatic bile duct resection. Radiologic images showed marked dilatation of the left medial sectional bile duct (B4) resulting in a bulky cystic mass with multiple internal papillary projections. Duodenal endoscopic examination demonstrated very patulous ampullary orifice with mucin expulsion and endoscopic retrograde cholangiogram confirmed marked cystic dilatation of B4 with luminal filling defects. These findings suggested IPMN-B with malignancy potential. The functional volume of the left lateral section was estimated to be 45%. A planned extensive surgery was successfully performed. The remnant bile ducts were also dilated but had no macroscopic intraluminal tumorous lesion. The histopathological examination yielded the diagnosis of mucin-producing oncocytic intraductal papillary carcinoma of the bile duct with poorly differentiated carcinomas showing neuroendocrine differentiation. The tumor was 14.0 × 13.0 cm-sized and revealed no stromal invasiveness. Resection margins of the proximal bile duct and hepatic parenchyma were free of tumor cell. The patient showed no postoperative complication and was discharged on 10^thpostoperative date. He has been regularly followed at outpatient department with no evidence of recurrence.</p> <p>Conclusion</p> <p>Considering a favorable prognosis of IPMN-B compared to non-papillary biliary neoplasms, this tumor can be a good indication for aggressive surgical resection regardless of its tumor size.</p

Atomistic simulations of dislocation mobility in Al, Ni and Al/Mg alloys

Dislocation velocities and mobilities are studied by Molecular Dynamics simulations for edge and screw dislocations in pure aluminum and nickel, and edge dislocations in Al-2.5%Mg and Al-5.0%Mg random substitutional alloys using EAM potentials. In the pure materials, the velocities of all dislocations are close to linear with the ratio of (applied stress)/(temperature) at low velocities, consistent with phonon drag models and quantitative agreement with experiment is obtained for the mobility in Al. At higher velocities, different behavior is observed. The edge dislocation velocity remains dependent solely on (applied stress)/(temperature) up to approximately 1.0 MPa/K, and approaches a plateau velocity that is lower than the smallest "forbidden" speed predicted by continuum models. In contrast, above a velocity around half of the smallest continuum wave speed, the screw dislocation damping has a contribution dependent solely on stress with a functional form close to that predicted by a radiation damping model of Eshelby. At the highest applied stresses, there are several regimes of nearly constant (transonic or supersonic) velocity separated by velocity gaps in the vicinity of forbidden velocities; various modes of dislocation disintegration and destabilization were also encountered in this regime. In the alloy systems, there is a temperature- and concentration-dependent pinning regime where the velocity drops sharply below the pure metal velocity. Above the pinning regime but at moderate stresses, the velocity is again linear in (applied stress)/(temperature) but with a lower mobility than in the pure metal.Comment: PDF, 30 pages including figures, submitted to Modelling Simul. Mater. Sci. En

Theoretical and practical knowledge curriculum for European Breast Surgeons

The Breast Surgery theoretical and practical knowledge curriculum comprehensively describes the knowledge and skills expected of a fully trained breast surgeon practicing in the European Union and European Economic Area (EEA). It forms part of a range of factors that contribute to the delivery of high quality cancer care. It has been developed by a panel of experts from across Europe and has been validated by professional breast surgery societies in Europe. The curriculum maps closely to the syllabus of the Union of European Medical Specialists (UEMS) Breast Surgery Exam, the UK FRCS (breast specialist interest) curriculum and other professional standards across Europe and globally (USA Society of Surgical Oncology, SSO). It is envisioned that this will serve as the basis for breast surgery training, examination and accreditation across Europe to harmonise and raise standards as breast surgery develops as a separate discipline from its parent specialties (general surgery, gynaecology, surgical oncology and plastic surgery). The curriculum is not static but will be revised and updated by the curriculum development group of the European Breast Surgical Oncology Certification group (BRESO) every 2 years

European breast surgical oncology certification theoretical and practical knowledge curriculum 2020

