Evidentialist Foundationalist Argumentation in Multi-Agent Systems

This dissertation focuses on the explicit grounding of reasoning in evidence directly sensed from the physical world. Based on evidence from human problem solving and successes, this is a straightforward basis for reasoning: to solve problems in the physical world, the information required for solving them must also come from the physical world. What is less straightforward is how to structure the path from evidence to conclusions. Many approaches have been applied to evidence-based reasoning, including probabilistic graphical models and Dempster-Shafer theory. However, with some exceptions, these traditional approaches are often employed to establish confidence in a single binary conclusion, like whether or not there is a blizzard, rather than developing complex groups of scalar conclusions, like where a blizzard's center is, what area it covers, how strong it is, and what components it has. To form conclusions of the latter kind, we employ and further develop the approach of Computational Argumentation. Specifically, this dissertation develops a novel approach to evidence-based argumentation called Evidentialist Foundationalist Argumentation (EFA). The method is a formal instantiation of the well-established Argumentation Service Platform with Integrated Components (ASPIC) framework. There are two primary approaches to Computational Argumentation. One approach is structured argumentation where arguments are structured with premises, inference rules, conclusions, and arguments based on the conclusions of other arguments, creating a tree-like structure. The other approach is abstract argumentation where arguments interact at a higher level through an attack relation. ASPIC unifies the two approaches. EFA instantiates ASPIC specifically for the purpose of reasoning about physical evidence in the form of sensor data. By restricting ASPIC specifically to sensor data, special philosophical and computational advantages are gained. Specifically, all premises in the system (evidence) can be treated as firmly grounded axioms and all arguments' conclusions can be numerically calculated directly from their premises. EFA could be used as the basis for well-justified, transparent reasoning in many domains including engineering, law, business, medicine, politics, and education. To test its utility as a basis for Computational Argumentation, we apply EFA to a Multi-Agent System working in the problem domain of Sensor Webs on the specific problem of Decentralized Sensor Fusion. In the Multi-Agent Decentralized Sensor Fusion problem, groups of individual agents are assigned to sensor stations that are distributed across a geographical area, forming a Sensor Web. The goal of the system is to strategically share sensor readings between agents to increase the accuracy of each individual agent's model of the geophysical sensing situation. For example, if there is a severe storm, a goal may be for each agent to have an accurate model of the storm's heading, severity, and focal points of activity. Also, since the agents are controlling a Sensor Web, another goal is to use communication judiciously so as to use power efficiently. To meet these goals, we design a Multi-Agent System called Investigative Argumentation-based Negotiating Agents (IANA). Agents in IANA use EFA as the basis for establishing arguments to model geophysical situations. Upon gathering evidence in the form of sensor readings, the agents form evidence-based arguments using EFA. The agents systematically compare the conclusions of their arguments to other agents. If the agents sufficiently agree on the geophysical situation, they end communication. If they disagree, then they share the evidence for their conclusions, consuming communication resources with the goal of increasing accuracy. They execute this interaction using a Share on Disagreement (SoD) protocol. IANA is evaluated against two other Multi-Agent System approaches on the basis of accuracy and communication costs, using historical real-world weather data. The first approach is all-to-all communication, called the Complete Data Sharing (CDS) approach. In this system, agents share all observations, maximizing accuracy but at a high communication cost. The second approach is based on Kalman Filtering of conclusions and is called the Conclusion Negotiation Only (CNO) approach. In this system, agents do not share any observations, and instead try to infer the geophysical state based only on each other's conclusions. This approach saves communication costs but sacrifices accuracy. The results of these experiments have been statistically analyzed using omega-squared effect sizes produced by ANOVA with p-values < 0.05. The IANA system was found to outperform the CDS system for message cost with high effect sizes. The CDS system outperformed the IANA system for accuracy with only small effect sizes. The IANA system was found to outperform the CNO system for accuracy with mostly high and medium effect sizes. The CNO system outperformed the IANA system for message costs with only small effect sizes. Given these results, the IANA system is preferable for most of the testing scenarios for the problem solved in this dissertation

The Trial of General Tomoyuki Yamashita: A Case Study in Command Responsibility

The case of General \u27Tomoyuki Yamashita, the subject of this thesis, established a precedent in international law, at least so far as the United States respected that law, Its successful prosecution prepared the way for the prosecution of numerous, subsequent war crimes cases, upon a standard of liability developed and approved by the United States in Yamashita, and without regard for the attenuated procedural protections granted in American civil courts. General Mac-Arthur played an important part in Yamashita’s trial, and this essay shall also discuss the extent of his interest and involvement in the case

B Cells Regulate Neutrophilia during Mycobacterium tuberculosis Infection and BCG Vaccination by Modulating the Interleukin-17 Response

