Objective automatic assessment of rehabilitative speech treatment in Parkinson's disease

Vocal performance degradation is a common symptom for the vast majority of Parkinson's disease (PD) subjects, who typically follow personalized one-to-one periodic rehabilitation meetings with speech experts over a long-term period. Recently, a novel computer program called Lee Silverman voice treatment (LSVT) Companion was developed to allow PD subjects to independently progress through a rehabilitative treatment session. This study is part of the assessment of the LSVT Companion, aiming to investigate the potential of using sustained vowel phonations towards objectively and automatically replicating the speech experts' assessments of PD subjects' voices as “acceptable” (a clinician would allow persisting during in-person rehabilitation treatment) or “unacceptable” (a clinician would not allow persisting during in-person rehabilitation treatment). We characterize each of the 156 sustained vowel /a/ phonations with 309 dysphonia measures, select a parsimonious subset using a robust feature selection algorithm, and automatically distinguish the two cohorts (acceptable versus unacceptable) with about 90% overall accuracy. Moreover, we illustrate the potential of the proposed methodology as a probabilistic decision support tool to speech experts to assess a phonation as “acceptable” or “unacceptable.” We envisage the findings of this study being a first step towards improving the effectiveness of an automated rehabilitative speech assessment tool

Factors associated with reporting of sexual assault among college and non-college women

Purpose The purpose of this paper is to examine factors impacting college and non-college women reporting sexual assault to police. The goal is to increase knowledge regarding differences in the rates of reporting and reasons for reporting across these two groups. Design/methodology/approach Participants were drawn from a national telephone survey of US women and a sample of US college women. Bivariate and multivariate analyses were conducted to determine factors influencing the reporting of sexual assault to police. Findings Non-college women were more likely than college women to report to police. Women who perceived their victimization as rape were much more likely to report to the police and women who had contact with a helping agency were also much more likely to report their assault. Contacting a helping agency is more relevant to non-college women’s reporting to police, while considering the assault a rape is more important for college women. Practical implications The results suggest that significant work is needed to encourage women in college to view sexual assaults as worthy of reporting. Boosting victim awareness and access to services is paramount. Providing education and empowerment to student victims to inform their perceptions about the definition of rape is vital, as women perceiving sexual assault as rape are more likely to report the incident. Originality/value The research significantly adds to the literature indicating differences in rates of reporting and the factors that impact reporting uniquely for college vs non-college women

A Wellness Approach to Investigating Student Veterans’ Career Goals

A qualitative methodology was utilized to assess the wellness factors student Veterans (N = 10) perceived as influential to their decision to separate from the military and choice of intended career path. Participants included prior enlisted student Veterans pursuing undergraduate degrees at a mid-sized Midwestern university. Interview transcripts were coded according to the Indivisible Self Model of Wellness (IS-Wel; Myers & Sweeney, 2004) and analyzed phenomenologically. Participants referenced Control and Self-Worth as motivators for separation from military service; Work and Thinking were the main themes regarding choice of future profession. Additional themes emerged in reference to how Veterans’ priorities changed during their time in service. The IS-Wel serves as an innovative approach for facilitating student Veteran career development

Clinical characteristics, etiology and antimicrobial susceptibility among overweight and obese individuals with diarrhea: observed at a large diarrheal disease hospital, Bangladesh

Background:The present study aimed to determine the clinical characteristics and etiology of overweight and obese (OO) individuals with diarrhea attending an urban Dhaka Hospital, International Centre for Diarrheal Disease Research (icddr,b), Bangladesh.Methods:Total of 508 under-5 children, 96 individuals of 5-19 years and 1331 of >19 years were identified as OO from the Diarrheal Disease Surveillance System (DDSS) between 1993-2011. Two comparison groups such as well-nourished and malnourished individuals from respective age stratums were selected.Results:Isolation rate of rotavirus was higher among OO under-5 children compared to malnourished group (46% vs. 28%). Rotavirus infection among OO individuals aged 5-19 years (9% vs. 3%) (9% vs. 3%) and >19 years (6% vs. 4%) (6% vs. 3%) was higher compared to well-nourished and malnourished children. Conversely, Vibrio cholerae was lower among all OO age groups compared to well-nourished and malnourished ones. Shigella (4% vs. 6%) (4% vs. 8%), and Campylobacter (3% vs. 5%) (3% vs. 5%) were lower only among OO in >19 years individuals compared to their counterparts of the same age stratum. Salmonella was similarly isolated in all age strata and nutritional groups. In multinomial logistic regression among under-5 children, significant association was observed only with use of antimicrobials at home [OR-1.97] and duration of hospital stay [OR-0.68]. For individuals aged 5-19 years, use of antimicrobials at home (OR-1.83), some or severe dehydration (OR-3.12), having received intravenous saline (OR-0.46) and rotavirus diarrhea (OR-2.96) were found to be associated with OO respectively. Moreover, significant associations were also found for duration of diarrhea before coming to hospital (>24 hours) (OR-1.24), Shigella (OR-0.46), and Campylobacter (OR-0.58) among >19 years OO individuals along with other associated co-variates in 5-19 years group (all

Identifying Causative Microorganisms in Left Ventricular Assist Device Infections as a Guide for Developing Bacteriophage Therapy

