The 1996 research assessment exercise : the library and information management panel

Reports on the 1996 Research Assessment Exercise (RAE), the fourth such exercise aimed at providing funding councils of UK universities (including former polytechnics) with the necessary data to rate the quality of UK academic research for predetermined units of assessment in order to fund research selectively. Previous RAEs were conducted in 1986, 1989, and 1992 (for a report of the 1992 RAE see JOLIS 26 (3) Sep 94, 141-7 (LISA ref. 9409765)). Reports generally on the work of the Library and Information Management Panel in agreeing criteria specific to their assessment task, particularly the five principal modes of publication: research monographs; articles in scholarly periodicals; refereed conference papers; published research reports; and book chapters. Discusses the methodology used by the Panel, research submissions received and the overall results

Draft Genome Sequence of the Serratia rubidaea CIP 103234T Reference Strain, a Human-Opportunistic Pathogen.

We provide here the first genome sequence of a Serratia rubidaea isolate, a human-opportunistic pathogen. This reference sequence will permit a comparison of this species with others of the Serratia genus

Protein kinase A (PKA) phosphorylation of Shp2 inhibits its phosphatase activity and modulates ligand specificity.

Pathological cardiac hypertrophy (an increase in cardiac mass resulting from stress-induced cardiac myocyte growth) is a major factor underlying heart failure. Src homology 2 domain-containing phosphatase (Shp2) is critical for cardiac function as mutations resulting in loss of Shp2 catalytic activity are associated with congenital cardiac defects and hypertrophy. We have identified a novel mechanism of Shp2 inhibition that may promote cardiac hypertrophy. We demonstrate that Shp2 is a component of the A-kinase anchoring protein (AKAP)-Lbc complex. AKAP-Lbc facilitates protein kinase A (PKA) phosphorylation of Shp2, which inhibits Shp2 phosphatase activity. We have identified two key amino acids in Shp2 that are phosphorylated by PKA: Thr73 contributes a helix-cap to helix αB within the N-terminal SH2 domain of Shp2, whereas Ser189 occupies an equivalent position within the C-terminal SH2 domain. Utilizing double mutant PKA phospho-deficient (T73A/S189A) and phospho-mimetic (T73D/S189D) constructs, in vitro binding assays, and phosphatase activity assays, we demonstrate that phosphorylation of these residues disrupts Shp2 interaction with tyrosine-phosphorylated ligands and inhibits its protein tyrosine phosphatase activity. Overall, our data indicate that AKAP-Lbc integrates PKA and Shp2 signaling in the heart and that AKAP-Lbc-associated Shp2 activity is reduced in hypertrophic hearts in response to chronic β-adrenergic stimulation and PKA activation. Thus, while induction of cardiac hypertrophy is a multifaceted process, inhibition of Shp2 activity through AKAP-Lbc-anchored PKA is a previously unrecognized mechanism that may promote this compensatory response

A network approach for managing and processing big cancer data in clouds

Translational cancer research requires integrative analysis of multiple levels of big cancer data to identify and treat cancer. In order to address the issues that data is decentralised, growing and continually being updated, and the content living or archiving on different information sources partially overlaps creating redundancies as well as contradictions and inconsistencies, we develop a data network model and technology for constructing and managing big cancer data. To support our data network approach for data process and analysis, we employ a semantic content network approach and adopt the CELAR cloud platform. The prototype implementation shows that the CELAR cloud can satisfy the on-demanding needs of various data resources for management and process of big cancer data

Factorizations of Elements in Noncommutative Rings: A Survey

We survey results on factorizations of non zero-divisors into atoms (irreducible elements) in noncommutative rings. The point of view in this survey is motivated by the commutative theory of non-unique factorizations. Topics covered include unique factorization up to order and similarity, 2-firs, and modular LCM domains, as well as UFRs and UFDs in the sense of Chatters and Jordan and generalizations thereof. We recall arithmetical invariants for the study of non-unique factorizations, and give transfer results for arithmetical invariants in matrix rings, rings of triangular matrices, and classical maximal orders as well as classical hereditary orders in central simple algebras over global fields.Comment: 50 pages, comments welcom

Evaluaci?n del efecto analg?sico de la lidoca?na v?a intratesticular e intrafunicular en perros sometidos a orquiectomia electiva bajo un protocolo de anestesia disociativa

