Counting chirps : acoustic monitoring of cryptic frogs

Funding for the frog survey was received from the National Geographic Society/Waitt Grants Program (No. W184-11). The EPSRC and NERC helped to fund this research through a PhD grant (No. EP/1000917/1) to D.L.B. R.A. and G.J.M. acknowledge initiative funding from the National Research Foundation of South Africa.1 .  Global amphibian declines have resulted in a vital need for monitoring programmes that follow population trends. Monitoring using advertisement calls is ideal as choruses are undisturbed during data collection. However, methods currently employed by managers frequently rely on trained observers, and/or do not provide density data on which to base trends. 2 .  This study explores the utility of monitoring using acoustic spatially explicit capture-recapture (aSECR) with time of arrival (ToA) and signal strength (SS) as a quantitative monitoring technique to measure call density of a threatened but visually cryptic anuran, the Cape peninsula moss frog Arthroleptella lightfooti. 3 .  The relationships between temporal and environmental variables (date, rainfall, temperature) and A. lightfooti call density at three study sites on the Cape peninsula, South Africa were examined. Acoustic data, collected from an array of six microphones over four months during the winter breeding season, provided a time series of call density estimates. 4 .  Model selection indicated that call density was primarily associated with seasonality fitted as a quadratic function. Call density peaked mid-breeding season. At the main study site, the lowest recorded mean call density (0·160 calls m-2 min-1) occurred in May and reached its peak mid-July (1·259 calls m-2 min-1). The sites differed in call density, but also the effective sampling area. 5 .  Synthesis and applications.The monitoring technique, acoustic spatially explicit capture–recapture (aSCR), quantitatively estimates call density without disturbing the calling animals or their environment, while time of arrival (ToA) and signal strength (SS) significantly add to the accuracy of call localisation, which in turn increases precision of call density estimates without the need for specialist field staff. This technique appears ideally suited to aid the monitoring of visually cryptic, acoustically active species.Publisher PDFPeer reviewe

The Effective Particle-Hole Interaction and the Optical Response of Simple Metal Clusters

Following Sham and Rice [L. J. Sham, T. M. Rice, Phys. Rev. 144 (1966) 708] the correlated motion of particle-hole pairs is studied, starting from the general two-particle Greens function. In this way we derive a matrix equation for eigenvalues and wave functions, respectively, of the general type of collective excitation of a N-particle system. The interplay between excitons and plasmons is fully described by this new set of equations. As a by-product we obtain - at least a-posteriori - a justification for the use of the TDLDA for simple-metal clusters.Comment: RevTeX, 15 pages, 5 figures in uufiles format, 1 figure avaible from [email protected]

The beta function of the multichannel Kondo model

The beta function of the multichannel Kondo model is calculated exactly in the limit of large spin N and channel number M=gamma*N, with constant gamma. There are no corrections in any finite order of 1/N. One zero is found at a finite coupling strength, showing directly the Non--Fermi liquid behavior of the model. This renormalization group flow allows to introduce a variational principle for the entropy, to obtain the low temperature thermodynamics. Such in particular the low temperature thermodynamics of the non--crossing approximation to the Kondo model becomes accessible.Comment: 4 page

Kinks in the Kondo problem

We find the exact quasiparticle spectrum for the continuum Kondo problem of $k$ species of electrons coupled to an impurity of spin $S$. In this description, the impurity becomes an immobile quasiparticle sitting on the boundary. The particles are ``kinks'', which can be thought of as field configurations interpolating between adjacent wells of a potential with $k+1$ degenerate minima. For the overscreened case $k>2S$, the boundary has this kink structure as well, which explains the non-integer number of boundary states previously observed. Using simple arguments along with the consistency requirements of an integrable theory, we find the exact elastic $S$-matrix for the quasiparticles scattering among themselves and off of the boundary. This allows the calculation of the exact free energy, which agrees with the known Bethe ansatz solution.Comment: 9 pages +1 figur

Bi-allelic GAD1 variants cause a neonatal onset syndromic developmental and epileptic encephalopathy.

