Medication adherence in patients with myotonic dystrophy and facioscapulohumeral muscular dystrophy

Myotonic dystrophy (DM) and facioscapulohumeral muscular dystrophy (FSHD) are the two most common adult muscular dystrophies and have progressive and often disabling manifestations. Higher levels of medication adherence lead to better health outcomes, especially important to patients with DM and FSHD because of their multisystem manifestations and complexity of care. However, medication adherence has not previously been studied in a large cohort of DM type 1 (DM1), DM type 2 (DM2), and FSHD patients. The purpose of our study was to survey medication adherence and disease manifestations in patients enrolled in the NIH-supported National DM and FSHD Registry. The study was completed by 110 DM1, 49 DM2, and 193 FSHD patients. Notable comorbidities were hypertension in FSHD (44 %) and DM2 (37 %), gastroesophageal reflux disease in DM1 (24 %) and DM2 (31 %) and arrhythmias (29 %) and thyroid disease (20 %) in DM1. Each group reported high levels of adherence based on regimen complexity, medication costs, health literacy, side effect profile, and their beliefs about treatment. Only dysphagia in DM1 was reported to significantly impact medication adherence. Approximately 35 % of study patients reported polypharmacy (taking 6 or more medications). Of the patients with polypharmacy, the DM1 cohort was significantly younger (mean 55.0 years) compared to DM2 (59.0 years) and FSHD (63.2 years), and had shorter disease duration (mean 26 years) compared to FSHD (26.8 years) and DM2 (34.8 years). Future research is needed to assess techniques to ease pill swallowing in DM1 and to monitor polypharmacy and potential drug interactions in DM and FSHD

The Effects of Supplementing Wet Distillers Grains Mixed With Wheat Straw to Growing Steers

A growing study compared feeding wet distillers grains, dried distillers grains, and a mix of 66% wet distillers grains and 33% wheat straw as supplements to a forage-based diet. Steers were supplemented 0, 2, 4, or 6 lb distillers grains/head daily. Wet distillers grains and dried distillers grains produced higher final body weight and dry matter intake compared to the mix. Increasing levels of distillers grains increased performance in forage based diets and wet grains mixed with straw reduced forage intake

The Effects of Supplementing Wet Distillers Grains Mixed With Wheat Straw to Growing Steers

A growing study compared feeding wet distillers grains, dried distillers grains, and a mix of 66% wet distillers grains and 33% wheat straw as supplements to a forage-based diet. Steers were supplemented 0, 2, 4, or 6 lb distillers grains/head daily. Wet distillers grains and dried distillers grains produced higher final body weight and dry matter intake compared to the mix. Increasing levels of distillers grains increased performance in forage based diets and wet grains mixed with straw reduced forage intake

Site and Extent of Digestion of Finishing Diets Containing Syngenta Enhanced Feed Corn

Four ruminally and duodenally fistulated steers were utilized to evaluate the effects of Syngenta Enhanced Feed Corn™ containing an alpha amylase enzyme trait (SYT- EFC) compared to the isoline parental control corn without the alpha amylase enzyme trait (Negative Isoline) on site and extent of digestion in finishing diets. Cattle fed SYT- EFC dry rolled corn had numerically greater postruminal starch digestibility, excreted lower fecal starch, and had greater total tract starch digestibility compared to cattle fed Negative Isoline corn. These data would suggest that cattle are able to utilize more starch from corn containing the SYT- EFC trait, which has resulted in greater gains and efficiencies

Impact of Feeding Distillers Grains With or Without Oil Removal As Well As Supplemental Corn Oil on Nutrient Digestibility by Finishing Cattle

A digestion trial was conducted to determine the effects of the removal of corn oil from modified distillers grains plus solubles (MDGS) and the impact of supplemental corn oil on finishing cattle nutrient digestion. Four treatments were evaluated: a corn control diet (CON), 40% de-oiled MDGS (DO MDGS), or 38% de-oiled MDGS plus 2% corn oil (MDGS + Oil) formulated to equal the fat content of FF MDGS, or 40% full fat MDGS (FF MDGS). Treatment differences were observed for digestibility of dry matter, organic matter, and fiber, but not for fat. When oil was added to de-oiled MDGS, digestibility was decreased for dry matter, organic matter, and fiber when compared to de-oiled or full fat MDGS. Digestibility values from feeding DGS relative to corn control diets do not follow the same trend, digestible energy increases with DGS feeding, but OM digestibility decreases with DGS feeding

Evaluation of Protein from Distillers Grains in Finishing Diets on Nutrient Digestibility

