3,330 research outputs found

    Generalized Green'S Equivalences on the Subsemigroups of the Bicyclic Monoid

    Get PDF
    We study generalized Green's equivalences on all subsemigroups of the bicyclic monoid B and determine the abundant (and adequate) subsemigroups of B. © 2010 Copyright Taylor and Francis Group, LLC

    Predicting dissatisfaction following total knee replacement:a prospective study of 1217 patients

    Get PDF
    Up to 20% of patients are not satisfied with the outcome following total knee replacement (TKR). This study investigated the pre- and post-operative predictors of dissatisfaction in a large cohort of patients undergoing TKR. We assessed 1217 consecutive patients between 2006 and 2008 both before operation and six months after, using the Short-form (SF)-12 health questionnaire and the Oxford Knee Score. Detailed information concerning comorbidity was also gathered. Satisfaction was measured at one year when 18.6% (226 of 1217) of patients were unsure or dissatisfied with their replacement and 81.4% (911 of 1217) were satisfied or very satisfied. Multivariate regression analysis was performed to identify independent predictors of dissatisfaction. Significant (p &lt; 0.001) predictors at one year included the pre-operative SF-12 mental component score, depression and pain in other joints, the six-month SF-12 score and poorer improvement in the pain element of the Oxford Knee Score. Patient expectations were highly correlated with satisfaction. Satisfaction following TKR is multifactorial. Managing the expectations and mental health of the patients may reduce dissatisfaction. However, the most significant predictor of dissatisfaction is a painful total knee replacement.</p

    Regulatory T Cells Are Dispensable for Tolerance to RBC Antigens

    Get PDF
    Autoimmune hemolytic anemia (AIHA) occurs when pathogenic autoantibodies against red blood cell (RBC) antigens are generated. Whilst the basic disease pathology of AIHA is well studied, the underlying mechanism(s) behind the failure in tolerance to RBC autoantigens are poorly understood. Thus, to investigate the tolerance mechanisms required for the establishment and maintenance of tolerance to RBC antigens, we developed a novel murine model. With this model, we evaluated the role of regulatory T cells (Tregs) in tolerance to RBC-specific antigens. Herein, we show that neither sustained depletion of Tregs nor immunization with RBC-specific proteins in conjunction with Treg depletion led to RBC-specific autoantibody generation. Thus, these studies demonstrate that Tregs are not required to prevent autoantibodies to RBCs and suggest that other tolerance mechanisms are likely involved

    Markov semigroups, monoids, and groups

    Full text link
    A group is Markov if it admits a prefix-closed regular language of unique representatives with respect to some generating set, and strongly Markov if it admits such a language of unique minimal-length representatives over every generating set. This paper considers the natural generalizations of these concepts to semigroups and monoids. Two distinct potential generalizations to monoids are shown to be equivalent. Various interesting examples are presented, including an example of a non-Markov monoid that nevertheless admits a regular language of unique representatives over any generating set. It is shown that all finitely generated commutative semigroups are strongly Markov, but that finitely generated subsemigroups of virtually abelian or polycyclic groups need not be. Potential connections with word-hyperbolic semigroups are investigated. A study is made of the interaction of the classes of Markov and strongly Markov semigroups with direct products, free products, and finite-index subsemigroups and extensions. Several questions are posed.Comment: 40 pages; 3 figure

    Viewpoints of adolescents with overweight and obesity attending lifestyle obesity treatment interventions : a qualitative systematic review

    Get PDF
    Background Current UK guidance recommends that adolescents with obesity attend a family-based multi-component obesity intervention. However, these programmes suffer from low recruitment and high rates of attrition. Understanding the views of adolescents is necessary for developing future interventions. The aim of this systematic review was to synthesise and explore the views of adolescents who have attended an obesity intervention. Methods Published literature was identified by searching six databases. Studies of adolescents (12-17 years) who attended an obesity intervention were examined. Only studies that collected and analysed data qualitatively were included. Full-texts were analysed using thematic synthesis. Results Twenty-eight studies were included. Thirty-five analytical themes were developed that were broadly divided into seven domains. Key themes included ensuring adolescents receive a ‘tailored intervention’ that involves ‘active engagement’. Support from professionals, family and peers was valued highly. Adolescents expressed ‘prior fears of attending interventions’ and wanted ‘longer-term support’. ‘Enjoyment of sport and physical activity’ was evident and adolescents were strongly motivated by improving body image and social desirability. Discussion Considering the views of adolescents attending obesity interventions may help to inform policy makers in the development of future interventions. This may lead to an improvement in recruitment and attrition rates