The Breast Surgery theoretical and practical knowledge curriculum comprehensively describes the knowledge and skills expected of a fully trained surgeon practicing in the European Union and European Economic Area (EEA). It forms part of a range of factors that contribute to the delivery of high quality cancer care. It has been developed by a panel of experts from across Europe and has been validated by professional breast surgery societies in Europe. The curriculum maps closely to the syllabus of the Union of European Medical Specialists (UEMS) Breast Surgery Exam, the UK FRCS (breast specialist interest) curriculum and other professional standards across Europe and globally (USA Society of Surgical Oncology, SSO). It is envisioned that this will serve as the basis for breast surgery training, examination and accreditation across Europe to harmonise and raise standards as breast surgery develops as a separate discipline from its parent specialties (general surgery, gynaecology, surgical oncology and plastic surgery). The curriculum is not static but will be revised and updated by the curriculum development group of the European Breast Surgical Oncology Certification group (BRESO) every 2 years

Oncoplastic breast consortium recommendations for mastectomy and whole breast reconstruction in the setting of post-mastectomy radiation therapy

Aim Demand for nipple- and skin- sparing mastectomy (NSM/SSM) with immediate breast reconstruction (BR) has increased at the same time as indications for post-mastectomy radiation therapy (PMRT) have broadened. The aim of the Oncoplastic Breast Consortium initiative was to address relevant questions arising with this clinically challenging scenario. Methods A large global panel of oncologic, oncoplastic and reconstructive breast surgeons, patient advocates and radiation oncologists developed recommendations for clinical practice in an iterative process based on the principles of Delphi methodology. Results The panel agreed that surgical technique for NSM/SSM should not be formally modified when PMRT is planned with preference for autologous over implant-based BR due to lower risk of long-term complications and support for immediate and delayed-immediate reconstructive approaches. Nevertheless, it was strongly believed that PMRT is not an absolute contraindication for implant-based or other types of BR, but no specific recommendations regarding implant positioning, use of mesh or timing were made due to absence of high-quality evidence. The panel endorsed use of patient-reported outcomes in clinical practice. It was acknowledged that the shape and size of reconstructed breasts can hinder radiotherapy planning and attention to details of PMRT techniques is important in determining aesthetic outcomes after immediate BR. Conclusions The panel endorsed the need for prospective, ideally randomised phase III studies and for surgical and radiation oncology teams to work together for determination of optimal sequencing and techniques for PMRT for each patient in the context of BR

Field evaluation of soybean cultivars for resistance to whitefly (Bemisia tabaci Genn.) infestations

Whitefly is one of the major yield reducing insect pests of soybean in the Mediterranean region. This study was conducted to screen soybean cultivars, taken from germplasm centers and private seed companies (USA), against the whitefly in the Mediterranean region after wheat harvest in between 1976 and 2005. No artificial infestation was made since whiteflies were very abundant. The whitefly observation was made in August which is the time of the heaviest infestation. Ten plants from each plot and three leaves from each plant (lower, medium and upper parts) were taken for investigation of whitefly population. Eggs, larvae and pupae numbers were determined on the leaves. Seventy two cultivars were found to be highly resistant, 46 cultivars resistant, 43 cultivars moderately resistant, 23 cultivars susceptible and 18 cultivars highly susceptible. Understanding of genetic control of resistance to whitefly can enhance development of resistant cultivars that could be grown in whitefly infested areas. © 2010 Academic Journals

Effects of some plant growth regulators and nutrient complexes on pod shattering and yield losses of soybean under hot and dry conditions

