Anti-angiogenic therapies for the treatment of angiosarcoma: a clinical update

Summary: Angiosarcomas are rare aggressive endothelial tumours, and are associated with a poor prognosis. Due to their vascular nature, there is great interest in their response to anti-angiogenic agents. A number of small prospective studies have reported angiosarcoma response to vascular-targeted agents, including agents that target vascular endothelial growth factor. To date, the response to these agents has been disappointing, and similar to the response observed in other soft tissue sarcoma subtypes. This short review will summarise the recent data in this field

Application of modulated chlorophyll fluorescence and modulated chlorophyll fluorescence imaging to study the environmental stress effect

Chlorophyll (Chl) a fluorescence is a widely used tool to monitor the photosynthetic process in plants subjected to environmental stresses. this review reports the theoretical bases of Chl fluorescence, and the significance of the most important Chl fluorescence parameters. it also reports how these parameters can be utilised to estimate changes in photosystem (Ps) ii photochemistry, linear electron flux and dissipation mechanisms. the relation between actual Psii photochemistry and Co2 assimilation is discussed, as is the role of photochemical and non-photochemical quenching in inducing changes in Psii activity. the application of Chl fluorescence imaging to study heterogeneity on leaf lamina is also considered. this review summarises only some of the results obtained by this methodology to study the effects of different environmental stresses, namely water availability, nutrients, pollutants, temperature and salinity

Caracterización agronómica-morfológica de 6 entradas de "tomaca tipo masclet" de la colección de variedades tradicionales del IVIA

[ES] En el presente trabajo se muestran las características morfológicas y de interés agronómico del fruto, correspondientes a 6 entradas de tomate valenciano perteneciente a la colección de variedades tradicionales del IVIA. Las 6 entradas son: IVIA-2 (origen Moncada); IVIA-27 (origen Siete Aguas); IVIA-28 (origen Paiporta); IVIA-69 (origen Moncada); IVIA-72 (origen Moncada); IVIA-126 (origen El Perelló). Respecto a la arquitectura de la planta, las 6 entradas son similares. La diferencia más importante entre ellas es debido a la morfología del fruto; tanto en su sección longitudinal, número de lóculos y el peso medio de los frutos. Las entradas con el extremo distal del fruto con forma puntiaguda, característica muy apreciada por los consumidores, son las IVIA-27 e IVIA-69. Por otro lado, IVIA-28, presenta el mayor peso medio de los frutos con un valor de 262g con una gran calidad, aunque la forma del fruto es menos puntiaguda que ninguno de los otros. Las 6 entradas presentan un gran potencial agronómico dado que presentan un tamaño, forma y color de fruto atrayentes dentro de los cánones de la denominación del tomate valenciano.[EN] In the present work we present the morphological and agronomical interest characteristics of 6 accessions of Valencian tomato from the IVIA traditional varieties collection. The 6 accesions are: IVIA-2 (origin Moncada); IVIA-27 (origin Siete Aguas); IVIA-28 (origin Paiporta); IVIA-69 (origin Moncada); IVIA-72 (origin Moncada); IVIA-126 (origin El Perelló). Regarding plant architecture, the 6 accessions are similar. The most important difference among them is due to the fruit morphology; in particular in its longitudinal section, number of locules and mean fruit weight. The accessions with the distal part of the fruit more pointed, a characteristic very appreciated by consumers, are IVIA-27 and IVIA-69. On the other side, IVIA-28 has the greatest fruit size with a value of 262g and a great quality, although the fruit shape is less pointed than any of the others. The 6 accessions have a great agronomic potential as they have an attractive fruit size, shape and color within the typical characteristics of the denomination Valencian tomato.El equipo de horticultura del IVIA agradece a la Conselleria d`Agricultura, Medi Ambient, Canvi Climatic i Desenvolupament Rural por el soporte y ayuda para el mantenimiento de la colección de variedades tradicionales valencianas del IVIA.Marsal, J.; Cerdá, J.; López Serrano, L.; Penella, C.; Calatayud Chover, Á. (2020). Caracterización agronómica-morfológica de 6 entradas de "tomaca tipo masclet" de la colección de variedades tradicionales del IVIA. En I Congrés de la Tomaca Valenciana: La Tomaca Valenciana d'El Perelló. Editorial Universitat Politècnica de València. 65-71. https://doi.org/10.4995/TOMAVAL2017.2017.6320OCS657

Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes.