Developmental and epileptic encephalopathies are a heterogeneous group of early-onset epilepsy syndromes dramatically impairing neurodevelopment. Modern genomic technologies have revealed a number of monogenic origins and opened the door to therapeutic hopes. Here we describe a new syndromic developmental and epileptic encephalopathy caused by bi-allelic loss-of-function variants in GAD1, as presented by 11 patients from six independent consanguineous families. Seizure onset occurred in the first 2 months of life in all patients. All 10 patients, from whom early disease history was available, presented with seizure onset in the first month of life, mainly consisting of epileptic spasms or myoclonic seizures. Early EEG showed suppression-burst or pattern of burst attenuation or hypsarrhythmia if only recorded in the post-neonatal period. Eight patients had joint contractures and/or pes equinovarus. Seven patients presented a cleft palate and two also had an omphalocele, reproducing the phenotype of the knockout Gad1-/- mouse model. Four patients died before 4 years of age. GAD1 encodes the glutamate decarboxylase enzyme GAD67, a critical actor of the γ-aminobutyric acid (GABA) metabolism as it catalyses the decarboxylation of glutamic acid to form GABA. Our findings evoke a novel syndrome related to GAD67 deficiency, characterized by the unique association of developmental and epileptic encephalopathies, cleft palate, joint contractures and/or omphalocele

Berezinskii-Kosterlitz-Thouless Transition in Spin-Charge Separated Superconductor

A model for spin-charge separated superconductivity in two dimensions is introduced where the phases of the spinon and holon order parameters couple gauge-invariantly to a statistical gauge-field representing chiral spin-fluctuations. The model is analyzed in the continuum limit and in the low-temperature limit. In both cases we find that physical electronic phase correlations show a superconducting-normal phase transition of the Berezinskii-Kosterlitz-Thouless type, while statistical gauge-field excitations are found to be strictly gapless. The normal-to-superconductor phase boundary for this model is also obtained as a function of carrier density, where we find that its shape compares favorably with that of the experimentally observed phase diagram for the oxide superconductors.Comment: 35 pages, TeX, CSLA-P-93-

On the Corrections to Dashen's Theorem

The electromagnetic corrections to the masses of the pseudoscalar mesons $\pi$ and $K$ are considered. We calculate in chiral perturbation theory the contributions which arise from resonances within a photon loop at order $O(e^2 m_q)$. Within this approach we find rather moderate deviations to Dashen's theorem.Comment: 14 pages, sligthly enlarged version; a numerical error is corrected and the embedding of the figures is improved. The complete paper, including figures, is also available via anonymous ftp at ftp://www-ttp.physik.uni-karlsruhe.de/ , or via www at http://www-ttp.physik.uni-karlsruhe.de/cgi-bin/preprints/; to be published in Phys.Rev.

An assessment of validity and responsiveness of generic measures of health-related quality of life in hearing impairment

This article is made available through the Brunel Open Access Publishing Fund. This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.Purpose: This review examines psychometric performance of three widely used generic preference-based measures, that is, EuroQol 5 dimensions (EQ-5D), Health Utility Index 3 (HUI3) and Short-form 6 dimensions (SF-6D) in patients with hearing impairments. Methods: A systematic search was undertaken to identify studies of patients with hearing impairments where health state utility values were measured and reported. Data were extracted and analysed to assess the reliability, validity (known group differences and convergent validity) and responsiveness of the measures across hearing impairments. Results: Fourteen studies (18 papers) were included in the review. HUI3 was the most commonly used utility measures in hearing impairment. In all six studies, the HUI3 detected difference between groups defined by the severity of impairment, and four out of five studies detected statistically significant changes as a result of intervention. The only study available suggested that EQ-5D only had weak ability to discriminate difference between severity groups, and in four out of five studies, EQ-5D failed to detected changes. Only one study involved the SF-6D; thus, the information is too limited to conclude on its performance. Also evidence for the reliability of these measures was not found. Conclusion: Overall, the validity and responsiveness of the HUI3 in hearing impairment was good. The responsiveness of EQ-5D was relatively poor and weak validity was suggested by limited evidence. The evidence on SF-6D was too limited to make any judgment. More head-to-head comparisons of these and other preference measures of health are required.Medical Research Counci

