Dispersion monitoring for high-speed WDM networks via two-photon absorption in a semiconductor microcavity

Due to the continued demand for bandwidth, network operators have to increase the data rates at which individual wavelengths operate at. As these data rates will exceed 100 Gbit/s in the next 5-10 years, it will be crucial to be able to monitor and compensate for the amount of chromatic dispersion encountered by individual wavelength channels. This paper will focus on the use of the novel nonlinear optical-to-electrical conversion process of two-photon absorption (TPA) for dispersion monitoring. By incorporating a specially designed semiconductor microcavity, the TPA response becomes wavelength dependent, thus allowing simultaneous channel selection and monitoring without the need for external wavelength filterin

Separation of variables in quasi-potential systems of bi-cofactor form

We perform variable separation in the quasi-potential systems of equations of the form $\ddot{q}=-A^{-1}\nabla k=-\tilde{A}^{-1}\nabla\tilde{k}${}, where $A$ and $\tilde{A}$ are Killing tensors, by embedding these systems into a bi-Hamiltonian chain and by calculating the corresponding Darboux-Nijenhuis coordinates on the symplectic leaves of one of the Hamiltonian structures of the system. We also present examples of the corresponding separation coordinates in two and three dimensions.Comment: LaTex, 30 pages, to appear in J. Phys. A: Math. Ge

Endoplasmic reticulum polymers impair luminal protein mobility and sensitize to cellular stress in alpha1-antitrypsin deficiency.

UNLABELLED: Point mutants of alpha1 -antitrypsin (α1AT) form ordered polymers that are retained as inclusions within the endoplasmic reticulum (ER) of hepatocytes in association with neonatal hepatitis, cirrhosis, and hepatocellular carcinoma. These inclusions cause cell damage and predispose to ER stress in the absence of the classical unfolded protein response (UPR). The pathophysiology underlying this ER stress was explored by generating cell models that conditionally express wild-type (WT) α1AT, two mutants that cause polymer-mediated inclusions and liver disease (E342K [the Z allele] and H334D) and a truncated mutant (Null Hong Kong; NHK) that induces classical ER stress and is removed by ER-associated degradation. Expression of the polymeric mutants resulted in gross changes in the ER luminal environment that recapitulated the changes observed in liver sections from individuals with PI*ZZ α1AT deficiency. In contrast, expression of NHK α1AT caused electron lucent dilatation and expansion of the ER throughout the cell. Photobleaching microscopy in live cells demonstrated a decrease in the mobility of soluble luminal proteins in cells that express E342K and H334D α1AT, when compared to those that express WT and NHK α1AT (0.34 ± 0.05, 0.22 ± 0.03, 2.83 ± 0.30, and 2.84 ± 0.55 μm(2) /s, respectively). There was no effect on protein mobility within ER membranes, indicating that cisternal connectivity was not disrupted. Polymer expression alone was insufficient to induce the UPR, but the resulting protein overload rendered cells hypersensitive to ER stress induced by either tunicamycin or glucose depletion. CONCLUSION: Changes in protein diffusion provide an explanation for the cellular consequences of ER protein overload in mutants that cause inclusion body formation and α1AT deficiency

Mapping the X-Ray Emission Region in a Laser-Plasma Accelerator

The x-ray emission in laser-plasma accelerators can be a powerful tool to understand the physics of relativistic laser-plasma interaction. It is shown here that the mapping of betatron x-ray radiation can be obtained from the x-ray beam profile when an aperture mask is positioned just beyond the end of the emission region. The influence of the plasma density on the position and the longitudinal profile of the x-ray emission is investigated and compared to particle-in-cell simulations. The measurement of the x-ray emission position and length provides insight on the dynamics of the interaction, including the electron self-injection region, possible multiple injection, and the role of the electron beam driven wakefield.Comment: 5 pages, 4 figure

α1-Antitrypsin deficiency.

α1-Antitrypsin deficiency (A1ATD) is an inherited disorder caused by mutations in SERPINA1, leading to liver and lung disease. It is not a rare disorder but frequently goes underdiagnosed or misdiagnosed as asthma, chronic obstructive pulmonary disease (COPD) or cryptogenic liver disease. The most frequent disease-associated mutations include the S allele and the Z allele of SERPINA1, which lead to the accumulation of misfolded α1-antitrypsin in hepatocytes, endoplasmic reticulum stress, low circulating levels of α1-antitrypsin and liver disease. Currently, there is no cure for severe liver disease and the only management option is liver transplantation when liver failure is life-threatening. A1ATD-associated lung disease predominately occurs in adults and is caused principally by inadequate protease inhibition. Treatment of A1ATD-associated lung disease includes standard therapies that are also used for the treatment of COPD, in addition to the use of augmentation therapy (that is, infusions of human plasma-derived, purified α1-antitrypsin). New therapies that target the misfolded α1-antitrypsin or attempt to correct the underlying genetic mutation are currently under development

