462 research outputs found
Detection of residual host cells after bone marrow transplantation using non-isotopic in situ hybridization
The Yangian of sl(n|m) and the universal R-matrix
In this paper we study Yangians of sl(n|m) superalgebras. We derive the
universal R-matrix and evaluate it on the fundamental representation obtaining
the standard Yang R-matrix with unitary dressing factors. For m=0, we directly
recover up to a CDD factor the well-known S-matrices for relativistic
integrable models with su(N) symmetry. Hence, the universal R-matrix found
provides an abstract plug-in formula, which leads to results obeying
fundamental physical constraints: crossing symmetry, unitrarity and the
Yang-Baxter equation. This implies that the Yangian double unifies all desired
symmetries into one algebraic structure. In particular, our analysis is valid
in the case of sl(n|n), where one has to extend the algebra by an additional
generator leading to the algebra gl(n|n). We find two-parameter families of
scalar factors in this case and provide a detailed study for gl(1|1).Comment: 24 pages, 2 figure
Two-loop AdS_5 x S^5 superstring: testing asymptotic Bethe ansatz and finite size corrections
We continue the investigation of two-loop string corrections to the energy of
a folded string with a spin S in AdS_5 and an angular momentum J in S^5, in the
scaling limit of large J and S with ell=pi J/(lambda^(1/2) ln S)=fixed. We
compute the generalized scaling function at two-loop order f_2(ell) both for
small and large values of ell matching the predictions based on the asymptotic
Bethe ansatz. In particular, in the small ell expansion, we derive an exact
integral form for the ell-dependent coefficient of the Catalan's constant term
in f_2(ell). Also, by resumming a certain subclass of multi-loop Feynman
diagrams we obtain an exact expression for the leading (ln ell) part of
f(lambda^(1/2), ell) which is valid to any order in the alpha'~1/lambda^(1/2)
expansion. At large ell the string energy has a BMN-like expansion and the
first few leading coefficients are expected to be the same at weak and at
strong coupling. We provide a new example of this non-renormalization for the
term which is generated at two loops in string theory and at one-loop in gauge
theory (sub-sub-leading in 1/J). We also derive a simple algebraic formula for
the term of maximal transcendentality in f_2(ell) expanded at large ell. In the
second part of the paper we initiate the study of 2-loop finite size
corrections to the string energy by formally compactifying the spatial
world-sheet direction in the string action expanded near long fast-spinning
string. We observe that the leading finite-size corrections are of "Casimir"
type coming from terms containing at least one massless propagator. We consider
in detail the one-loop order (reproducing the leading Landau-Lifshitz model
prediction) and then focus on the two-loop contributions to the (1/ln S) term
(for J=0). We find that in a certain regularization scheme used to discard
power divergences the two-loop coefficient of the (1/ln S) term appears to
vanish.Comment: 50 pages, 4 figures v2: typos corrected, references adde
From Scattering Amplitudes to the Dilatation Generator in N=4 SYM
The complete spin chain representation of the planar N=4 SYM dilatation
generator has long been known at one loop, where it involves leading
nearest-neighbor 2 -> 2 interactions. In this work we use superconformal
symmetry to derive the unique solution for the leading L -> 2 interactions of
the planar dilatation generator for arbitrarily large L. We then propose that
these interactions are given by the scattering operator that has N=4 SYM
tree-level scattering amplitudes as matrix elements. We provide compelling
evidence for this proposal, including explicit checks for L=2,3 and a proof of
consistency with superconformal symmetry.Comment: 39 pages, v2: reference added and minor changes, published versio
Controlling trapping potentials and stray electric fields in a microfabricated ion trap through design and compensation
Recent advances in quantum information processing with trapped ions have
demonstrated the need for new ion trap architectures capable of holding and
manipulating chains of many (>10) ions. Here we present the design and detailed
characterization of a new linear trap, microfabricated with scalable
complementary metal-oxide-semiconductor (CMOS) techniques, that is well-suited
to this challenge. Forty-four individually controlled DC electrodes provide the
many degrees of freedom required to construct anharmonic potential wells,
shuttle ions, merge and split ion chains, precisely tune secular mode
frequencies, and adjust the orientation of trap axes. Microfabricated
capacitors on DC electrodes suppress radio-frequency pickup and excess
micromotion, while a top-level ground layer simplifies modeling of electric
fields and protects trap structures underneath. A localized aperture in the
substrate provides access to the trapping region from an oven below, permitting
deterministic loading of particular isotopic/elemental sequences via
species-selective photoionization. The shapes of the aperture and
radio-frequency electrodes are optimized to minimize perturbation of the
