Giant Angiolymphoid Hyperplasia with Eosinophilia on the Chest

Angiolymphoid hyperplasia with eosinophilia is a rare vascular proliferation characterized by single or multiple purplish, brownish papules and subcutaneous nodules, sometimes associated with pain or pruritus. This rare benign process occurs with a female predominance. Approximately 85% of the lesions occur in the skin of the head and neck; most of them are around the ear or on the forehead or scalp. Whether angiolymphoid hyperplasia with eosinophilia represents a benign neoplasm or an unusual reaction to varied stimuli, including trauma, the etiology remains unclear. Histopathologically, the lesions consist of a proliferation of blood vessels of variable size lined by large epithelioid endothelial cells and a variable inflammatory infiltrate of lymphocytes and eosinophils, sometimes with lymphoid follicle formation. The lesion is benign but may be persistent and is difficult to eradicate. We report on a case of a 58-year-old Caucasian man who presented a purplish pink dome-shaped tumor of size up to 8 cm in diameter located on the chest. We emphasize this case considering the unusual dimensions of the lesion (8 cm diameter) and the atypical location on the chest

Pseudo-Kaposi's Sarcoma Because of Suction-Socket Lower Limb Prosthesis

Pseudo-Kaposi sarcoma is a benign reactive vascular proliferation mainly involving the lower legs, which can be related to acquired chronic venous insufficiency or congenital arteriovenous malformations. In its most common presentation, acroangiodermatitis is seen in patients with chronic venous insufficiency of the lower limbs as an exaggeration of the stasis dermatitis. However, rare reports of acroangiodermatitis include descriptions in amputees (especially in those with poorly fitting suction-type devices), in patients undergoing hemodialysis (with lesions developing distally to arteriovenous shunts) and in patients with paralyzed legs. We report on a 28 year-old-male who presented pseudo-Kaposi's sarcoma in an amputation stump because of suction-socket lower limb prosthesis

Mineralogy and geochemical features of the recent sediments in the Odiel river (Huelva)

[Resumen] Los componentes minera16gicos fundamentales de los sedimentos actuales del río Odiel son: cuarzo, feldespatos y filosilicatos. La asociación illita-clorita-caolinita refleja el carácter esencialmente detrítico heredado de los minerales de la arcilla. Por otra parte, la asociación de minerales pesados muestra la influencia de diferentes áreas fuentes. El Odiel está extremadamente contaminado por metales pesados. La proximidad de importantes centros mineros de la Faja Pirítica tiene una gran incidencia sobre la concentración y distribución de Fe, Cu, Pb, Zn y Mn. Los sedimentos del estuario presentan algunas diferencias mineralógicas y geoquímicas importantes con respecto a los sedimentos típicamente fluviales.[Abstract] The mineralogical composition and the heavy metals content of recent sediments in the Odiel river have been investigated. Quanz, feldspar an phyllosilicates are the major constituents of the bulk sample. The illite-chlorite-kaolinite assemblage shows the inherited detrital character of the clay minerals. On the other hand, the heavy mineral associations indicate source areas. The river is very polluted by heavy metals. The proximity of important mining centres has a strong influence on the concentration and distribucion of Fe, Cu, Pb, Zn and Mn. The estuarine sediments studied have sorne mineralogical and geochemical features which are different from that of typical river sediments

Ionized gas at the edge of the Central Molecular Zone

To determine the properties of the ionized gas at the edge of the CMZ near Sgr E we observed a small portion of the edge of the CMZ near Sgr E with spectrally resolved [C II] 158 micron and [N II] 205 micron fine structure lines at six positions with the GREAT instrument on SOFIA and in [C II] using Herschel HIFI on-the-fly strip maps. We use the [N II] spectra along with a radiative transfer model to calculate the electron density of the gas and the [C II] maps to illuminate the morphology of the ionized gas and model the column density of CO-dark H2. We detect two [C II] and [N II] velocity components, one along the line of sight to a CO molecular cloud at -207 km/s associated with Sgr E and the other at -174 km/s outside the edge of another CO cloud. From the [N II] emission we find that the average electron density is in the range of about 5 to 25 cm{-3} for these features. This electron density is much higher than that of the warm ionized medium in the disk. The column density of the CO-dark H$_2$ layer in the -207 km/s cloud is about 1-2X10{21} cm{-2} in agreement with theoretical models. The CMZ extends further out in Galactic radius by 7 to 14 pc in ionized gas than it does in molecular gas traced by CO. The edge of the CMZ likely contains dense hot ionized gas surrounding the neutral molecular material. The high fractional abundance of N+ and high electron density require an intense EUV field with a photon flux of order 1e6 to 1e7 photons cm{-2} s{-1}, and/or efficient proton charge exchange with nitrogen, at temperatures of order 1e4 K, and/or a large flux of X-rays. Sgr E is a region of massive star formation which are a potential sources of the EUV radiation that can ionize the gas. In addition X-ray sources and the diffuse X-ray emission in the CMZ are candidates for ionizing nitrogen.Comment: 12 pages, 9 figure