We have previously demonstrated that B cells can shape the immune response to Mycobacterium tuberculosis, including the level of neutrophil infiltration and granulomatous inflammation at the site of infection. The present study examined the mechanisms by which B cells regulate the host neutrophilic response upon exposure to mycobacteria and how neutrophilia may influence vaccine efficacy. To address these questions, a murine aerosol infection tuberculosis (TB) model and an intradermal (ID) ear BCG immunization mouse model, involving both the μMT strain and B cell-depleted C57BL/6 mice, were used. IL (interleukin)-17 neutralization and neutrophil depletion experiments using these systems provide evidence that B cells can regulate neutrophilia by modulating the IL-17 response during M. tuberculosis infection and BCG immunization. Exuberant neutrophilia at the site of immunization in B cell-deficient mice adversely affects dendritic cell (DC) migration to the draining lymph nodes and attenuates the development of the vaccine-induced Th1 response. The results suggest that B cells are required for the development of optimal protective anti-TB immunity upon BCG vaccination by regulating the IL-17/neutrophilic response. Administration of sera derived from M. tuberculosis-infected C57BL/6 wild-type mice reverses the lung neutrophilia phenotype in tuberculous μMT mice. Together, these observations provide insight into the mechanisms by which B cells and humoral immunity modulate vaccine-induced Th1 response and regulate neutrophila during M. tuberculosis infection and BCG immunization. © 2013 Kozakiewicz et al

Hostility, Race, and Glucose Metabolism in Nondiabetic Individuals

OBJECTIVE— The present study was designed to determine whether hostility is differentially related to measures of glucose metabolism in African-Americans and Caucasians. RESEARCH DESIGN AND METHODS— The relationship of hostility, as measured by a subset of the Cook-Medley hostility scale (CMHOST) inventory items, to various parameters of glucose metabolism were examined in a young, healthy sample of male and female African-American and Caucasian volunteers. Fasting blood samples were collected during an inpatient admission, at which time the CMHOST was also administered. RESULTS— In the entire sample, the CMHOST was found to be significantly correlated with fasting glucose and insulin sensitivity, as measured by the homeostatic model assessment (HOMA). However, the relationship of hostility to these parameters of glucose metabolism was different in African-American and Caucasian subjects. Hostility was significantly related to fasting glucose in African-Americans and to insulin sensitivity and fasting insulin in Caucasian subjects. The relationship of hostility to insulin sensitivity and fasting insulin was partially dependent on BMI in Caucasians, but the relationship of hostility to fasting glucose was unrelated to BMI in African-Americans. CONCLUSIONS— Our data suggest that the relationship of hostility to measures of glucose metabolism is mediated differently in these two ethnic groups. Therefore, hostility seems to be part of a constellation of risk-related behaviors related to BMI in Caucasians but independently related to fasting glucose in African-Americans

Biodiversity Loss and the Taxonomic Bottleneck: Emerging Biodiversity Science

Human domination of the Earth has resulted in dramatic changes to global and local patterns of biodiversity. Biodiversity is critical to human sustainability because it drives the ecosystem services that provide the core of our life-support system. As we, the human species, are the primary factor leading to the decline in biodiversity, we need detailed information about the biodiversity and species composition of specific locations in order to understand how different species contribute to ecosystem services and how humans can sustainably conserve and manage biodiversity. Taxonomy and ecology, two fundamental sciences that generate the knowledge about biodiversity, are associated with a number of limitations that prevent them from providing the information needed to fully understand the relevance of biodiversity in its entirety for human sustainability: (1) biodiversity conservation strategies that tend to be overly focused on research and policy on a global scale with little impact on local biodiversity; (2) the small knowledge base of extant global biodiversity; (3) a lack of much-needed site-specific data on the species composition of communities in human-dominated landscapes, which hinders ecosystem management and biodiversity conservation; (4) biodiversity studies with a lack of taxonomic precision; (5) a lack of taxonomic expertise and trained taxonomists; (6) a taxonomic bottleneck in biodiversity inventory and assessment; and (7) neglect of taxonomic resources and a lack of taxonomic service infrastructure for biodiversity science. These limitations are directly related to contemporary trends in research, conservation strategies, environmental stewardship, environmental education, sustainable development, and local site-specific conservation. Today’s biological knowledge is built on the known global biodiversity, which represents barely 20% of what is currently extant (commonly accepted estimate of 10 million species) on planet Earth. Much remains unexplored and unknown, particularly in hotspots regions of Africa, South Eastern Asia, and South and Central America, including many developing or underdeveloped countries, where localized biodiversity is scarcely studied or described. ‘‘Backyard biodiversity’’, defined as local biodiversity near human habitation, refers to the natural resources and capital for ecosystem services at the grassroots level, which urgently needs to be explored, documented, and conserved as it is the backbone of sustainable economic development in these countries. Beginning with early identification and documentation of local flora and fauna, taxonomy has documented global biodiversity and natural history based on the collection of ‘‘backyard biodiversity’’ specimens worldwide. However, this branch of science suffered a continuous decline in the latter half of the twentieth century, and has now reached a point of potential demise. At present there are very few professional taxonomists and trained local parataxonomists worldwide, while the need for, and demands on, taxonomic services by conservation and resource management communities are rapidly increasing. Systematic collections, the material basis of biodiversity information, have been neglected and abandoned, particularly at institutions of higher learning. Considering the rapid increase in the human population and urbanization, human sustainability requires new conceptual and practical approaches to refocusing and energizing the study of the biodiversity that is the core of natural resources for sustainable development and biotic capital for sustaining our life-support system. In this paper we aim to document and extrapolate the essence of biodiversity, discuss the state and nature of taxonomic demise, the trends of recent biodiversity studies, and suggest reasonable approaches to a biodiversity science to facilitate the expansion of global biodiversity knowledge and to create useful data on backyard biodiversity worldwide towards human sustainability

