Reversibility of Red blood Cell deformation

The ability of cells to undergo reversible shape changes is often crucial to their survival. For Red Blood Cells (RBCs), irreversible alteration of the cell shape and flexibility often causes anemia. Here we show theoretically that RBCs may react irreversibly to mechanical perturbations because of tensile stress in their cytoskeleton. The transient polymerization of protein fibers inside the cell seen in sickle cell anemia or a transient external force can trigger the formation of a cytoskeleton-free membrane protrusion of micrometer dimensions. The complex relaxation kinetics of the cell shape is shown to be responsible for selecting the final state once the perturbation is removed, thereby controlling the reversibility of the deformation. In some case, tubular protrusion are expected to relax via a peculiar "pearling instability".Comment: 4 pages, 3 figure

Dynamic Modes of Microcapsules in Steady Shear Flow: Effects of Bending and Shear Elasticities

The dynamics of microcapsules in steady shear flow was studied using a theoretical approach based on three variables: The Taylor deformation parameter $\alpha_{\rm D}$, the inclination angle $\theta$, and the phase angle $\phi$ of the membrane rotation. It is found that the dynamic phase diagram shows a remarkable change with an increase in the ratio of the membrane shear and bending elasticities. A fluid vesicle (no shear elasticity) exhibits three dynamic modes: (i) Tank-treading (TT) at low viscosity $\eta_{\rm {in}}$ of internal fluid ($\alpha_{\rm D}$ and $\theta$ relaxes to constant values), (ii) Tumbling (TB) at high $\eta_{\rm {in}}$ ($\theta$ rotates), and (iii) Swinging (SW) at middle $\eta_{\rm {in}}$ and high shear rate $\dot\gamma$ ($\theta$ oscillates). All of three modes are accompanied by a membrane ($\phi$) rotation. For microcapsules with low shear elasticity, the TB phase with no $\phi$ rotation and the coexistence phase of SW and TB motions are induced by the energy barrier of $\phi$ rotation. Synchronization of $\phi$ rotation with TB rotation or SW oscillation occurs with integer ratios of rotational frequencies. At high shear elasticity, where a saddle point in the energy potential disappears, intermediate phases vanish, and either $\phi$ or $\theta$ rotation occurs. This phase behavior agrees with recent simulation results of microcapsules with low bending elasticity.Comment: 11 pages, 14 figure

Rubidium and lead abundances in giant stars of the globular clusters M 13 and NGC 6752

We present measurements of the neutron-capture elements Rb and Pb in five giant stars of the globular cluster NGC 6752 and Pb measurements in four giants of the globular cluster M 13. The abundances were derived by comparing synthetic spectra with high resolution, high signal-to-noise ratio spectra obtained using HDS on the Subaru telescope and MIKE on the Magellan telescope. The program stars span the range of the O-Al abundance variation. In NGC 6752, the mean abundances are [Rb/Fe] = -0.17 +/- 0.06 (sigma = 0.14), [Rb/Zr] = -0.12 +/- 0.06 (sigma = 0.13), and [Pb/Fe] = -0.17 +/- 0.04 (sigma = 0.08). In M 13 the mean abundance is [Pb/Fe] = -0.28 +/- 0.03 (sigma = 0.06). Within the measurement uncertainties, we find no evidence for a star-to-star variation for either Rb or Pb within these clusters. None of the abundance ratios [Rb/Fe], [Rb/Zr], or [Pb/Fe] are correlated with the Al abundance. NGC 6752 may have slightly lower abundances of [Rb/Fe] and [Rb/Zr] compared to the small sample of field stars at the same metallicity. For M 13 and NGC 6752 the Pb abundances are in accord with predictions from a Galactic chemical evolution model. If metal-poor intermediate-mass asymptotic giant branch stars did produce the globular cluster abundance anomalies, then such stars do not synthesize significant quantities of Rb or Pb. Alternatively, if such stars do synthesize large amounts of Rb or Pb, then they are not responsible for the abundance anomalies seen in globular clusters.Comment: Accepted for publication in Ap

Exploring Millions of 6-State FSSP Solutions: the Formal Notion of Local CA Simulation

In this paper, we come back on the notion of local simulation allowing to transform a cellular automaton into a closely related one with different local encoding of information. This notion is used to explore solutions of the Firing Squad Synchronization Problem that are minimal both in time (2n -- 2 for n cells) and, up to current knowledge, also in states (6 states). While only one such solution was proposed by Mazoyer since 1987, 718 new solutions have been generated by Clergue, Verel and Formenti in 2018 with a cluster of machines. We show here that, starting from existing solutions, it is possible to generate millions of such solutions using local simulations using a single common personal computer

Dynamical regimes and hydrodynamic lift of viscous vesicles under shear

The dynamics of two-dimensional viscous vesicles in shear flow, with different fluid viscosities $\eta_{\rm in}$ and $\eta_{\rm out}$ inside and outside, respectively, is studied using mesoscale simulation techniques. Besides the well-known tank-treading and tumbling motions, an oscillatory swinging motion is observed in the simulations for large shear rate. The existence of this swinging motion requires the excitation of higher-order undulation modes (beyond elliptical deformations) in two dimensions. Keller-Skalak theory is extended to deformable two-dimensional vesicles, such that a dynamical phase diagram can be predicted for the reduced shear rate and the viscosity contrast $\eta_{\rm in}/\eta_{\rm out}$. The simulation results are found to be in good agreement with the theoretical predictions, when thermal fluctuations are incorporated in the theory. Moreover, the hydrodynamic lift force, acting on vesicles under shear close to a wall, is determined from simulations for various viscosity contrasts. For comparison, the lift force is calculated numerically in the absence of thermal fluctuations using the boundary-integral method for equal inside and outside viscosities. Both methods show that the dependence of the lift force on the distance $y_{\rm {cm}}$ of the vesicle center of mass from the wall is well described by an effective power law $y_{\rm {cm}}^{-2}$ for intermediate distances $0.8 R_{\rm p} \lesssim y_{\rm {cm}} \lesssim 3 R_{\rm p}$ with vesicle radius $R_{\rm p}$. The boundary-integral calculation indicates that the lift force decays asymptotically as $1/[y_{\rm {cm}}\ln(y_{\rm {cm}})]$ far from the wall.Comment: 13 pages, 13 figure