L1599B: Cloud Envelope and C+ Emission in a Region of Moderately Enhanced Radiation Field

We study the effects of an asymmetric radiation field on the properties of a molecular cloud envelope. We employ observations of carbon monoxide (12CO and 13CO), atomic carbon, ionized carbon, and atomic hydrogen to analyze the chemical and physical properties of the core and envelope of L1599B, a molecular cloud forming a portion of the ring at approximately 27 pc from the star Lambda Ori. The O III star provides an asymmetric radiation field that produces a moderate enhancement of the external radiation field. Observations of the [CII] fine structure line with the GREAT instrument on SOFIA indicate a significant enhanced emission on the side of the cloud facing the star, while the [Ci], 12CO and 13CO J = 1-0 and 2-1, and 12CO J = 3-2 data from the PMO and APEX telescopes suggest a relatively typical cloud interior. The atomic, ionic, and molecular line centroid velocities track each other very closely, and indicate that the cloud may be undergoing differential radial motion. The HI data from the Arecibo GALFA survey and the SOFIA/GREAT [CII] data do not suggest any systematic motion of the halo gas, relative to the dense central portion of the cloud traced by 12CO and 13CO.Comment: 9 Figure

Assessment of the microbiological quality of groundwater in three regions of the Valencian community (Spain)

Urban groundwater development was traditionally constrained by concerns about its quality. This study was conducted in the regions of La Ribera Alta and Ribera Baja and La Plana de Requena-Utiel of the Valencian Community (Valencia, Spain) where population density, demand for drinking water and agricultural activities are high. Groundwater bodies (GWBs) are regarded as management areas within each territory, and were used to establish protection policies. This study analyzed eleven GWBs. We used two databases with microbiological measurements from 154 wells over a 7-year period (2004-2011), risk factors and groundwater information. Wells were grouped according to frequency of microbiological contamination using E. coli measurements, category <1, or wells with low-frequency microbiological contamination and high-frequency wells or category 1-100, according to World Health Organization (WHO) quality criteria of drinking water. Of all wells, 18.12% showed high-frequency microbiological contamination with a majority distribution in the Ribera Alta region (26.98%, p < 0.001). No significant differences were found between the two risk categories for flow, static level, well depth and distance from population centres. This paper reveals that the vulnerability classes established by the Geological and Mining Institute of Spain (IGME) do not match the microbiological results, and that only eight wells with high-frequency contamination coincide with the high vulnerability areas

The nucleotidohydrolases DCTPP1 and dUTPase are involved in the cellular response to decitabine

Decitabine (5-aza-2acute;-deoxycytidine, aza-dCyd) is an anticancer drug used clinically for the treatment of myelodysplastic syndromes and acute myeloid leukemia that can act as a DNA-demethylating or genotoxic agent in a dose-dependent manner. On the other hand, DCTPP1 and dUTPase are two "house-cleaning" nucleotidohydrolases involved in the elimination of non-canonical nucleotides. Here we show that exposure of HeLa cells to decitabine up-regulates the expression of several pyrimidine metabolic enzymes including DCTPP1, dUTPase, dCMP deaminase and thymidylate synthase thus suggesting their contribution to the cellular response to this anticancer nucleoside. We present several lines of evidence supporting that, in addition to the formation of aza-dCTP, an alternative cytotoxic mechanism for decitabine may involve the formation of aza-dUMP, a potential thymidylate synthase inhibitor. Indeed, dUTPase or DCTPP1 down-regulation enhanced the cytotoxic effect of aza-dCyd producing an accumulation of nucleoside triphosphates containing uracil as well as uracil misincorporation and double-strand breaks in genomic DNA. Moreover, DCTPP1 hydrolyzes the triphosphate form of decitabine with similar kinetic efficiency than its natural substrate dCTP and prevents decitabine-induced global DNA demethylation. The data suggest that the nucleotidohydrolases DCTPP1 and dUTPase are factors involved in the mode of action of decitabine with potential value as enzymatic targets to improve decitabine-based chemotherapy