Although several lung cancer susceptibility loci have been identified, much of the heritability for lung cancer remains unexplained. Here 14,803 cases and 12,262 controls of European descent were genotyped on the OncoArray and combined with existing data for an aggregated genome-wide association study (GWAS) analysis of lung cancer in 29,266 cases and 56,450 controls. We identified 18 susceptibility loci achieving genome-wide significance, including 10 new loci. The new loci highlight the striking heterogeneity in genetic susceptibility across the histological subtypes of lung cancer, with four loci associated with lung cancer overall and six loci associated with lung adenocarcinoma. Gene expression quantitative trait locus (eQTL) analysis in 1,425 normal lung tissue samples highlights RNASET2, SECISBP2L and NRG1 as candidate genes. Other loci include genes such as a cholinergic nicotinic receptor, CHRNA2, and the telomere-related genes OFBC1 and RTEL1. Further exploration of the target genes will continue to provide new insights into the etiology of lung cancer

Obesity, Metabolic Factors and Risk of Different Histological Types of Lung Cancer: A Mendelian Randomization Study

Background: Assessing the relationship between lung cancer and metabolic conditions is challenging because of the confounding effect of tobacco. Mendelian randomization (MR), or the use of genetic instrumental variables to assess causality, may help to identify the metabolic drivers of lung cancer. Methods and findings: We identified genetic instruments for potential metabolic risk factors and evaluated these in relation to risk using 29,266 lung cancer cases (including 11,273 adenocarcinomas, 7,426 squamous cell and 2,664 small cell cases) and 56,450 controls. The MR risk analysis suggested a causal effect of body mass index (BMI) on lung cancer risk for two of the three major histological subtypes, with evidence of a risk increase for squamous cell carcinoma (odds ratio (OR) [95% confidence interval (CI)] = 1.20 [1.01–1.43] and for small cell lung cancer (OR [95%CI] = 1.52 [1.15–2.00]) for each standard deviation (SD) increase in BMI [4.6 kg/m2]), but not for adenocarcinoma (OR [95%CI] = 0.93 [0.79–1.08]) (Pheterogeneity = 4.3x10-3). Additional analysis using a genetic instrument for BMI showed that each SD increase in BMI increased cigarette consumption by 1.27 cigarettes per day (P = 2.1x10-3), providing novel evidence that a genetic susceptibility to obesity influences smoking patterns. There was also evidence that low-density lipoprotein cholesterol was inversely associated with lung cancer overall risk (OR [95%CI] = 0.90 [0.84–0.97] per SD of 38 mg/dl), while fasting insulin was positively associated (OR [95%CI] = 1.63 [1.25–2.13] per SD of 44.4 pmol/l). Sensitivity analyses including a weighted-median approach and MR-Egger test did not detect other pleiotropic effects biasing the main results. Conclusions: Our results are consistent with a causal role of fasting insulin and low-density lipoprotein cholesterol in lung cancer etiology, as well as for BMI in squamous cell and small cell carcinoma. The latter relation may be mediated by a previously unrecognized effect of obesity on smoking behavior

Protein-altering germline mutations implicate novel genes related to lung cancer development

Few germline mutations are known to affect lung cancer risk. We performed analyses of rare variants from 39,146 individuals of European ancestry and investigated gene expression levels in 7,773 samples. We find a large-effect association with an ATM L2307F (rs56009889) mutation in adenocarcinoma for discovery (adjusted Odds Ratio = 8.82, P = 1.18 × 10−15) and replication (adjusted OR = 2.93, P = 2.22 × 10−3) that is more pronounced in females (adjusted OR = 6.81 and 3.19 and for discovery and replication). We observe an excess loss of heterozygosity in lung tumors among ATM L2307F allele carriers. L2307F is more frequent (4%) among Ashkenazi Jewish populations. We also observe an association in discovery (adjusted OR = 2.61, P = 7.98 × 10−22) and replication datasets (adjusted OR = 1.55, P = 0.06) with a loss-of-function mutation, Q4X (rs150665432) of an uncharacterized gene, KIAA0930. Our findings implicate germline genetic variants in ATM with lung cancer susceptibility and suggest KIAA0930 as a novel candidate gene for lung cancer risk

Frequently asked questions about chlorophyll fluorescence, the sequel

[EN] Using chlorophyll (Chl) a fluorescence many aspects of the photosynthetic apparatus can be studied, both in vitro and, noninvasively, in vivo. Complementary techniques can help to interpret changes in the Chl a fluorescence kinetics. Kalaji et al. (Photosynth Res 122: 121-158, 2014a) addressed several questions about instruments, methods and applications based on Chl a fluorescence. Here, additionalChl a fluorescence-related topics are discussed again in a question and answer format. 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