trapping pseudopotential. Laboratory experiments verify simulated potentials
and characterize trapping lifetimes, stray electric fields, and ion heating
rates, while measurement and cancellation of spatially-varying stray electric
fields permits the formation of nearly-equally spaced ion chains.Comment: 17 pages (including references), 7 figure
Demonstration of integrated microscale optics in surface-electrode ion traps
In ion trap quantum information processing, efficient fluorescence collection
is critical for fast, high-fidelity qubit detection and ion-photon
entanglement. The expected size of future many-ion processors require scalable
light collection systems. We report on the development and testing of a
microfabricated surface-electrode ion trap with an integrated high numerical
aperture (NA) micromirror for fluorescence collection. When coupled to a low NA
lens, the optical system is inherently scalable to large arrays of mirrors in a
single device. We demonstrate stable trapping and transport of 40Ca+ ions over
a 0.63 NA micromirror and observe a factor of 1.9 enhancement in photon
collection compared to the planar region of the trap.Comment: 15 pages, 8 figure
TBA-like equations and Casimir effect in (non-)perturbative AdS/CFT
We consider high spin, , long twist, , planar operators (asymptotic
Bethe Ansatz) of strong SYM. Precisely, we compute the minimal
anomalous dimensions for large 't Hooft coupling to the lowest order
of the (string) scaling variable with GKP string size . At the leading order ,
we can confirm the O(6) non-linear sigma model description for this bulk term,
without boundary term . Going further, we derive,
extending the O(6) regime, the exact effect of the size finiteness. In
particular, we compute, at all loops, the first Casimir correction (in terms of the infinite size O(6) NLSM), which reveals only one
massless mode (out of five), as predictable once the O(6) description has been
extended. Consequently, upon comparing with string theory expansion, at one
loop our findings agree for large twist, while reveal for negligible twist,
already at this order, the appearance of wrapping. At two loops, as well as for
next loops and orders, we can produce predictions, which may guide future
string computations.Comment: Version 2 with: new exact expression for the Casimir energy derived
(beyond the first two loops of the previous version); UV theory formulated
and analysed extensively in the Appendix C; origin of the O(6) NLSM
scattering clarified; typos correct and references adde
Tyrosine kinase inhibitors improve long-term outcome of allogeneic hematopoietic stem cell transplantation for adult patients with philadelphia chromosome positive acute lymphoblastic leukemia
This study aimed to determine the impact of tyrosine kinase inhibitors given pre- and post-allogeneic stem cell transplantation on long-term outcome of patients allografted for Philadelphia chromosome-positive acute lymphoblastic leukemia. This retrospective analysis from the EBMT Acute Leukemia Working Party included 473 de novoPhiladelphia chromosome-positive acute lymphoblastic leukemia patients in first complete remission who underwent an allogeneic stem cell transplantation using a human leukocyte antigen-identical sibling or human leukocyte antigen-matched unrelated donor between 2000 and 2010. Three hundred and ninety patients received tyrosine kinase inhibitors before transplant, 329 at induction and 274 at consolidation. Kaplan-Meier estimates of leukemia-free survival, overall survival, cumulative incidences of relapse incidence, and non-relapse mortality at five years were 38%, 46%, 36% and 26%, respectively. In multivariate analysis, tyrosine-kinase inhibitors given before allogeneic stem cell transplantation was associated with a better overall survival (HR=0.68; P=0.04) and was associated with lower relapse incidence (HR=0.5;P=0.01). In the post-transplant period, multivariate analysis identified prophylactic tyrosine-kinase inhibitor administration to be a significant factor for improved leukemia-free survival (HR=0.44; P=0.002) and overall survival (HR=0.42; P=0.004), and a lower relapse incidence (HR=0.40; P=0.01). Over the past decade, administration of tyrosine kinase inhibitors before allogeneic stem cell transplantation has significantly improved the long-term allogeneic stem cell trans
On the dressing factors, Bethe equations and Yangian symmetry of strings on AdS3 × S3 × T4
Integrability is believed to underlie the AdS3/CFT2 correspondence with sixteen supercharges. We elucidate the role of massless modes within this integrable framework. Firstly, we find the dressing factors that enter the massless and mixed-mass worldsheet S matrix. Secondly, we derive a set of all-loop Bethe Equations for the closed strings, determine their symmetries and weak-coupling limit. Thirdly, we investigate the underlying Yangian symmetry in the massless sector and show that it fits into the general framework of Yangian integrability. In addition, we compare our S matrix in the near-relativistic limit with recent perturbative worldsheet calculations of Sundin and Wulff
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