The minimal N=4 no-scale model from generalized dimensional reduction

We consider the generalized dimensional reduction of pure ungauged N=4, D=5 supergravity, where supersymmetry is spontaneously broken to N=2 or N=0 with identically vanishing scalar potential. We explicitly construct the resulting gauged D=4 theory coupled to a single vector multiplet, which provides the minimal N=4 realization of a no-scale model. We discuss its relation with the standard classification of N=4 gaugings, extensions to non-compact twists and to higher dimensions, the N=2 theories obtained via consistent Z_2 orbifold projections and prospects for further generalizations.Comment: 1+28 pages, no figures, JHEP3 LaTeX, published versio

A “reverse pharmacology” approach for developing an anti-malarial phytomedicine

A "reverse pharmacology" approach to developing an anti-malarial phytomedicine was designed and implemented in Mali, resulting in a new standardized herbal anti-malarial after six years of research. The first step was to select a remedy for development, through a retrospective treatment-outcome study. The second step was a dose-escalating clinical trial that showed a dose-response phenomenon and helped select the safest and most efficacious dose. The third step was a randomized controlled trial to compare the phytomedicine to the standard first-line treatment. The last step was to identify active compounds which can be used as markers for standardization and quality control. This example of "reverse pharmacology" shows that a standardized phytomedicine can be developed faster and more cheaply than conventional drugs. Even if both approaches are not fully comparable, their efficiency in terms of public health and their complementarity should be thoroughly considered

GIANO-TNG spectroscopy of red supergiants in the young star cluster RSGC3

The Scutum complex in the inner disk of the Galaxy has a number of young star clusters dominated by red supergiants that are heavily obscured by dust extinction and observable only at infrared wavelengths. These clusters are important tracers of the recent star formation and chemical enrichment history in the inner Galaxy. During the technical commissioning and as a first science verification of the GIANO spectrograph at the Telescopio Nazionale Galileo, we secured high-resolution (R=50,000) near-infrared spectra of five red supergiants in the young Scutum cluster RSGC3. Taking advantage of the full YJHK spectral coverage of GIANO in a single exposure, we were able to measure several tens of atomic and molecular lines that were suitable for determining chemical abundances. By means of spectral synthesis and line equivalent width measurements, we obtained abundances of Fe and iron-peak elements such as Ni, Cr, and Cu, alpha (O, Mg, Si, Ca, Ti), other light elements (C, N, F, Na, Al, and Sc), and some s-process elements (Y, Sr). We found average half-solar iron abundances and solar-scaled [X/Fe] abundance patterns for most of the elements, consistent with a thin-disk chemistry. We found depletion of [C/Fe] and enhancement of [N/Fe], consistent with standard CN burning, and low 12C/13C abundance ratios (between 9 and 11), which require extra-mixing processes in the stellar interiors during the post-main sequence evolution. We also found local standard of rest V(LSR)=106 km/s and heliocentric V(HEL)=90 km/s radial velocities with a dispersion of 2.3 km/s. The inferred radial velocities, abundances, and abundance patterns of RSGC3 are very similar to those previously measured in the other two young clusters of the Scutum complex, RSGC1 and RSGC2, suggesting a common kinematics and chemistry within the Scutum complex

GEANT simulation of energy losses of slow hadrons

The algorithm of the simulation of energy losses for hadrons with kinetic energy down to few eV is described. The details of its implementation in Geant4 are discussed. The comparison of the results of simulation with the experimental data is presented

The TNG Near Infrared Camera Spectrometer

NICS (acronym for Near Infrared Camera Spectrometer) is the near-infrared cooled camera-spectrometer that has been developed by the Arcetri Infrared Group at the Arcetri Astrophysical Observatory, in collaboration with the CAISMI-CNR for the TNG (the Italian National Telescope Galileo at La Palma, Canary Islands, Spain). As NICS is in its scientific commissioning phase, we report its observing capabilities in the near-infrared bands at the TNG, along with the measured performance and the limiting magnitudes. We also describe some technical details of the project, such as cryogenics, mechanics, and the system which executes data acquisition and control, along with the related software.Comment: 7 pages, 5 figures, compiled with A&A macros. A&A in pres

Lumbar epidural fentanyl: segmental spread and effect on temporal summation and muscle pain