Photosynthetic characterization of three dominant plant species in the saline-alkaline soil of the Yellow River Delta, China

The diurnal variations of photosynthesis of three dominant species, including Glycine soja, Phragmites australis, and Cynanchum chinensis, in the Yellow River Delta in China have been studied under the same natural conditions using a Li-6400 portable photosynthesis system. The results showed that the curves of diurnal variations of net photosynthetic rate (P-N) of the three plants were different. The diurnal variation of P-N on C. chinensis was a midday depression pattern and had two peaks. However, P-N of G. soja and P. australis showed single-peak curves. The transpiration rate (E) of G. soja was significantly higher than that of P. australis and C. chinensis, both showed single-peak curves. In general, the diurnal course of stomatal conductance (g(s)) followed the same pattern of P-N. A similar diurnal pattern of intercellular CO2 concentration (C-i), vapor pressure deficit (VPD), and water use efficiency (WUE) was observed among different species. VPD showed single-peak curves, while WUE was characterized by double-peak curves, which was contrary to C-i. Linear correlations among photosynthetic variables and key environmental factors indicate high positive correlations between P-N and E, P-N and photosynthetic active radiation, P-N and leaf temperature (T-leaf), P-N and VPD, and between P-N and g(s) except C. chinensis. Negative correlations among P-N and relative humidity, P-N and C-i were found. The irradiance response curves derived from the leaves were substantially affected by different species. C. chinensis showed highest apparent quantum efficiency, followed by P. australis and G. soja, while apparent dark respiration (R-d), convexity (k), light saturation point, and maximum gross CO2 assimilation rate (P-max) of G. soja were higher than those of P. australis and C. chinensis. The irradiance response curve of P-N and WUE of different plant species followed the same order: G. soja>C. chinensis>P. australis. They were both higher than most of other species. It was concluded that plant species adapting to the saline-alkaline habitat showed higher photosynthesis. In addition, G. soja is also effective to improve saline-alkaline soil quality

First-trimester or second-trimester screening, or both, for Down's syndrome

BACKGROUND: It is uncertain how best to screen pregnant women for the presence of fetal Down's syndrome: to perform first-trimester screening, to perform second-trimester screening, or to use strategies incorporating measurements in both trimesters.METHODS: Women with singleton pregnancies underwent first-trimester combined screening (measurement of nuchal translucency, pregnancy-associated plasma protein A [PAPP-A], and the free beta subunit of human chorionic gonadotropin at 10 weeks 3 days through 13 weeks 6 days of gestation) and second-trimester quadruple screening (measurement of alpha-fetoprotein, total human chorionic gonadotropin, unconjugated estriol, and inhibin A at 15 through 18 weeks of gestation). We compared the results of stepwise sequential screening (risk results provided after each test), fully integrated screening (single risk result provided), and serum integrated screening (identical to fully integrated screening, but without nuchal translucency).RESULTS: First-trimester screening was performed in 38,167 patients; 117 had a fetus with Down's syndrome. At a 5 percent false positive rate, the rates of detection of Down's syndrome were as follows: with first-trimester combined screening, 87 percent, 85 percent, and 82 percent for measurements performed at 11, 12, and 13 weeks, respectively; with second-trimester quadruple screening, 81 percent; with stepwise sequential screening, 95 percent; with serum integrated screening, 88 percent; and with fully integrated screening with first-trimester measurements performed at 11 weeks, 96 percent. Paired comparisons found significant differences between the tests, except for the comparison between serum integrated screening and combined screening.CONCLUSIONS: First-trimester combined screening at 11 weeks of gestation is better than second-trimester quadruple screening but at 13 weeks has results similar to second-trimester quadruple screening. Both stepwise sequential screening and fully integrated screening have high rates of detection of Down's syndrome, with low false positive rates