BACKGROUND: As more left ventricular-assist devices (LVADs) are implanted, multidrug-resistant LVAD infections are becoming increasingly common, partly due to bacterial biofilm production. To aid in developing bacteriophage therapy for LVAD infections, we have identified the most common bacterial pathogens that cause LVAD driveline infections (DLIs) in our heart transplant referral center. MATERIALS AND METHODS: We studied a retrospective cohort of patients who received LVADs from November 2003 to August 2017 to identify the common causative organisms of LVAD infection. We also studied a prospective cohort of patients diagnosed with DLIs from October 2018 to May 2019 to collect bacterial strains from DLIs for developing bacteriophages to lyse causative pathogens. LVAD infections were classified as DLI, bacteremia, and pump/device infections in the retrospective cohort. RESULTS: In the retrospective cohort of 582 patients, 186 (32.0%) developed an LVAD infection, with 372 microbial isolates identified. In the prospective cohort, 96 bacterial strains were isolated from 54 DLIs. The microorganisms causing DLIs were similar in the two cohorts; the most common isolate was Staphylococcus aureus. We identified 6 prospective S. aureus strains capable of biofilm formation. We developed 3 bacteriophages that were able to lyse 5 of 6 of the biofilm-forming S. aureus strains. CONCLUSIONS: Similar pathogens caused LVAD DLIs in our retrospective and prospective cohorts, indicating our bacterial strain bank will be representative of future DLIs. Our banked bacterial strains will be useful in developing phage cocktails that can lyse ≥80% of the bacteria causing LVAD infections at our institution

Corrigendum: Development of Phage Cocktails To Treat E. coli Catheter-Associated Urinary Tract Infection and Associated Biofilms

In the published article “Kenneth L. Muldrew” was not included as an author. The corrected Author Contributions Statement appears below. BS, EH, and SG performed the experiments and analyzed the data. JC performed the bioinformatic analysis of depolymerase enzymes. BT, FS, KM, and CH-M arranged for the collection of clinical isolates and corresponding antibiotic sensitivity data. RR and HK contributed to the design of the study and edited the manuscript. BS designed the study and wrote the manuscript. BT and AM contributed to the design and overall major goals of the study and edited the manuscript. All authors contributed to the article and approved the submitted version. The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way. The original article has been updated

Understanding Uncertainty in Market-Mediated Responses to US Oilseed Biodiesel Demand: Sensitivity of ILUC Emission Estimates to GLOBIOM Parametric Uncertainty

The life cycle greenhouse gas (GHG) emissions of biofuels depend on uncertain estimates of induced land use change (ILUC) and subsequent emissions from carbon stock changes. Demand for oilseed-based biofuels is associated with particularly complex market and supply chain dynamics, which must be considered. Using the global partial equilibrium model GLOBIOM, this study explores the uncertainty in market-mediated impacts and ILUC-related emissions from increasing demand for soybean biodiesel in the United States in the period 2020–2050. A one-at-a-time (OAT) analysis and a Monte Carlo (MC) analysis are performed to assess the sensitivity of modeled ILUC-GHG emissions intensities (gCO2e/MJ) to varying key economic and biophysical model parameters. Additionally, the influence of the approach on the simulation of future ILUC effects is explored using two alternative ILUC-GHG metrics: a comparative-static approach for 2030 and a recursive-dynamic approach using model outputs through 2050. We find that projected ILUC-GHG values largely vary based on which vegetable oils replace diverted soybean oil, market responses to coproducts, and the carbon content of land converted for agricultural use. These are all, in turn, subject to decision uncertainty through the choice of the modeling approach and the time horizon considered for each ILUC-GHG metric. Given the longer simulation period, ILUC-GHG emission uncertainty ranges increase under the recursive-dynamic approach (42.4 ± 25.9 gCO2e/MJ) compared to the comparative-static approach (40.8 ± 20.5 gCO2e/MJ). The combination of MC analysis with other techniques such as Bayesian Additive Regression Trees (BART) is powerful for understanding model behavior and clarifying the sensitivity of market responses, ILUC, and associated GHG emissions to specific model parameters when simulated with global economic models. The BART reveals that biophysical parameters generate more linear ILUC-GHG responses to changes in assumed parameter values while changes in economic parameters lead to more nonlinear ILUC-GHG results as multiple effects at the interplay of food, feed, and fuel uses overlap. The choice of the recursive-dynamic metric allows capturing the longer-term evolution of ILUC while generating additional uncertainties derived from the baseline definition

Auditory Feedback Control of Vocal Pitch during Sustained Vocalization: A Cross-Sectional Study of Adult Aging

Background: Auditory feedback has been demonstrated to play an important role in the control of voice fundamental frequency (F0), but the mechanisms underlying the processing of auditory feedback remain poorly understood. It has been well documented that young adults can use auditory feedback to stabilize their voice F0 by making compensatory responses to perturbations they hear in their vocal pitch feedback. However, little is known about the effects of aging on the processing of audio-vocal feedback during vocalization. Methodology/Principal Findings: In the present study, we recruited adults who were between 19 and 75 years of age and divided them into five age groups. Using a pitch-shift paradigm, the pitch of their vocal feedback was unexpectedly shifted 650 or 6100 cents during sustained vocalization of the vowel sound/u/. Compensatory vocal F0 response magnitudes and latencies to pitch feedback perturbations were examined. A significant effect of age was found such that response magnitudes increased with increasing age until maximal values were reached for adults 51–60 years of age and then decreased for adults 61–75 years of age. Adults 51–60 years of age were also more sensitive to the direction and magnitude of the pitch feedback perturbations compared to younger adults. Conclusion: These findings demonstrate that the pitch-shift reflex systematically changes across the adult lifespan. Understanding aging-related changes to the role of auditory feedback is critically important for our theoretica