Background. Despite extensive use, different aspects of the pharmacological action of epidural fentanyl have not been clarified. We applied a multi‐modal sensory test procedure to investigate the effect of epidural fentanyl on segmental spread, temporal summation (as a measure for short‐lasting central hyperexcitability) and muscle pain. Methods. Thirty patients received either placebo, 50 or 100 µg single dose of fentanyl epidurally (L2-3), in a randomized, double‐blind fashion. Heat pain tolerance thresholds at eight dermatomes from S1 to fifth cranial nerve (assessment of segmental spread), pain threshold to transcutaneous repeated electrical stimulation of the sural nerve (assessment of temporal summation) and pain intensity after injection of hypertonic saline into the tibialis anterior muscle (assessment of muscle pain) were recorded. Results. Fentanyl 100 µg, but not 50 µg, produced analgesia to heat stimulation only at L2. Surprisingly, no effect at S1 was detected. Both fentanyl doses significantly increased temporal summation threshold and decreased muscle pain intensity. Conclusions. The findings suggest that a single lumbar epidural dose of fentanyl should be injected at the spinal interspace corresponding to the dermatomal site of pain. Increased effect on L2 compared with S1 suggests that drug effect on spinal nerve roots and binding to opioid receptors on the dorsal root ganglia may be more important than traditionally believed for the segmental effect of epidurally injected fentanyl. Epidural fentanyl increases temporal summation threshold and could therefore contribute to prevention and treatment of central hypersensitivity states. I.M. injection of hypertonic saline is a sensitive technique for detecting the analgesic action of epidural opioids. Br J Anaesth 2003; 90: 467-7

GEANT: detector description and simulation tool

As the scale and complexity of High Energy Physics experiments increase, simulation studies require more and more care and become essential to design and optimise the detectors, develop and test the reconstruction and analysis programs, and interpret the experimental data. GEANT is a system of detector description and simulation tools that help physicists in such studies

Argemone mexicana decoction versus artesunate-amodiaquine for the management of malaria in Mali: Policy and public-health implications

A classic way of delaying drug resistance is to use an alternative when possible. We tested the malaria treatment Argemone mexicana decoction (AM), a validated self-prepared traditional medicine made with one widely available plant and safe across wide dose variations. In an attempt to reflect the real situation in the home-based management of malaria in a remote Malian village, 301 patients with presumed uncomplicated malaria (median age 5 years) were randomly assigned to receive AM or artesunate-amodiaquine [artemisinin combination therapy (ACT)] as first-line treatment. Both treatments were well tolerated. Over 28 days, second-line treatment was not required for 89% (95% CI 84.1-93.2) of patients on AM, versus 95% (95% CI 88.8-98.3) on ACT. Deterioration to severe malaria was 1.9% in both groups in children aged ≤5 years (there were no cases in patients aged >5 years) and 0% had coma/convulsions. AM, now government-approved in Mali, could be tested as a first-line complement to standard modern drugs in high-transmission areas, in order to reduce the drug pressure for development of resistance to ACT, in the management of malaria. In view of the low rate of severe malaria and good tolerability, AM may also constitute a first-aid treatment when access to other antimalarials is delaye

GIANO-TNG spectroscopy of red supergiants in the young star cluster RSGC2

The inner disk of the Galaxy has a number of young star clusters dominated by red supergiants that are heavily obscured by dust extinction and observable only at infrared wavelengths. These clusters are important tracers of the recent star formation and chemical enrichment history in the inner Galaxy. During the technical commissioning and as a first science verification of the GIANO spectrograph at the Telescopio Nazionale Galileo, we secured high-resolution (R~50,000) near-infrared spectra of three red supergiants in the young Scutum cluster RSGC2. Taking advantage of the full YJHK spectral coverage of GIANO in a single exposure, we were able to identify several tens of atomic and molecular lines suitable for chemical abundance determinations. By means of spectral synthesis and line equivalent width measurements, we obtained abundances of Fe and other iron-peak elements such as V, Cr, Ni, of alpha (O, Mg, Si, Ca and Ti) and other light elements (C, N, Na, Al, K, Sc), and of some s-process elements (Y, Sr). We found iron abundances between half and one third solar and solar-scaled [X/Fe] abundance patterns of iron-peak, alpha and most of the light elements, consistent with a thin-disk chemistry. We found a depletion of [C/Fe] and enhancement of [N/Fe], consistent with CN burning, and low 12C/13C abundance ratios (between 9 and 11), requiring extra-mixing processes in the stellar interiors during the post-main sequence evolution. Finally, we found a slight [Sr/Fe] enhancement and a slight [Y/Fe] depletion (by a factor of <=2), with respect to solar.Comment: Paper accepted on A&

GEANT4 low energy electromagnetic models for electrons and photons

A set of physics processes has been developed in the Geant4 Simulation Toolkit to describe the electromagnetic interactions of photons and electrons with matter down to 250 eV. Preliminary comparisons of the models with experimental data show a satisfactory agreement