A hepatoid carcinoma of the pancreatic head

Hepatoid carcinoma (HC) is an extremely rare form of neoplasm. Its cellular structure resembles that of a hepatocellular carcinoma (HCC). To date, only 26 cases of hepatoid carcinoma of the pancreas have been reported in the literature. We report the diagnosis of a hepatoid carcinoma of the pancreatic head in a 78-year-old male patient. The tumor was detected incidentally during routine abdominal ultrasound scanning. Laboratory tests did not show any abnormalities except for a monoclonal gammopathy of undetermined significance. After CT, MRI, and laparoscopic biopsy that failed to obtain the diagnosis, the patient underwent a Whipple procedure. The final pathology report described a hepatoid carcinoma of the pancreatic head (pathological T3, N0 (0/10), L0, V0, R0, M0). After the patient recovered, no further therapy was recommended by the tumor board and he was discharged. Regular follow-up was suggested; however, the patient suddenly died of acute coronary artery disease 2 months after surgery

Lifetime of d-holes at Cu surfaces: Theory and experiment

We have investigated the hole dynamics at copper surfaces by high-resolution angle-resolved photoemission experiments and many-body quasiparticle GW calculations. Large deviations from a free-electron-like picture are observed both in the magnitude and the energy dependence of the lifetimes, with a clear indication that holes exhibit longer lifetimes than electrons with the same excitation energy. Our calculations show that the small overlap of d- and sp-states below the Fermi level is responsible for the observed enhancement. Although there is qualitative good agreement of our theoretical predictions and the measured lifetimes, there still exist some discrepancies pointing to the need of a better description of the actual band structure of the solid.Comment: 15 pages, 7 figures, 1 table, to appear in Phys. Rev.

A very conscientious brand: A case study of the BBC's current affairs series Panorama

The reputation of British current affairs and documentary series such as the BBC's Panorama, Channel 4’s Dispatches or the now defunct Granada series World in Action have rested on an image of conscientious ‘public service’. These popular, long running series have, at various points in their history, acted as the ‘conscience of the nation’, seeking to expose social injustice, investigate misdemeanours by the powerful and take on venal or corrupt vested interest. The BBC’s flagship current affairs series Panorama is Britain’s longest running television programme and, according to the Panorama website, ‘the world’s longest running investigative TV show’. It has provided a template for other current affairs series both in Britain, Europe and around the world while undergoing several transformations in form and style since its launch in 1953, the latest and arguably most dramatic being in 2007. This article will chart the development of Panorama as a distinctive, ‘flagship' current affairs series over six decades. It will attempt to answer why the Panorama brand has survived so long, while so many other notable current affairs series have not. Using research and material from Bournemouth University’s Panorama Archive, the Video Active website, the BFI and other European archives this article explores the development of an iconic current affairs series that has, at different stages in its history, proved a template for other news and current affairs programmes. Various breaks and continuities are highlighted in Panorama’s history and identity, and an attempt will be made to characterise and specify the Panorama ‘brand’ and pinpoint the series’ successes and failures in reinventing itself in a rapidly changing media context

A BioBrick compatible strategy for genetic modification of plants

Background: Plant biotechnology can be leveraged to produce food, fuel, medicine, and materials. Standardized methods advocated by the synthetic biology community can accelerate the plant design cycle, ultimately making plant engineering more widely accessible to bioengineers who can contribute diverse creative input to the design process. Results: This paper presents work done largely by undergraduate students participating in the 2010 International Genetically Engineered Machines (iGEM) competition. Described here is a framework for engineering the model plant Arabidopsis thaliana with standardized, BioBrick compatible vectors and parts available through the Registry of Standard Biological Parts (http://www.partsregistry.org). This system was used to engineer a proof-of-concept plant that exogenously expresses the taste-inverting protein miraculin. Conclusions: Our work is intended to encourage future iGEM teams and other synthetic biologists to use plants as a genetic chassis. Our workflow simplifies the use of standardized parts in plant systems, allowing the construction and expression of heterologous genes in plants within the timeframe allotted for typical iGEM projects.Molecular and Cellular Biolog

Supine posture changes lung volumes and increases ventilation heterogeneity in cystic fibrosis

INTRODUCTION: Lung Clearance Index (LCI) is recognised as an early marker of cystic fibrosis (CF) lung disease. The effect of posture on LCI however is important when considering longitudinal measurements from infancy and when comparing LCI to imaging studies. METHODS: 35 children with CF and 28 healthy controls (HC) were assessed. Multiple breath washout (MBW) was performed both sitting and supine in triplicate and analysed for LCI, Scond, Sacin, and lung volumes. These values were also corrected for the Fowler dead-space to create 'alveolar' indices. RESULTS: From sitting to supine there was a significant increase in LCI and a significant decrease in FRC for both CF and HC (p<0.01). LCI, when adjusted to estimate 'alveolar' LCI (LCIalv), increased the magnitude of change with posture for both LCIalv and FRCalv in both groups, with a greater effect of change in lung volume in HC compared with children with CF. The % change in LCIalv for all subjects correlated significantly with lung volume % changes, most notably tidal volume/functional residual capacity (Vtalv/FRCalv (r = 0.54,p<0.001)). CONCLUSION: There is a significant increase in LCI from sitting to supine, which we believe to be in part due to changes in lung volume and also increasing ventilation heterogeneity related to posture. This may have implications in longitudinal measurements from infancy to older childhood and for studies comparing supine imaging methods to LCI