K band Spectroscopy of Ultraluminous Infrared Galaxies: The 2 Jy Sample

We present near-infrared spectroscopy for a complete sample of 33 ultraluminous infrared galaxies at a resolution of R\approx 1000. Most of the wavelength range from 1.80-2.20 microns in the rest frame is covered, including the Pa-alpha and Br-gamma hydrogen recombination lines, and the molecular hydrogen vibration-rotation 1-0 S(1) and S(3) lines. Other species, such as He I, [Fe II], and [Si VI] appear in the spectra as well, in addition to a number of weaker molecular hydrogen lines. Nuclear extractions for each of the individual galaxies are presented here, along with spectra of secondary nuclei, where available. The Pa-alpha emission is seen to be highly concentrated on the nuclei, typically with very little emision extending beyond a radius of 1 kpc. Signatures of active nuclei are rare in the present sample, occurring in only two of the 33 galaxies. It is found that visual extinctions to the nuclei via the Pa-alpha/Br-gamma line ratio in excess of 10 magnitudes are relatively common among ULIRGs, and that visual extinctions greater than 25 mag are necessary to conceal a QSO emitting half the total bolometric luminosity. The vibration-rotation lines of molecular hydrogen appear to be predominantly thermal in origin, with effective temperatures generally around 2200 K. The relative nuclear velocities between double nucleus ULIRGs are investigated, through which it is inferred that the maximum deprojected velocity difference is about 200 km/s. This figure is lower than the velocities predicted by physical models of strong interactions/mergers of large, gas-rich galaxies.Comment: 52 pages (19 with just figures), 9 figures, accepted for publication in the Astronomical Journal; Table 3 not formatted properly on astro-ph: get source and print Murphy.tab3.p

Eye movements in strategic choice

In risky and other multiattribute choices, the process of choosing is well described by random walk or drift diffusion models in which evidence is accumulated over time to threshold. In strategic choices, level-k and cognitive hierarchy models have been offered as accounts of the choice process, in which people simulate the choice processes of their opponents or partners. We recorded the eye movements in 2 × 2 symmetric games including dominance-solvable games like prisoner's dilemma and asymmetric coordination games like stag hunt and hawk–dove. The evidence was most consistent with the accumulation of payoff differences over time: we found longer duration choices with more fixations when payoffs differences were more finely balanced, an emerging bias to gaze more at the payoffs for the action ultimately chosen, and that a simple count of transitions between payoffs—whether or not the comparison is strategically informative—was strongly associated with the final choice. The accumulator models do account for these strategic choice process measures, but the level-k and cognitive hierarchy models do not

Eye movements in strategic choice

In risky and other multiattribute choices, the process of choosing is well described by random walk or drift diffusion models in which evidence is accumulated over time to threshold. In strategic choices, level-k and cognitive hierarchy models have been offered as accounts of the choice process, in which people simulate the choice processes of their opponents or partners. We recorded the eye movements in 2 × 2 symmetric games including dominance-solvable games like prisoner's dilemma and asymmetric coordination games like stag hunt and hawk–dove. The evidence was most consistent with the accumulation of payoff differences over time: we found longer duration choices with more fixations when payoffs differences were more finely balanced, an emerging bias to gaze more at the payoffs for the action ultimately chosen, and that a simple count of transitions between payoffs—whether or not the comparison is strategically informative—was strongly associated with the final choice. The accumulator models do account for these strategic choice process measures, but the level-k and cognitive hierarchy models do not

The Distribution of Bar and Spiral Strengths in Disk Galaxies

The distribution of bar strengths in disk galaxies is a fundamental property of the galaxy population that has only begun to be explored. We have applied the bar/spiral separation method of Buta, Block, and Knapen to derive the distribution of maximum relative gravitational bar torques, Q_b, for 147 spiral galaxies in the statistically well-defined Ohio State University Bright Galaxy Survey (OSUBGS) sample. Our goal is to examine the properties of bars as independently as possible of their associated spirals. We find that the distribution of bar strength declines smoothly with increasing Q_b, with more than 40% of the sample having Q_b <= 0.1. In the context of recurrent bar formation, this suggests that strongly-barred states are relatively short-lived compared to weakly-barred or non-barred states. We do not find compelling evidence for a bimodal distribution of bar strengths. Instead, the distribution is fairly smooth in the range 0.0 <= Q_b < 0.8. Our analysis also provides a first look at spiral strengths Q_s in the OSU sample, based on the same torque indicator. We are able to verify a possible weak correlation between Q_s and Q_b, in the sense that galaxies with the strongest bars tend also to have strong spirals.Comment: Accepted for publication in the Astronomical Journal, August 2005 issue (LaTex, 23 pages + 11 figures, uses aastex.cls