On the asymptotic normality of the Legendre-Stirling numbers of the second kind

For the Legendre-Stirling numbers of the second kind asymptotic formulae are derived in terms of a local central limit theorem. Thereby, supplements of the recently published asymptotic analysis of the Chebyshev-Stirling numbers are established. Moreover, we provide results on the asymptotic normality and unimodality for modified Legendre-Stirling numbers

Journeys to Open Educational Practice: UKOER/SCORE Review Final Report

In 2008 the JISC Good Intentions report concluded that the landscape around learning materials had changed sufficiently to support a range of sustainable models for sharing. The report charted and acknowledged the long history of approaches to support sharing that had helped to shape the landscape. Most of the models highlight a growing acknowledgement of the need to build and support open and sustainable communities to share practice and resources. Indeed such communities are often the key to sustaining the service, whichever model is adopted. This is the type of model most likely to encourage sharing between teachers as well as learners. The growing OER community is taking collaborative approaches to tackling the ongoing challenges of raising awareness, licensing and trust issues, and standards and technologies. The challenge for the UK now is to ensure that our HE institutions are enabled to create policies, practices and support their staff to accelerate the transformations required to contribute and benefit from this global movement. It is also vital to ensure that we capture the real picture of use and re-use of such services and collections to inform future OER programmes. HEFCE funding for OER initiatives followed this report in 2009 and has, in many ways, provided some of the scaffolding and support for a variety of individuals, communities and institutions to move forwards in their own journeys, whether they started years before in other contexts or had just joined on the road to open sharing

Afatinib use in recurrent epithelial ovarian carcinoma.

•Genomic tumor testing is an important tool in guiding treatment for gynecologic malignancies.•Targetable mutations may lead to new therapies in gynecologic cancer treatment.•Her2/neu mutations in serous ovarian carcinomas can be targeted with ERBB2 inhibitors.•Afatinib shows promising response rates in lung cancers carrying Her2/neu mutations.•Afatinib may be effective in serous ovarian tumors exhibiting Her2/neu or ERBB2 mutations