Measurements of the branching fractions of B+→ppK+ decays

The branching fractions of the decay B+ → pp̄K+ for different intermediate states are measured using data, corresponding to an integrated luminosity of 1.0 fb-1, collected by the LHCb experiment. The total branching fraction, its charmless component Mpp̄ < 2.85 GeV/c2 and the branching fractions via the resonant cc̄ states η c(1S) and ψ(2S) relative to the decay via a J/ψ intermediate state are [Equation not available: see fulltext.] Upper limits on the B + branching fractions into the η c(2S) meson and into the charmonium-like states X(3872) and X(3915) are also obtained

Study of B0(s)→K0Sh+h′− decays with first observation of B0s→K0SK±π∓ and B0s→K0Sπ+π−

A search for charmless three-body decays of B 0 and B0s mesons with a K0S meson in the final state is performed using the pp collision data, corresponding to an integrated luminosity of 1.0 fb−1, collected at a centre-of-mass energy of 7 TeV recorded by the LHCb experiment. Branching fractions of the B0(s)→K0Sh+h′− decay modes (h (′) = π, K), relative to the well measured B0→K0Sπ+π− decay, are obtained. First observation of the decay modes B0s→K0SK±π∓ and B0s→K0Sπ+π− and confirmation of the decay B0→K0SK±π∓ are reported. The following relative branching fraction measurements or limits are obtained B(B0→K0SK±π∓)B(B0→K0Sπ+π−)=0.128±0.017(stat.)±0.009(syst.), B(B0→K0SK+K−)B(B0→K0Sπ+π−)=0.385±0.031(stat.)±0.023(syst.), B(B0s→K0Sπ+π−)B(B0→K0Sπ+π−)=0.29±0.06(stat.)±0.03(syst.)±0.02(fs/fd), B(B0s→K0SK±π∓)B(B0→K0Sπ+π−)=1.48±0.12(stat.)±0.08(syst.)±0.12(fs/fd)B(B0s→K0SK+K−)B(B0→K0Sπ+π−)∈[0.004;0.068]at90%CL

Observation of the decay Bc→J/ψK+K−π+B_c \rightarrow J/\psi K^+ K^- \pi^+

The decay $B_c\rightarrow J/\psi K^+ K^- \pi^+$ is observed for the first time, using proton-proton collisions collected with the LHCb detector corresponding to an integrated luminosity of 3fb$^{-1}$. A signal yield of $78\pm14$ decays is reported with a significance of 6.2 standard deviations. The ratio of the branching fraction of \B_c \rightarrow J/\psi K^+ K^- \pi^+ decays to that of $B_c \rightarrow J/\psi \pi^+$ decays is measured to be $0.53\pm 0.10\pm0.05$, where the first uncertainty is statistical and the second is systematic.Comment: 18 pages, 2 figure

Observation of the decay B+c→Bºsπ+

The result of a search for the decay B+c→Bºsπ+ is presented, using the Bºs→Ds-π+ and Bºs→J/ψϕ channels. The analysis is based on a data sample of pp collisions collected with the LHCb detector, corresponding to an integrated luminosity of 1  fb-1 taken at a center-of-mass energy of 7 TeV, and 2  fb-1 taken at 8 TeV. The decay B+c→Bºsπ+ is observed with significance in excess of 5 standard deviations independently in both decay channels. The measured product of the ratio of cross sections and branching fraction is [σ(Bc+)/σ(Bºs)]×B(Bc+→Bºsπ+)=[2.37±0.31 (stat)±0.11 (syst)-0.13+0.17(τBc+)]×10-3, in the pseudorapidity range 2<η(B)<5, where the first uncertainty is statistical, the second is systematic, and the third is due to the uncertainty on the Bc+ lifetime. This is the first observation of a B meson decaying to another B meson via the weak interaction