Developments in the classification and nomenclature of arthropod-infecting large DNA viruses that contain pif genes

Viruses of four families of arthropod-specific, large dsDNA viruses (the nuclear arthropod large DNA viruses, or NALDVs) possess homologs of genes encoding conserved components involved in the baculovirus primary infection mechanism. The presence of such homologs encoding per os infectivity factors (pif genes), along with their absence from other viruses and the occurrence of other shared characteristics, suggests a common origin for the viruses of these families. Therefore, the class Naldaviricetes was recently established, accommodating these four families. In addition, within this class, the ICTV approved the creation of the order Lefavirales for three of these families, whose members carry homologs of the baculovirus genes that code for components of the viral RNA polymerase, which is responsible for late gene expression. We further established a system for the binomial naming of all virus species in the order Lefavirales, in accordance with a decision by the ICTV in 2019 to move towards a standardized nomenclature for all virus species. The binomial species names for members of the order Lefavirales consist of the name of the genus to which the species belongs (e.g., Alphabaculovirus), followed by a single epithet that refers to the host species from which the virus was originally isolated. The common names of viruses and the abbreviations thereof will not change, as the format of virus names lies outside the remit of the ICTV

The Midwest Quarterly; Vol. 24 No. 1

in this issue. . . ARTHUR L. KALLEBERG assesses the recent, tentative attempts to reconcile Marxism with Christianity and concludes that proponents of both must make concessions to effect a more perfect union. Middlebush Professor of Political Science at the University of Missouri-Columbia, Kalleberg has published numerous scholarly articles in his discipline and is now at work on a book dealing with social justice. Through a discussion of certain aspects of medieval history, JOHN M. THEILMANN examines the value for historians of symbolic anthropology and finds much to recommend a mutual sharing of the two approaches. Author of many papers and articles on medieval history and now at work on studies employing the insights outlined in the essay presented here, Theilman holds the post of Lecturer in History and Political Science at the University of Missouri-Rolla. ASHBY BLAND CROWDER invites contemporary architects to cast aside the arid, inhumane style of Modern Movement architecture in favor of an eclecticism which will restore the historical connection of art~ architecture, and humanity. Author of numerous works on Robert Browning and of poetry and scholarly articles on other topics, Crowder has just been named to the M. E. and Ima Graves Peace Professorship in English, American Literature, and the Humanities at Hendrix College in Conway, Arkansas. J. V. BRUMMELS teaches at Wayne State College, Wayne; Nebraska. His first full-length collection of poems, 614 Pearl, has just been released by Abbatoir Editions. MICHAEL BURNS teaches at Southwest Missouri State University, Springfield, Missouri. JEANNINE DOBBS has new work in Akros and Amicus Journal. She lives in Merrimack, New Hampshire. WILLIAM HATHAWAY teaches at Louisiana State in Baton Rouge. Two of his books of poems were published by Ithaca House and his latest collection, The Gymnast of Inertia, is from the LSU Press. HAROLD WITT\u27s new collection of poems, The Snow Prince, was published this summer by Blue Unicorn. He lives in Orinda, California. In the visual arts, suggests CHARLES STROH, the split-brain dichotomy recently put forward to isolate creativity (right hemisphere) from analytical, discursive thought (left hemisphere) simply cannot explain the complex process of artistic expression. Now Chairman of the Art Department at Kansas State University, Stroh has combined stints as a visiting artist and a lecturer on art with exhibitions of his lithographs and drawings in a large number of juried shows and galleries. ROBERT W. HOFFERT, investigating linkage of the family and governmental bureaucracy, discovers not only significant changes in the purpose and definition of the family, but also serious threats to the family posed by bureaucratic usurpation. Associate Professor of Political Science at Colorado State University, Hoffert has published articles on David Hume and Alfred North Whitehead and on the use of Scripture in the development and expression of the political ideas of John Locke and Thomas Hobbes. Decrying the thoughtless pursuit of security, stability, and sameness, JOHN L. DUSSEAU urges instead attention to individual excellence, challenge, and the passionate search for clear understanding. For twenty-five years editor-in-chief at W. B. Saunders Company in Philadelphia, a publisher of scientific works with particular emphasis on medical science, Dusseau has, since his retirement in 1977, devoted his creative energies to essays reflecting his views on writing and publishing. His splendid Monotheism in Ancient Egypt appeared in the Autumn, 1981, issue of The Midwest Quarterly. Devon Jersild is a graduate of Dartmouth College. Her poems have appeared in Tar River Poetry and Other Poetry. She lives in Middlebury, Vermont. Eugene H. DeGruson is special collections librarian at Pittsburg State University and one of the founding editors of the Little Balkans Review