    Risk of cancer following primary total hip replacement or primary resurfacing arthroplasty of the hip : A retrospective cohort study in Scotland

    Get PDF
    Acknowledgements: We are grateful to Lee Barnsdale, Doug Clark, and Richard Dobbie for advice and assistance with data preparation before analysis, and to the three anonymous referees for their helpful comments and suggestions.Peer reviewedPublisher PD

    Optical Spectra of 73 Stripped-Envelope Core-Collapse Supernovae

    Full text link
    We present 645 optical spectra of 73 supernovae (SNe) of Types IIb, Ib, Ic, and broad-lined Ic. All of these types are attributed to the core collapse of massive stars, with varying degrees of intact H and He envelopes before explosion. The SNe in our sample have a mean redshift = 4200 km/s. Most of these spectra were gathered at the Harvard-Smithsonian Center for Astrophysics (CfA) between 2004 and 2009. For 53 SNe, these are the first published spectra. The data coverage range from mere identification (1-3 spectra) for a few SNe to extensive series of observations (10-30 spectra) that trace the spectral evolution for others, with an average of 9 spectra per SN. For 44 SNe of the 73 SNe presented here, we have well-determined dates of maximum light to determine the phase of each spectrum. Our sample constitutes the most extensive spectral library of stripped-envelope SNe to date. We provide very early coverage (as early as 30 days before V-band max) for photospheric spectra, as well as late-time nebular coverage when the innermost regions of the SNe are visible (as late as 2 years after explosion, while for SN1993J, we have data as late as 11.6 years). This data set has homogeneous observations and reductions that allow us to study the spectroscopic diversity of these classes of stripped SNe and to compare these to SNe associated with gamma-ray bursts. We undertake these matters in follow-up papers.Comment: Published by the Astronomical Journal in May 2015. All spectra are publicly available at the CfA SN archive: http://www.cfa.harvard.edu/supernova/SNarchive.html . A companion paper on constructing SNID templates based on these spectra is by Liu & Modjaz (2014) and the resulting SNID templates are available from the NYU website: http://cosmo.nyu.edu/SNYU/spectra

    Intra-individual movement variability during skill transitions: A useful marker?

    Get PDF
    Applied research suggests athletes and coaches need to be challenged in knowing when and how much a movement should be consciously attended to. This is exacerbated when the skill is in transition between two more stable states, such as when an already well learnt skill is being refined. Using existing theory and research, this paper highlights the potential application of movement variability as a tool to inform a coach’s decision-making process when implementing a systematic approach to technical refinement. Of particular interest is the structure of co-variability between mechanical degrees-of-freedom (e.g., joints) within the movement system’s entirety when undergoing a skill transition. Exemplar data from golf are presented, demonstrating the link between movement variability and mental effort as an important feature of automaticity, and thus intervention design throughout the different stages of refinement. Movement variability was shown to reduce when mental effort directed towards an individual aspect of the skill was high (target variable). The opposite pattern was apparent for variables unrelated to the technical refinement. Therefore, two related indicators, movement variability and mental effort, are offered as a basis through which the evaluation of automaticity during technical refinements may be made

    Scottish theme towns: have new identities enhanced development?

    Get PDF
    Three small towns in southwest Scotland have recently been branded as distinct theme towns, based on books, artists and food. This is an attempt to make them more attractive to visitors and thereby improve their economy. The objective of this research is to establish whether the new identities possessed by the towns have enhanced their development. It is argued, using data reviewing the past decade, that they have all developed, albeit at different rates, in terms of the economy and culture. Moreover, it is maintained that social capital has been enhanced and is a factor whose importance has been under-appreciated by planners and observers of this type of process. The relevance of the new identity to the pre-branding identity is also seen as a factor in successful development and ideas of authenticity and heritage are brought to bear on the relationship

    Practices of readiness: punctuation, poise and the contingencies of participatory design

    Get PDF
    How do we ready ourselves to intervene responsively in the contingent situations that arise in co-designing to make change? How do we attune to group dynamics and respond ethically to unpredictable developments when working with ‘community’? Participatory Design (PD) can contribute to social transitions, yet its focus is often tightly tuned to technique for designing ICT at the cost of participatory practice. We challenge PD conventions by addressing what happens as we step into a situation to alter it with others, an aspect of practice that cannot be replicated or interchanged. We do so to argue that practices of readiness are constituted by personal histories, experiences, philosophies and culture. We demonstrate this political argument by giving reflexive accounts of our dimensions of preparation. The narratives here are distinct, yet reveal complementary theories and worldviews that shape PD ontologies. We have organized these around the qualities of punctuation and poise as a way to draw out some less easily articulated aspects of PD practice
    corecore