This study was carried out to determine the effects of four Plant Growth Regulators (PGRs) (Atonik, GA 3, Cytozyme Crop Extra and Megahix), two nutrient complexes (Biomaster and Kinetic) and a see weed extract (Maxicrop) on pod-shattering rate and yield loss of both main and double-cropped soybean grown in a prolonged hot and dry condition in 2002 and 2003. The soybean cultivar was A 3935. The experimental design was randomized complete block with four replications. Application of PGRs remarkably lowered the shattering rates and seed yield losses only for main-cropped soybean. The lowest shattering rates and yield losses were obtained from Atonik and Cytozyme applications until 10 days after R8 growth stage for main-cropped soybean. The positive effects of PGRs on shattering rate and yield losses were decreased with the increasing delay of harvest. The results of the current study showed that seed yield losses of main-cropped soybean could be alleviated by the application of Atonik, Megahix and Cytozyme. However application of PGRs was not suggested for double-cropped soybean if the scope was to reduce yield losses caused by pod shattering. © 2006 Asian Network for Scientific Information

Oil content and composition of soybean genotypes grown in different growing seasons under Mediterranean conditions

Aim : Methodology : Results : Interpretation : Soybean is a strategic crop plant grown to obtain edible oil and forage. Oil content and fatty acid composition of oilseeds are important consideration for breeding programs. This study was conducted to determinate fatty acid compositions of some soybean varieties grown in both main and double cropping system at the University of Cukurova,Turkey in 2013 and 2014 growing seasons. The experiment was designed in a Randomized Complete Block with three replications. Soybean varieties Atakisi,Ar soy, Cinsoy,Adasoy, Ilksoy,Turksoy,Ataem-7, Sa 88, S 4240, Blaze and Nova (maturity group III and IV) were used as a plant material. Oil content and fatty acid (palmitic, stearic, oleic, linoleic and linolenic acids) compositions of soybean varieties were investigated. According to a two-year average, the fatty acid composition of soybean varieties ranged from 10.59-12.09% for palmitic acid, 3.11-4.52% for stearic acid, 27.02-34.09% for oleic acid, 44.51-51.80% for linoleic, and 4.44-5.61% for linolenic acid in main cropped soybean. In double cropped soybean, the fatty acid composition (two-year average) of the tested varieties ranged from 10.76-12.23% for palmitic acid, 3.94-4.87% for stearic acid, 22.69-29.51% for oleic acid, 48.40-54.14% for linoleic and 5.41-6.62% for linolenic, respectively. The oil and oleic acid content was found higher in main cropped than double cropped growing season, but the linoleic acid contentwashigher in double cropped than in main cropped growing seasons. © Triveni Enterprises, Lucknow (India)This work was supported by the Atlas Seed Company, Adana-Turkey. We would like to express our sincere thanks and appreciation to Serdar Mart, General Director of Seed Company. Also, we would especially like to thank Dr. Mehmet Erdogmus for his technical assistance, The Black Sea Research Institute, Samsun-Turke

Effects of some plant growth regulators and nutrient complexes on above-ground biomass and seed yield of soybean grown under heat-stressed environment

A two-year study was conducted to determine the effects of some Plant Growth Regulators (PGRs) and nutrient complexes on biomass weight, seed yield and yield components of both main and double cropped soybean grown under hot and dry conditions. The experimental design was Randomized Complete Block with four replications. Atonik, Biomaster, GA3, Kinetic, Maxicrop, Cytozyme and Megahix were used as plant growth regulators. The soybean cultivar was A3935 (MG III). Application of PGRs had different effects on biomass weight, seed yield and yield components of both main and double cropped soybean. The highest biomass weight (1054.0 g-2) was obtained from Maxicrop and the lowest (891.8 g-2) was obtained from Megahix applied plots in main cropped soybean. Under double crop conditions, however, the highest biomass weight (857.6 g-2) was obtained from Cytozyme and the lowest (780.0 g -2) was obtained from control. Application of PGRs increased the seed yield and yield components of soybean under both main and double cropped conditions. The highest seed yield was obtained from Atonik with 3876 kg ha -1 for main crop soybean and 3447 kg ha-1 for double cropped soybean. The lowest seed yields were obtained from no chemical applied control plots of both main and double cropped soybean with 3386 and 2838 kg ha-1, respectively. Application of Atonik, Cytozyme and Maxicrop could be suggested to alleviate heat stress and increase seed yield of both main and double cropped soybean grown under hot and dry conditions. © 2006 Asian Network for Scientific Information