Comparing [C II], H I, and CO dynamics of nearby galaxies

The HI and CO components of the interstellar medium (ISM) are usually used to derive the dynamical mass M-dyn of nearby galaxies. Both components become too faint to be used as a tracer in observations of high-redshift galaxies. In those cases, the 158 mu m line of atomic carbon ([CII]) may be the only way to derive M-dyn. As the distribution and kinematics of the ISM tracer affects the determination of M-dyn, it is important to quantify the relative distributions of HI, CO, and [CII]. HI and CO are well-characterized observationally, however, for [CII] only very few measurements exist. Here we compare observations of CO, HI, and [CII] emission of a sample of nearby galaxies, drawn from the HERACLES, THINGS, and KINGFISH surveys. We find that within R-25, the average [CII] exponential radial profile is slightly shallower than that of the CO, but much steeper than the HI distribution. This is also reflected in the integrated spectrum ("global profile"), where the [CII] spectrum looks more like that of the CO than that of the HI. For one galaxy, a spectrally resolved comparison of integrated spectra was possible; other comparisons were limited by the intrinsic line-widths of the galaxies and the coarse velocity resolution of the [CII] data. Using high-spectral-resolution SOFIA [CII] data of a number of star forming regions in two nearby galaxies, we find that their [CII] linewidths agree better with those of the CO than the HI. As the radial extent of a given ISM tracer is a key input in deriving M-dyn from spatially unresolved data, we conclude that the relevant length-scale to use in determining M-dyn based on [CII] data, is that of the well-characterized CO distribution. This length scale is similar to that of the optical disk

Comparing [CII], HI, and CO dynamics of nearby galaxies

The HI and CO components of the interstellar medium (ISM) are usually used to derive the dynamical mass M_dyn of nearby galaxies. Both components become too faint to be used as a tracer in observations of high-redshift galaxies. In those cases, the 158 $\mu$m line of atomic carbon [CII] may be the only way to derive M_dyn. As the distribution and kinematics of the ISM tracer affects the determination of M_dyn, it is important to quantify the relative distributions of HI, CO and [CII]. HI and CO are well-characterised observationally, however, for [CII] only very few measurements exist. Here we compare observations of CO, HI, and [CII] emission of a sample of nearby galaxies, drawn from the HERACLES, THINGS and KINGFISH surveys. We find that within R_25, the average [CII] exponential radial profile is slightly shallower than that of the CO, but much steeper than the HI distribution. This is also reflected in the integrated spectrum ("global profile"), where the [CII] spectrum looks more like that of the CO than that of the HI. For one galaxy, a spectrally resolved comparison of integrated spectra was possible; other comparisons were limited by the intrinsic line-widths of the galaxies and the coarse velocity resolution of the [CII] data. Using high-spectral-resolution SOFIA [CII] data of a number of star forming regions in two nearby galaxies, we find that their [CII] linewidths agree better with those of the CO than the HI. As the radial extent of a given ISM tracer is a key input in deriving M_dyn from spatially unresolved data, we conclude that the relevant length-scale to use in determining M_dyn based on [CII] data, is that of the well-characterised CO distribution. This length scale is similar to that of the optical disk.Comment: Accepted for publication in the Astronomical Journa

El corsé de Milwaukee en la escoliosis idiopática: resultados en el plano sagital

Se presentan los resultados obtenidos en el tratamiento de la escoliosis idiopática con el cors é de Milwauke e en el plano sagital. Han sido estudiado s 51 paciente s (44 mujere s y 7 varones) con una edad medi a al inicio del tratamient o de 13 años. El tipo de curva según la clasificación de King y Moe corresponde a 18 del tipo I, 16 del tipo II, 12 del III, 1 del IV, 2 del V y dos curvas lumbares. El seguimiento medio de la serie fue de 5 años. El 88% de los pacientes (45 casos) mostró una disminución del valor angular medio de la cifosis torácica. El promedio de disminución fue de 10° que representa el 32% del valor angular inicial. El 86% (44 pacientes) mostró aplanamiento de la lordosis lumbar , pasando de un valor inicial medi o de 59°, a un valor final del tratamiento de 49°. Esta disminución representa un 16% del valor inicial. La edad, el tipo y la elasticidad de la curva, así como el Risser no mostraron relación con la evolución de las curvas en el plano sagital.The results obtained in the sagittal plane in patients with idiopathic scoliosis treated by Milwauke e brace are presented. A series of 51 patients (44 females, 7 males) with average of 13 years, wer e included in the study. Using the King and More's classification, 18 patients had type I curves,16 type II, 12 type III, 1 type IV and 2 patients showed tipe V curves. Two had lumbar curves. The mean follow-up was 5 years. In 45 patients (88%) the thoracic Kyphosis showed a decrease of 10° in average angular value (32% of initial value). 44 patients (86%) showed loss of lumbar lordosis, passing from an initial average value of 59° to 49° of final average value (16%). Age, type of the curve, Risser and bending test wer e not related with the evolution of curvatures in the sagittal plane