Children’s preference for HAS and LOCATED relations: A word learning bias for noun–noun compounds

The present study investigates children’s bias when interpreting novel noun–noun compounds (e.g. kig donka) that refer to combinations of novel objects (kig and donka). More specifically, it investigates children’s understanding of modifier–head relations of the compounds and their preference for HAS or LOCATED relations (e.g. a donka that HAS a kig or a donka that is LOCATED near a kig) rather than a FOR relation (e.g. a donka that is used FOR kigs). In a forced-choice paradigm, two- and three-year-olds preferred interpretations with HAS/LOCATED relations, while five-year-olds and adults showed no preference for either interpretation. We discuss possible explanations\ud for this preference and its relation to another word learning bias that is based on perceptual features of the referent objects, i.e. the shape bias. We argue that children initially focus on a perceptual stability rather than a pure conceptual stability when interpreting the meaning of nouns

Matrix String Theory and its Moduli Space

The correspondence between Matrix String Theory in the strong coupling limit and IIA superstring theory can be shown by means of the instanton solutions of the former. We construct the general instanton solutions of Matrix String Theory which interpolate between given initial and final string configurations. Each instanton is characterized by a Riemann surface of genus h with n punctures, which is realized as a plane curve. We study the moduli space of such plane curves and find out that, at finite N, it is a discretized version of the moduli space of Riemann surfaces: instead of 3h-3+n its complex dimensions are 2h-3+n, the remaining h dimensions being discrete. It turns out that as $N$ tends to infinity, these discrete dimensions become continuous, and one recovers the full moduli space of string interaction theory.Comment: 30 pages, LaTeX, JHEP.cls class file, minor correction

Loss of testosterone impairs anti-tumor neutrophil function.

In men, the incidence of melanoma rises rapidly after age 50, and nearly two thirds of melanoma deaths are male. The immune system is known to play a key role in controlling the growth and spread of malignancies, but whether age- and sex-dependent changes in immune cell function account for this effect remains unknown. Here, we show that in castrated male mice, neutrophil maturation and function are impaired, leading to elevated metastatic burden in two models of melanoma. Replacement of testosterone effectively normalized the tumor burden in castrated male mice. Further, the aberrant neutrophil phenotype was also observed in prostate cancer patients receiving androgen deprivation therapy, highlighting the evolutionary conservation and clinical relevance of the phenotype. Taken together, these results provide a better understanding of the role of androgen signaling in neutrophil function and the impact of this biology on immune control of malignancies

String Interactions from Matrix String Theory

The Matrix String Theory, i.e. the two dimensional U(N) SYM with N=(8,8) supersymmetry, has classical BPS solutions that interpolate between an initial and a final string configuration via a bordered Riemann surface. The Matrix String Theory amplitudes around such a classical BPS background, in the strong Yang--Mills coupling, are therefore candidates to be interpreted in a stringy way as the transition amplitude between given initial and final string configurations. In this paper we calculate these amplitudes and show that the leading contribution is proportional to the factor g_s^{-\chi}, where \chi is the Euler characteristic of the interpolating Riemann surface and g_s is the string coupling. This is the factor one expects from perturbative string interaction theory.Comment: 15 pages, 2 eps figures, JHEP Latex class, misprints correcte

On Integrable Systems and Supersymmetric Gauge Theories

The properties of the N=2 SUSY gauge theories underlying the Seiberg-Witten hypothesis are discussed. The main ingredients of the formulation of the finite-gap solutions to integrable equations in terms of complex curves and generating 1-differential are presented, the invariant sense of these definitions is illustrated. Recently found exact nonperturbative solutions to N=2 SUSY gauge theories are formulated using the methods of the theory of integrable systems and where possible the parallels between standard quantum field theory results and solutions to integrable systems are discussed.Comment: LaTeX, 38 pages, no figures; based on the lecture given at INTAS School on Advances in Quantum Field Theory and Statistical Mechanics, Como, Italy, 1996; minor changes, few references adde

Maximal surface group representations in isometry groups of classical Hermitian symmetric spaces

Higgs bundles and non-abelian Hodge theory provide holomorphic methods with which to study the moduli spaces of surface group representations in a reductive Lie group G. In this paper we survey the case in which G is the isometry group of a classical Hermitian symmetric space of non-compact type. Using Morse theory on the moduli spaces of Higgs bundles, we compute the number of connected components of the moduli space of representations with maximal Toledo invariant.Comment: v2: added due credits to the work of Burger, Iozzi and Wienhard. v3: corrected count of connected components for G=SU(p,q) (p \neq q); added due credits to the work of Xia and Markman-Xia; minor corrections and clarifications. 31 page

Semantic memory redux: an experimental test of hierarchical category representation