A class of Poisson-Nijenhuis structures on a tangent bundle

Equipping the tangent bundle TQ of a manifold with a symplectic form coming from a regular Lagrangian L, we explore how to obtain a Poisson-Nijenhuis structure from a given type (1,1) tensor field J on Q. It is argued that the complete lift of J is not the natural candidate for a Nijenhuis tensor on TQ, but plays a crucial role in the construction of a different tensor R, which appears to be the pullback under the Legendre transform of the lift of J to co-tangent manifold of Q. We show how this tangent bundle view brings new insights and is capable also of producing all important results which are known from previous studies on the cotangent bundle, in the case that Q is equipped with a Riemannian metric. The present approach further paves the way for future generalizations.Comment: 22 page

Factors Associated with Veteran Patients Decisions About Advance Directives at the Minnesota VAMC

An estimated 30 million Americans are potentially eligible for care within the Veteran\u27s Administration system. To better understand how veterans choose whether or not to complete an advance directive this study obtained self-reports from eleven men on an extended care ward, at a local VA. An exploratory study was conducted using a questionnaire that gathered quantitative and qualitative data regarding demographics, reasons for having or not having an advance directive, and preferred learning methods. Consistent with other research, the findings indicated varied reasons for not having an advance directive including: never received information, never thought about it, procrastination, family already knows what the patients preferences are. Recommendations for a higher completion rate of advance directives include providing patient videos on the topic and one-on-one meetings with patients and family members to explain advance directives

Brokering words and work: complexities of literacy sponsorship in the oilfields of south Texas.

This research is an investigation of workforce recruitment language as the “leading edge” of literacy sponsorship as it pertains to blue-collar rig and service workers in the South Texas oilfields. Using Deborah Brandt’s Literacy in American Lives as a framework for this study, I conducted interviews with 10 rig and service workers and labor market intermediary administrators about the perceptions and expectations of literacy use in oilfield work. My inquiry begins by first learning about workers’ experiences with recruitment into the industry. Then, to understand more about how the industry communicates literacy expectations to these workers, I look at recruitment rhetoric via a rhetorical analysis of job advertisements for oil and gas positions. Finally, I examine the role of job market labor market intermediaries (LMIs), or temp agencies, and the role they play in potential oil and gas workers coming into the industry. The results of this research are what make up my dissertation “Brokering Words and Work: Complexities of Literacy Sponsorship in the Oilfields of South Texas” in which I argue that literacy use is influenced by two significant factors. The first factor is the cultural and technological shift in the industry as it pertains to the 2012-13 hydraulic fracturing boom in the Eagle Ford Shale region of South Texas. This particular boom aligns with the Great Crew Change, the mass retirement of workers from oil and gas positions, creating a need for more workers at all levels of the industry, including workers with advanced technical skills and academic education. To recruit for these new literacies and skills, the industry communicates needs through job advertisements, which, I argue, are as much gatekeepers as they are matchmakers between work and workers for reasons related to access. The second factor is the normalizing of literacy-based processes by the in industry, especially as it pertains to workforce materials, such as reading and interpreting job advertisements, filling out job applications, and resume work. As the culture shifts from networking to the utilization of online job applications and materials, workers and/or applicants not familiar with these genres need assistance navigating the literacy expectations required to use them. To assist in labor market education practices, the industry utilizes the services of labor market intermediaries, which, I argue, are used to bridge literacy and accessibility gaps between worker and industry

(16) Psyche: A mesosiderite-like asteroid?

Asteroid (16) Psyche is the target of the NASA Psyche mission. It is considered one of the few main-belt bodies that could be an exposed proto-planetary metallic core and that would thus be related to iron meteorites. Such an association is however challenged by both its near- and mid-infrared spectral properties and the reported estimates of its density. Here, we aim to refine the density of (16) Psyche to set further constraints on its bulk composition and determine its potential meteoritic analog. We observed (16) Psyche with ESO VLT/SPHERE/ZIMPOL as part of our large program (ID 199.C-0074). We used the high angular resolution of these observations to refine Psyche's three-dimensional (3D) shape model and subsequently its density when combined with the most recent mass estimates. In addition, we searched for potential companions around the asteroid. We derived a bulk density of 3.99\,$\pm$\,0.26\,g$\cdot$cm$^{-3}$ for Psyche. While such density is incompatible at the 3-sigma level with any iron meteorites ($\sim$7.8\,g$\cdot$cm$^{-3}$), it appears fully consistent with that of stony-iron meteorites such as mesosiderites (density $\sim$4.25\,$\cdot$cm$^{-3}$). In addition, we found no satellite in our images and set an upper limit on the diameter of any non-detected satellite of 1460\,$\pm$\,200}\,m at 150\,km from Psyche (0.2\%\,$\times$\,R$_{Hill}$, the Hill radius) and 800\,$\pm$\,200\,m at 2,000\,km (3\%\,$\times$\,$R_{Hill}$). Considering that the visible and near-infrared spectral properties of mesosiderites are similar to those of Psyche, there is merit to a long-published initial hypothesis that Psyche could be a plausible candidate parent body for mesosiderites.Comment: 16 page