On the Stokes number and characterization of aerosol deposition in the respiratory airways

Aerosol deposition in the respiratory airways has traditionally been examined in terms of the Stokes number based on the reference flow timescale. This choice leads to large scatter in deposition efficiency when plotted against the reference Stokes number because the velocity and length scales experienced by advected particles deviate considerably from the reference values. A time-average of the particle local Stokes number should be adopted instead. Our results demonstrate that this average, or effective, Stokes number can deviate significantly from the reference value, in particular in the intermediate Stokes number range where variation across subjects is largest

Mapping Functions in Health-Related Quality of Life: Mapping From Two Cancer-Specific Health-Related Quality-of-Life Instruments to EQ-5D-3L.

BACKGROUND: Clinical trials in cancer frequently include cancer-specific measures of health but not preference-based measures such as the EQ-5D that are suitable for economic evaluation. Mapping functions have been developed to predict EQ-5D values from these measures, but there is considerable uncertainty about the most appropriate model to use, and many existing models are poor at predicting EQ-5D values. This study aims to investigate a range of potential models to develop mapping functions from 2 widely used cancer-specific measures (FACT-G and EORTC-QLQ-C30) and to identify the best model. METHODS: Mapping models are fitted to predict EQ-5D-3L values using ordinary least squares (OLS), tobit, 2-part models, splining, and to EQ-5D item-level responses using response mapping from the FACT-G and QLQ-C30. A variety of model specifications are estimated. Model performance and predictive ability are compared. Analysis is based on 530 patients with various cancers for the FACT-G and 771 patients with multiple myeloma, breast cancer, and lung cancer for the QLQ-C30. RESULTS: For FACT-G, OLS models most accurately predict mean EQ-5D values with the best predicting model using FACT-G items with similar results using tobit. Response mapping has low predictive ability. In contrast, for the QLQ-C30, response mapping has the most accurate predictions using QLQ-C30 dimensions. The QLQ-C30 has better predicted EQ-5D values across the range of possible values; however, few respondents in the FACT-G data set have low EQ-5D values, which reduces the accuracy at the severe end. CONCLUSIONS: OLS and tobit mapping functions perform well for both instruments. Response mapping gives the best model predictions for QLQ-C30. The generalizability of the FACT-G mapping function is limited to populations in moderate to good health

Prediction of flow and aerosol deposition in the extrathoracic airways using an implicit immersed boundary method

The effect of intrasubject variation on the turbulent flow and aerosol deposition in the extrathoracic airways is studied in two realistic mouth-throat geometries from the same subject. An immersed boundary method is applied which simplifies the task of grid generation for the complex extrathoracic geometries and allows the use of a structured grid solver. Curvilinear grids that roughly follow the shape of the geometries are adopted, allowing for much higher resolution within the geometries than Cartesian grids commonly used in IB methods. An added advantage is that the grid lines are approximately aligned with the streamlines, which reduces numerical diffusive errors. The numerical simulations allow us to explain in vitro aerosol deposition data in the literature for the same mouth-throat models. The position of the tongue during inhalation is shown to have a significant impact on both the mean flow patterns and the turbulence intensities, which in turn affects extrathoracic deposition

Self Piercing Riveting for Metal-Polymer Joints

Self-Piercing Riveting (SPR) is a sheet metal joining technique based on the insertion of a rivet into two or more sheets, with no preparatory hole. This process has gained wide diffusion in the automotive industry, due to the increasing use of materials alternative to steel, that are difficult or impossible to join with traditional techniques. In particular, polymeric materials are becoming increasingly used, due to their favorable weight/strength ratio. This paper reports the results of experimental investigations, aimed at identifying the variables affecting the mechanical characteristics of mixed metal-plastic joints. A statistic model for the optimization of the geometrical parameters has been computed. The paper demonstrates that self-piercing riveting appears competitive for metal/polymer junction. The results analyzed in light of statistical techniques show that some geometrical parameters affect joint performance more than others and can therefore be used as independent variables for joint performance optimizatio

The Reach-Avoid Problem for Constant-Rate Multi-Mode Systems

A constant-rate multi-mode system is a hybrid system that can switch freely among a finite set of modes, and whose dynamics is specified by a finite number of real-valued variables with mode-dependent constant rates. Alur, Wojtczak, and Trivedi have shown that reachability problems for constant-rate multi-mode systems for open and convex safety sets can be solved in polynomial time. In this paper, we study the reachability problem for non-convex state spaces and show that this problem is in general undecidable. We recover decidability by making certain assumptions about the safety set. We present a new algorithm to solve this problem and compare its performance with the popular sampling based algorithm rapidly-exploring random tree (RRT) as implemented in the Open Motion Planning Library (OMPL).Comment: 26 page

Hsc66 substrate specificity is directed toward a discrete region of the iron-sulfur cluster template protein IscU

Hsc66 and Hsc20 comprise a specialized chaperone system important for the assembly of iron-sulfur clusters in Escherchia coli. Only a single substrate, the Fe/S template protein IscU, has been identified for the Hsc66/Hsc20 system, but the mechanism by which Hsc66 selectively binds IscU is unknown. We have investigated Hsc66 substrate specificity using phage display and a peptide array of IscU. Screening of a heptameric peptide phage display library revealed that Hsc66 prefers peptides with a centrally located Pro-Pro motif. Using a cellulose-bound peptide array of IscU we determined that Hsc66 interacts specifically with a region (residues 99-103, LPPVK) that is invariant among all IscU family members. A synthetic peptide (ELPPVKIHC) corresponding to IscU residues 98-106 behaves in a similar manner to native IscU, stimulating the ATPase activity of Hsc66 with similar affinity as IscU, preventing Hsc66 suppression of bovine rhodanese aggregation, and interacting with the peptide-binding domain of Hsc66. Unlike native IscU, however, the synthetic peptide is not bound by Hsc20 and does not synergistically stimulate Hsc66 ATPase activity with Hsc20. Our results indicate that Hsc66 and Hsc20 recognize distinct regions of IscU and further suggest that Hsc66 will not bind LPPVK motifs with high affinity in vivo unless they are in the context of native IscU and can be directed to Hsc66 by Hsc20

Effect of field tilting on the vortices in irradiated Bi-2212

We report on transport measurements in a Bi-2212 single crystal with columnar defects parallel to the c-axis. The tilt of the magnetic field away from the direction of the tracks is studied for filling factors f=B_z/B_phi<1. Near the Bose Glass transition temperature T_BG, the angular scaling laws are verified and we find the field independent critical exponents nu'=1.1 and z'=5.30. Finally, above H_perpC we evidence the signature of a smectic-A like vortex phase. These experimental results provide support for the Bose Glass theory.Comment: 2 pages LaTeX, 2 EPS figures, uses fleqn and espcrc2 style macros. Submitted to Proceedings of M2S-HTSC-V