Four experiments investigated the classic issue in semantic memory of whether people organize categorical information in hierarchies and use inference to retrieve information from them, as proposed by Collins & Quillian (1969). Past evidence has focused on RT to confirm sentences such as “All birds are animals” or “Canaries breathe.” However, confounding variables such as familiarity and associations between the terms have led to contradictory results. Our experiments avoided such problems by teaching subjects novel materials. Experiment 1 tested an implicit hierarchical structure in the features of a set of studied objects (e.g., all brown objects were large). Experiment 2 taught subjects nested categories of artificial bugs. In Experiment 3, subjects learned a tree structure of novel category hierarchies. In all three, the results differed from the predictions of the hierarchical inference model. In Experiment 4, subjects learned a hierarchy by means of paired associates of novel category names. Here we finally found the RT signature of hierarchical inference. We conclude that it is possible to store information in a hierarchy and retrieve it via inference, but it is difficult and avoided whenever possible. The results are more consistent with feature comparison models than hierarchical models of semantic memory

Stable isotope analysis provides new information on winter habitat use of declining avian migrants that is relevant to their conservation

Winter habitat use and the magnitude of migratory connectivity are important parameters when assessing drivers of the marked declines in avian migrants. Such information is unavailable for most species. We use a stable isotope approach to assess these factors for three declining African-Eurasian migrants whose winter ecology is poorly known: wood warbler Phylloscopus sibilatrix, house martin Delichon urbicum and common swift Apus apus. Spatially segregated breeding wood warbler populations (sampled across a 800 km transect), house martins and common swifts (sampled across a 3,500 km transect) exhibited statistically identical intra-specific carbon and nitrogen isotope ratios in winter grown feathers. Such patterns are compatible with a high degree of migratory connectivity, but could arise if species use isotopically similar resources at different locations. Wood warbler carbon isotope ratios are more depleted than typical for African-Eurasian migrants and are compatible with use of moist lowland forest. The very limited variance in these ratios indicates specialisation on isotopically restricted resources, which may drive the similarity in wood warbler populations' stable isotope ratios and increase susceptibility to environmental change within its wintering grounds. House martins were previously considered to primarily use moist montane forest during the winter, but this seems unlikely given the enriched nature of their carbon isotope ratios. House martins use a narrower isotopic range of resources than the common swift, indicative of increased specialisation or a relatively limited wintering range; both factors could increase house martins' vulnerability to environmental change. The marked variance in isotope ratios within each common swift population contributes to the lack of population specific signatures and indicates that the species is less vulnerable to environmental change in sub-Saharan Africa than our other focal species. Our findings demonstrate how stable isotope research can contribute to understanding avian migrants' winter ecology and conservation status

Oxaliplatin induces drug resistance more rapidly than cisplatin in H69 small cell lung cancer cells

Cisplatin produces good responses in solid tumours including small cell lung cancer (SCLC) but this is limited by the development of resistance. Oxaliplatin is reported to show activity against some cisplatin-resistant cancers but there is little known about oxaliplatin in SCLC and there are no reports of oxaliplatin resistant SCLC cell lines. Studies of drug resistance mainly focus on the cellular resistance mechanisms rather than how the cells develop resistance. This study examines the development of cisplatin and oxaliplatin resistance in H69 human SCLC cells in response to repeated treatment with clinically relevant doses of cisplatin or oxaliplatin for either 4 days or 2h. Treatments with 200ng/ml cisplatin or 400ng/ml oxaliplatin for 4 days produced sublines (H69CIS200 and H69OX400 respectively) that showed low level (approximately 2-fold) resistance after 8 treatments. Treatments with 1000ng/ml cisplatin or 2000ng/ml oxaliplatin for 2h also produced sublines, however these were not stably resistant suggesting shorter treatment pulses of drug may be more effective. Cells survived the first five treatments without any increase in resistance, by arresting their growth for a period and then regrowing. The period of growth arrest was reduced after the sixth treatment and the H69CIS200 and H69OX400 sublines showed a reduced growth arrest in response to cisplatin and oxaliplatin treatment suggesting that "regrowth resistance" initially protected against drug treatment and this was further upregulated and became part of the resistance phenotype of these sublines. Oxaliplatin dose escalation produced more surviving sublines than cisplatin dose escalation but neither set of sublines were associated with increased resistance as determined by 5-day cytotoxicity assays, also suggesting the involvement of regrowth resistance. The resistant sublines showed no change in platinum accumulation or glutathione levels even though the H69OX400 subline was more sensitive to buthionine sulfoximine treatment. The H69CIS200 cells were cross-resistant to oxaliplatin demonstrating that oxaliplatin does not have activity against low level cisplatin resistance. Relative to the H69 cells, the H69CIS200 and H69OX400 sublines were more sensitive to paclitaxel and taxotere suggests the taxanes may be useful in the treatment of platinum resistant SCLC. These novel cellular models of cisplatin and oxaliplatin resistant SCLC will be useful in developing strategies to treat platinum-resistant SCLC