Early warning system of natural hazards and decrease of climat impact from aviation; ALARM funded project

Aviation safety can be jeopardised by multiple hazards arising from natural phenomena, e.g., severe weather, aerosols/gases from natural hazard, and space weather. Furthermore, there are the anthropogenic emissions and climate impact of aviation that could be reduced. To mitigate such risk and/or to decrease climate impact, tactical decision-making processes could be enhanced through the development of multihazard monitoring and Early Warning System (EWS). With this objective in mind, ALARM consortium has implemented alert products (i.e., observations, detection and data access in near realtime) and tailored product (notifications, flight level — FL contamination, risk area, and visualization of emission/risk level) related to Natural Airborne Hazard (NAH, i.e., volcanic, dust and smoke clouds) and environmental hotspots. New selective detection, nowcasting and forecasts of such risks for aviation have been implemented as part of ALARM prototype EWS. This system has two functionalities. One is to provide alerts on a global coverage using remote sensing from satellites and models (focus on NAH, space weather activity and environmental hotspots). A second focuses on detecting severe weather and exceptional SO2 conditions around a selection of few airports, on providing nowcasts and forecasts of risk conditions

Human adipose-derived stem cells reduce receptor-interacting protein 1, receptor-interacting protein 3, and mixed lineage kinase domain-like pseudokinase as necroptotic markers in rat model of Alzheimer's disease

OBJECTIVES: Alzheimer's disease (AD) is a constant, developing brain impairment that is described as the aggregation of misfolded amyloid-beta-peptide (Ab) and abnormal tau protein in the brain. Stem cell therapy became a favorable candidate for the regeneration of neurodegenerative disorders like AD, but there is still shortage of knowledge about the underlying mechanisms. The goal of this survey was the determination of the necroptotic pathway as the possible mechanism for the effect of human adipose-derived stem cells (hADSCs) in the rat model of AD. MATERIALS AND METHODS: Twelve rats were consumed, dividing into four groups: Control, sham, AD model and AD + stem cell groups. We utilized Nissl and Thioflavin S staining for determining histological changes and immunofluorescent techniques for evaluating necroptotic markers in different regions of the hippocampus. RESULTS: The confirmation of AD model was approved with histological examination. The findings indicated more distinct Thio-S stain and an increased number of dead cells in AD rats comparing to other groups. Alternatively, the dead cells number in the CA3 area significantly lessened in AD + stem cell group comparing to AD group. Data showed that hADSCs significantly decreased the expression of necroptotic markers (receptor-interacting protein 1, receptor-interacting protein 3 and mixed lineage kinase domain-like pseudokinase (MLKL)) in AD + stem cell group compared to AD group in different regions of the hippocampus. CONCLUSION: Our findings revealed that the intravenous injection of hADSCs reduced necroptosis and consequently declined the death of neuronal cells in the hippocampus of AD rats. © 2020 Wolters Kluwer Medknow Publications. All rights reserved