102 p. Recurso Electr?nicoOBJETIVOS: Evaluar el efecto analg?sico de la lidoca?na administrada v?a intratesticular e intrafunicular en perros sometidos a orquiectom?a electiva bajo un protocolo de anestesia disociativa. M?TODOS: Ensayo cl?nico prospectivo, doble ciego, aleatorizado. Animales: 31 caninos machos cl?nicamente sanos con edades comprendidas entre los 0,5 a 10 a?os y pesos entre los 6 a 30 kg. Los animales fueron incluidos al azar mediante un sistema de sobre cerrado dentro de uno de los siguientes grupos: Grupo 1 lidoca?na intratesticular (n=11); Grupo 2 control (n=10) y Grupo 3 lidoca?na intrafunicular (n=10). Los animales del grupo 1 y 3 recibieron 2 mg/kg de lidoca?na y los animales del grupo control recibieron soluci?n salina v?a intratesticular en un volumen equivalente al empleado de la lidoca?na para cada caso. Lo anterior como parte de un protocolo de anestesia balanceada que tambi?n incluy? acepromacina, meloxicam, tramadol y ketamina. Las variables cardiorrespiratorias: frecuencia cardiaca, frecuencia respiratoria y presi?n arterial media, as? como y los consumos intraoperatorios de ketamina y fentanilo (mg/kg) fueron evaluados mediante un ANOVA como valores porcentuales con respecto al tiempo basal pos inducci?n (5 minutos). RESULTADOS Y CONCLUSIONES: Los resultados del presente estudio permiten sugerir que la infiltraci?n de lidoca?na por cualquiera de las dos v?as evaluadas contribuye a disminuir el consumo de analg?sicos (p=0,02) y anest?sicos (p=0,001) intraoperatorios, disminuir significativamente la respuesta nociceptiva aut?noma del paciente durante los momentos m?s dolorosos del procedimiento (p=0,04) y reducir el n?mero de complicaciones intraoperatorias asociadas. Palabras clave: analgesia, anestesia local, castraci?n, lidoca?na, orquiectom?a, perro.OBJECTIVE: To evaluate the analgesic effect of lidocaine administered via intratesticular and intrafunicular in dogs undergoing elective orchiectomy under dissociative anesthesia protocol. METHODS: A prospective, double-blind, randomized. Animals: 31 male dogs clinically healthy aged 0.5 to 10 years old and weight between 6 to 30 kg. The animals were randomly included with sealed system within one of the following experimental groups: Group 1 intratesticular lidocaine (n = 11); Group 2 Control (n = 10) and Group 3 intrafunicular lidocaine (n = 10). The animals in group 1 and 3 received 2 mg/kg of lidocaine and control animals received saline via intratesticular an equivalent employee of lidocaine for each volume. This as part of a balanced anesthesia protocol also included acepromazine, meloxicam, tramadol and ketamine. Cardiorespiratory variables: heart rate, respiratory rate and blood pressure as well as intraoperative and consumption of ketamine and fentanyl (mg / kg) were evaluated by ANOVA as percentage values relative to baseline after induction time (5 minutes). RESULTS AND CONCLUSIONS: The results from this study suggest that infiltration of lidocaine evaluated either way helps to reduce the consumption of analgesics (p = 0.02) and anesthetic (p = 0.001) intraoperative significantly reduce the response nociceptive independent of the patient during the most painful moments of the procedure (p = 0.04) and reduce the number of intraoperative complications associated. Keywords: analgesia, local anesthesia, castration, lidocaine, orchiectomy, dog

Mixed-State Entanglement and Quantum Teleportation through Noisy Channels

The quantum teleportation with noisy EPR state is discussed. Using an optimal decomposition technique, we compute the concurrence, entanglement of formation and Groverian measure for various noisy EPR resources. It is shown analytically that all entanglement measures reduce to zero when $\bar{F} \leq 2/3$, where $\bar{F}$ is an average fidelity between Alice and Bob. This fact indicates that the entanglement is a genuine physical resource for the teleportation process. This fact gives valuable clues on the optimal decomposition for higher-qubit mixed states. As an example, the optimal decompositions for the three-qubit mixed states are discussed by adopting a teleportation with W-stateComment: 18 pages, 4 figure

The enzymes LSD1 and Set1A cooperate with the viral protein HBx to establish an active hepatitis B viral chromatin state

Indexación: Web of ScienceWith about 350 million people chronically infected around the world hepatitis B is a major health problem. Template for progeny HBV synthesis is the viral genome, organized as a minichromosome (cccDNA) inside the hepatocyte nucleus. How viral cccDNA gene expression is regulated by its chromatin structure; more importantly, how the modulation of this structure impacts on viral gene expression remains elusive. Here, we found that the enzyme SetDB1 contributes to setting up a repressed cccDNA chromatin state. This repressive state is activated by the histone lysine demethylase-1 (LSD1). Consistently, inhibiting or reducing LSD1 levels led to repression of viral gene expression. This correlates with the transcriptionally repressive mark H3K9 methylation and reduction on the activating marks H3 acetylation and H3K4 methylation on viral promoters. Investigating the importance of viral proteins we found that LSD1 recruitment to viral promoters was dependent on the viral transactivator protein HBx. Moreover, the histone methyltransferase Set1A and HBx are simultaneously bound to the core promoter, and Set1A expression correlates with cccDNA H3K4 methylation. Our results shed light on the mechanisms of HBV regulation mediated by the cccDNA chromatin structure, offering new therapeutic targets to develop drugs for the treatment of chronically infected HBV patients.http://www.nature.com/articles/srep2590

Auto-tail dependence coefficients for stationary solutions of linear stochastic recurrence equations and for GARCH(1,1)

We examine the auto-dependence structure of strictly stationary solutions of linear stochastic recurrence equations and of strictly stationary GARCH(1, 1) processes from the point of view of ordinary and generalized tail dependence coefficients. Since such processes can easily be of infinite variance, a substitute for the usual auto-correlation function is needed