Will we observe black holes at LHC?

The generalized uncertainty principle, motivated by string theory and non-commutative quantum mechanics, suggests significant modifications to the Hawking temperature and evaporation process of black holes. For extra-dimensional gravity with Planck scale O(TeV), this leads to important changes in the formation and detection of black holes at the the Large Hadron Collider. The number of particles produced in Hawking evaporation decreases substantially. The evaporation ends when the black hole mass is Planck scale, leaving a remnant and a consequent missing energy of order TeV. Furthermore, the minimum energy for black hole formation in collisions is increased, and could even be increased to such an extent that no black holes are formed at LHC energies.Comment: 5 pages, 2 figures. Minor changes to match version to appear in Class. Quant. Gra

Graviton production with 2 jets at the LHC in large extra dimensions

We study Kaluza-Klein (KK) graviton production in the large extra dimensions model via 2 jets plus missing transverse momentum signatures at the LHC. We make predictions for both the signal and the dominant Zjj and Wjj backgrounds, where we introduce missing P_T-dependent jet selection cuts that ensure the smallness of the 2-jet rate over the 1-jet rate. With the same jet selection cuts, the distributions of the two jets and their correlation with the missing transverse momentum provide additional evidence for the production of an invisible massive object.Comment: 8 pages, 10 figures, 1 table; Version to be printed in JHE

Black Holes at Future Colliders and Beyond: a Topical Review

One of the most dramatic consequences of low-scale (~1 TeV) quantum gravity in models with large or warped extra dimension(s) is copious production of mini black holes at future colliders and in ultra-high-energy cosmic ray collisions. Hawking radiation of these black holes is expected to be constrained mainly to our three-dimensional world and results in rich phenomenology. In this topical review we discuss the current status of astrophysical observations of black holes and selected aspects of mini black hole phenomenology, such as production at colliders and in cosmic rays, black hole decay properties, Hawking radiation as a sensitive probe of the dimensionality of extra space, as well as an exciting possibility of finding new physics in the decays of black holes.Comment: 31 pages, 10 figures To appear in the Journal of Physics

Access to justice for all: Towards an “expansive vision” of justice and technology.

In this paper, the authors examine developments in the Canadian access to justice dialogue from Macdonald’s seminal 2005 analysis to the recent reports of the National Action Committee on Access to Justice in Civil and Family Matters [NAC]. They draw on the NAC’s call for an “expansive vision” of access to justice as the basis for critically evaluating examples of particular technologies used or proposed as responses to the access to justice crisis in Canada. In so doing, they illustrate the importance of conscious consideration of deliverables and beneficiaries in prioritizing technologies for deployment, in determining how the technology ought to be deployed, and in evaluating the potential of a technology to facilitate access to justice. The authors argue that nuanced accounts of the relationships between justice deliverables, technological mechanisms for delivery and intended justice beneficiaries are essential to developing good decision-making mechanisms with respect to access to justice and technology. Dans le présent article, les auteurs examinent l’évolution du dialogue canadien sur l’accès à la justice, depuis l’analyse fondamentale de Macdonald en 2005 jusqu’aux récents rapports du Comité national d’action sur l’accès à la justice en matière civile et familiale (CNA). Ils se fondent sur la « vision élargie » de l’accès à la justice réclamée par le CNA pour évaluer de façon critique les exemples de technologies particulières utilisées ou proposées pour répondre à la crise de l’accès à la justice au Canada. Ce faisant, ils illustrent l’importance d’examiner de façon consciente les livrables et les bénéficiaires pour classer par ordre de priorité les technologies à déployer, pour déterminer comment la technologie devrait être déployée et pour évaluer le potentiel d’une technologie de faciliter l’accès à la justice. Les auteurs soutiennent que des comptes rendus nuancés des rapports entre les livrables en matière de justice, les mécanismes de livraison technologiques et les bénéficiaires prévus sont essentiels pour élaborer de bons mécanismes décisionnels en ce qui concerne l’accès à la justice et la technologie

Interferon-induced Transmembrane Protein 1 restricts replication of virus that enter cells via the plasma membrane.

The acute antiviral response is mediated by a family of interferon-stimulated genes (ISGs), providing cell-intrinsic immunity. Mutations in genes encoding these proteins are often associated with increased susceptibility to viral infections. One family of ISGs with antiviral function is the interferon-inducible transmembrane proteins (IFITMs), of which IFITM3 has been studied extensively. In contrast, IFITM1 has not been studied in detail. Since IFITM1 can localize to the plasma membrane, we investigated its function with a range of enveloped viruses thought to infect cells by fusion with the plasma membrane. Overexpression of IFITM1 prevented infection by a number of Paramyxoviridae and Pneumoviridae, including respiratory syncytial virus (RSV), mumps virus, and human metapneumovirus (HMPV). IFITM1 also restricted infection with an enveloped DNA virus that can enter via the plasma membrane, herpes simplex virus 1 (HSV-1). To test the importance of plasma membrane localization for IFITM1 function, we identified blocks of amino acids in the conserved intracellular loop (CIL) domain that altered the subcellular localization of the protein and reduced antiviral activity. By screening reported data sets, 12 rare nonsynonymous single nucleotide polymorphisms (SNPs) were identified in human IFITM1, some of which are in the CIL domain. Using an Ifitm1-/- mouse, we show that RSV infection was more severe, thereby extending the range of viruses restricted in vivo by IFITM proteins and suggesting overall that IFITM1 is broadly antiviral and that this antiviral function is associated with cell surface localization.IMPORTANCE Host susceptibility to viral infection is multifactorial, but early control of viruses not previously encountered is predominantly mediated by the interferon-stimulated gene (ISG) family. There are upwards of 300 of these genes, the majority of which do not have a clearly defined function or mechanism of action. The cellular location of these proteins may have an important effect on their function. One ISG located at the plasma membrane is interferon-inducible transmembrane protein 1 (IFITM1). Here we demonstrate that IFITM1 can inhibit infection with a range of viruses that enter via the plasma membrane. Mutant IFITM1 proteins that were unable to localize to the plasma membrane did not restrict viral infection. We also observed for the first time that IFITM1 plays a role in vivo, and Ifitm1-/- mice were more susceptible to viral lung infection. These data contribute to our understanding of how ISGs prevent viral infections