A metabolism trial was conducted to evaluate protein from modified distillers grains plus solubles (MDGS) in finishing diets on nutrient digestibility and ruminal fermentation characteristics. Isolated protein from corn was not different than MDGS for dry matter, organic matter, or neutral detergent fiber digestibility. However, steers fed MDGS tended to have lower total tract organic matter digestibility compared to corn and protein from corn. Protein had greater total tract organic matter and starch digestibility than MDGS. Protein from corn did not contribute towards the lower digestibility of MDGS. Protein is more easily digestible than the other components in distillers grains plus solubles

Impact of Syngenta Enogen Feed Corn on Finishing Cattle Performance and Carcass Characteristics

Two finishing experiments were conducted to evaluate Syngenta Enogen Feed Corn containing an alpha amylase enzyme trait compared to the near negative isoline control corn at two locations on cattle performance and carcass characteristics. No statistical differences were observed for final BW, DMI, ADG, or F:G for steers fed Syngenta Enogen Feed Corn versus the near negative isoline control corn. Fat depth and calculated yield grade were greater for steers fed Syngenta Enogen Feed Corn; however, HCW and marbling scores were not different. Previous research has observed a 2.6% to 16.4% decrease in F:G when Syngenta Enogen Feed Corn was fed; however, under this study a 1.6% reduction in F:G was observed

Evaluation of Protein from Distillers Grains in Finishing Diets on Nutrient Digestibility

A metabolism trial was conducted to evaluate protein from modified distillers grains plus solubles (MDGS) in finishing diets on nutrient digestibility and ruminal fermentation characteristics. Isolated protein from corn was not different than MDGS for dry matter, organic matter, or neutral detergent fiber digestibility. However, steers fed MDGS tended to have lower total tract organic matter digestibility compared to corn and protein from corn. Protein had greater total tract organic matter and starch digestibility than MDGS. Protein from corn did not contribute towards the lower digestibility of MDGS. Protein is more easily digestible than the other components in distillers grains plus solubles

Effect of Distillers Grains Composition and Level on Steers Consuming High-Quality Forage

An experiment was conducted to determine the effects of dried distillers grains (DDG) supplementation level and composition on growing steer performance and forage intake. Factors included DDG supplementation level (0.25, 0.50, 0.75 or 1.00% of BW), and DDG solubles level (0, 5.4, 14.5, 19.1, or 22.1% DM). Final BW improved, and forage intake decreased with increasing levels of DDG. An interaction between DDG supplementation level and solubles level was observed on ADG and F:G and was likely related to supplemental fat levels. Supplementation of forages with DDG improves performance while decreasing forage intake when fat levels are not too great

Potential link between caffeine consumption and pediatric depression: A case-control study

<p>Abstract</p> <p>Background</p> <p>Early-onset depressive disorders can have severe consequences both from developmental and functional aspects. The etiology of depressive disorders is complex and multi-factorial, with an intricate interaction among environmental factors and genetic predisposition. While data from studies on adults suggest that caffeine is fairly safe, effects of caffeine in children, who are in period of rapid brain development, are currently unknown. Furthermore, systematic research addressing the relationship between depressive symptoms in children and caffeine consumption is lacking.</p> <p>The present study examined the effects of caffeine consumption on depressed mood in children with depression and non-depressed participants.</p> <p>Methods</p> <p>Children and adolescents (n = 51) already enrolled in an ongoing longitudinal study, aged 9-12 years, were assessed for depressive symptoms with the Children Depressive Inventory (CDI). Psychopathological symptoms were assessed with the Child Behavioral Checklist (CBCL) and eating habits were assessed with the Nutrition-Behavior Inventory (NBI) <abbrgrp><abbr bid="B1">1</abbr></abbrgrp>. The children were compared to control children without psychopathology attending public schools in a Southern Brazilian city.</p> <p>Results</p> <p>Participants with CDI scores ≥ 15 (mean = 19; S.D. = 4) also had high NBI scores (mean = 52; S.D. = 19, p < 0.001) suggestive of a relationship between depressive symptoms and environmental factors, in this case nutrition/behavior. Additional linear regression adjusted statistical analysis, considering the factors of consumption of sweets and caffeine individually, showed that caffeine, but not sweets, was associated with depressive symptoms.</p> <p>Conclusions</p> <p>These findings indicate that depressed children consume more caffeinated drinks than non-depressed children. Nonetheless while a strong association between depressive symptoms and caffeine consumption among children was found, further research should investigate whether or not this association is due to a cause and effect relationship.</p