Is there a link between treatments with exogenous corticosteroids and dog behaviour problems?

Possible side effects of exogenous corticosteroids have been described in both humans and laboratory animals, with recent studies highlighting this issue in dogs. In this paper the behaviour of 345 dogs drawn from the caseload of a behaviour clinic based in the north of Italy between February 2012 and November 2014 were analysed. Possible relationships between dogs that received treatment with corticosteroids versus dogs that received treatment with drugs other than corticosteroids and positive or negative affective states, aggression towards people, other behaviour problems apart from aggression, occurrence of severe bites, and prescription of psychoactive drugs were initially assessed using a Pearson's chi-squared test. Regression analysis was then performed in order to evaluate the best predictors of the investigated items. The goal of this retrospective survey was to investigate possible relationships between the affective states associated with the behavioural complaint of dogs and their previous history of treatment with corticosteroids. Results showed that a history of corticosteroid treatment was a significant predictor of a range of behaviour problems associated with negative affective state, but this result may be confounded by age-related effects

Effect of inhomogeneities on the expansion rate of the Universe

While the expansion rate of a homogeneous isotropic Universe is simply proportional to the square-root of the energy density, the expansion rate of an inhomogeneous Universe also depends on the nature of the density inhomogeneities. In this paper we calculate to second order in perturbation variables the expansion rate of an inhomogeneous Universe and demonstrate corrections to the evolution of the expansion rate. While we find that the mean correction is small, the variance of the correction on the scale of the Hubble radius is sensitive to the physical significance of the unknown spectrum of density perturbations beyond the Hubble radius.Comment: 19 pages, 2 figures Version 2 includes some changes in numerical factors and corrected typos. It is the version accepted for publication in Physical review

"Swiss-Cheese" Inhomogeneous Cosmology & the Dark Energy Problem

We study an exact swiss-cheese model of the Universe, where inhomogeneous LTB patches are embedded in a flat FLRW background, in order to see how observations of distant sources are affected. We find negligible integrated effect, suppressed by (L/R_{H})^3 (where L is the size of one patch, and R_{H} is the Hubble radius), both perturbatively and non-perturbatively. We disentangle this effect from the Doppler term (which is much larger and has been used recently \cite{BMN} to try to fit the SN curve without dark energy) by making contact with cosmological perturbation theory.Comment: 35 pages, 6 figure

Design and analysis of fractional factorial experiments from the viewpoint of computational algebraic statistics

We give an expository review of applications of computational algebraic statistics to design and analysis of fractional factorial experiments based on our recent works. For the purpose of design, the techniques of Gr\"obner bases and indicator functions allow us to treat fractional factorial designs without distinction between regular designs and non-regular designs. For the purpose of analysis of data from fractional factorial designs, the techniques of Markov bases allow us to handle discrete observations. Thus the approach of computational algebraic statistics greatly enlarges the scope of fractional factorial designs.Comment: 16 page

Detecting the Cold Spot as a Void with the Non-Diagonal Two-Point Function

The anomaly in the Cosmic Microwave Background known as the "Cold Spot" could be due to the existence of an anomalously large spherical (few hundreds Mpc/h radius) underdense region, called a "Void" for short. Such a structure would have an impact on the CMB also at high multipoles l through Lensing. This would then represent a unique signature of a Void. Modeling such an underdensity with an LTB metric, we show that the Lensing effect leads to a large signal in the non-diagonal two-point function, centered in the direction of the Cold Spot, such that the Planck satellite will be able to confirm or rule out the Void explanation for the Cold Spot, for any Void radius with a Signal-to-Noise ratio of at least O(10).Comment: v1: 6 pages, 2 figures; v2: 6 pages, 2 figures, text improved, to appear on JCA

Cosmological Backreaction from Perturbations

We reformulate the averaged Einstein equations in a form suitable for use with Newtonian gauge linear perturbation theory and track the size of the modifications to standard Robertson-Walker evolution on the largest scales as a function of redshift for both Einstein de-Sitter and Lambda CDM cosmologies. In both cases the effective energy density arising from linear perturbations is of the order of 10^-5 the matter density, as would be expected, with an effective equation of state w ~ -1/19. Employing a modified Halofit code to extend our results to quasilinear scales, we find that, while larger, the deviations from Robertson-Walker behaviour remain of the order of 10^-5.Comment: 15 pages, 8 figures; replaced by version accepted by JCA

Axino dark matter from thermal production

The axino is a promising candidate for dark matter in the Universe. It is electrically and color neutral, very weakly interacting, and could be - as assumed in this study - the lightest supersymmetric particle, which is stable for unbroken R-parity. In supersymmetric extensions of the standard model, in which the strong CP problem is solved via the Peccei-Quinn mechanism, the axino arises naturally as the fermionic superpartner of the axion. We compute the thermal production rate of axinos in supersymmetric QCD. Using hard thermal loop resummation, we obtain a finite result in a gauge-invariant way, which takes into account Debye screening in the hot quark-gluon-squark-gluino plasma. The relic axino abundance from thermal scatterings after inflation is evaluated. We find that thermally produced axinos could provide the dominant part of cold dark matter, for example, for an axino mass of 100 keV and a reheating temperature of 10^6 GeV.Comment: 33 pages, 7 figures, 1 table, erratum adde

Cosmic Acceleration Driven by Mirage Inhomogeneities

A cosmological model based on an inhomogeneous D3-brane moving in an AdS_5 X S_5 bulk is introduced. Although there is no special points in the bulk, the brane Universe has a center and is isotropic around it. The model has an accelerating expansion and its effective cosmological constant is inversely proportional to the distance from the center, giving a possible geometrical origin for the smallness of a present-day cosmological constant. Besides, if our model is considered as an alternative of early time acceleration, it is shown that the early stage accelerating phase ends in a dust dominated FRW homogeneous Universe. Mirage-driven acceleration thus provides a dark matter component for the brane Universe final state. We finally show that the model fulfills the current constraints on inhomogeneities.Comment: 14 pages, 1 figure, IOP style. v2, changed style, minor corrections, references added, version accepted in Class. Quant. Gra

An inhomogeneous universe with thick shells and without cosmological constant

We build an exact inhomogeneous universe composed of a central flat Friedmann zone up to a small redshift $z_1$, a thick shell made of anisotropic matter, an hyperbolic Friedmann metric up to the scale where dimming galaxies are observed ($z\simeq 1.7$) that can be matched to a hyperbolic Lema\^{i}tre-Tolman-Bondi spacetime to best fit the WMAP data at early epochs. We construct a general framework which permits us to consider a non-uniform clock rate for the universe. As a result, both for a uniform time and a uniform Hubble flow, the deceleration parameter extrapolated by the central observer is always positive. Nevertheless, by taking a non-uniform Hubble flow, it is possible to obtain a negative central deceleration parameter, that, with certain parameter choices, can be made the one observed currently. Finally, it is conjectured a possible physical mechanism to justify a non-uniform time flow.Comment: Version published in Class. Quantum gra