Transport of apolipoproteins A-I and A-II by human thoracic duct lymph

The daily transport of human plasma apolipoproteins A-I and A-II, triglyceride, and total cholesterol from the thoracic duct lymph into plasma was measured in 2 subjects before and 3 subjects after renal transplantation. Lymph triglyceride transport was ~83% of the daily ingested fat loads, whereas lymph cholesterol transport was consistently greater than the amount of daily ingested cholesterol. Lymph apolipoprotein transport significantly (P < 0.05) exceeded the predicted apolipoprotein synthesis rate by an average of 659±578 mg/d for apolipoprotein A-I and 109±59 mg/d for apolipoprotein A-II among the 5 subjects. It is estimated that 22-77% (apolipoprotein A-I) and 28-82% (apolipoprotein A-II) of daily total body apolipoprotein synthesis takes place in the intestine. Lymph high density lipoprotein particles are mostly high density lipoprotein(2b) and high density lipoprotein(2a) and have a greater overall relative triglyceride content and a smaller relative cholesteryl ester content when compared with homologous plasma high density lipoproteins. The major quantity of both lymph apolipoprotein A-I (81±8%) and apolipoprotein A-II (90±11%) was found within high density lipoproteins with almost all of the remainder found in chylomicrons and very low density lipoproteins. The combined results are consistent with a major contribution of the intestine to total body synthesis of apolipoprotein A-I and apolipoprotein A-II. An important role of lymph in returning filtered apolipoprotein to plasma in association with high density lipoproteins is proposed. Accompanying the return of filtered apolipoprotein to the plasma is a probable transformation, both in size and composition, of at least some of the lymph high density lipoprotein(2b) and high density lipoprotein(2a) particles into high density lipoprotein3

The globular clusters-stellar haloes connection in early type galaxies

This paper explores if, and to what an extent, the stellar populations of early type galaxies can be traced through the colour distribution of their globular cluster systems. The analysis, based on a galaxy sample from the Virgo ACS data, is an extension of a previous approach that has been successful in the cases of the giant ellipticals NGC 1399 and NGC 4486, and assumes that the two dominant GC populations form along diffuse stellar populations sharing the cluster chemical abundances and spatial distributions. The results show that a) Integrated galaxy colours can be matched to within the photometric uncertainties and are consistent with a narrow range of ages; b) The inferred mass to luminosity ratios and stellar masses are within the range of values available in the literature; c) Most globular cluster systems occupy a thick plane in the volume space defined by the cluster formation efficiency, total stellar mass and projected surface mass density. The formation efficiency parameter of the red clusters shows a dependency with projected stellar mass density that is absent for the blue globulars. In turn, the brightest galaxies appear clearly detached from that plane as a possible consequence of major past mergers; d) The stellar mass-metallicity relation is relatively shallow but shows a slope change at $M_*\approx 10^{10} M_\odot$. Galaxies with smaller stellar masses show predominantly unimodal globular cluster colour distributions. This result may indicate that less massive galaxies are not able to retain chemically enriched intestellar matter.Comment: 19 pages, 10 figure

Leaders of Reform: Progressive Republicans in Kansas, 1900-1916

In Leaders of Reform Robert Sherman La Forte examines the intricacies of shifting factions within the state majority party over a two decade period, from the Boss-Busters and political machines of the early 1900s through the formation of a new party behind Theodore Roosevelt in 1913. He discusses the motives, activities, accomplishments, and failures of the progressive Republicans. He provides excellent vignettes of major leaders such as William Allen White, Arthur Capper, Joseph L. Bristow, and Charles Curtis, as well as lesser-known characters such as Walter Roscoe Stubbs, Edward H. Hoch, and Cy Leland, Jr. In providing a detailed analysis of virtually all Kansas progressive Republican leaders during the era, La Forte has made a valuable contribution to both state and national political history. Description Robert Sherman La Forte was professor of history at the University of North Texas, where he taught for thirty years. In addition to this book, he coauthored three books on World War II history and the authorized history of the University of North Texas. With a New Foreword by Charles Delgadillo. Charles Delgadillo is lecturer in history at the California State Polytechnic University, Pomona, and Norco College, in California. He is the author of Crusader for Democracy: The Political Life of William Allen White. This Kansas Open Books title is funded by a grant from the National Endowment for the Humanities and the Andrew W. Mellon Foundation Humanities Open Book Program.https://digitalcommons.pittstate.edu/kansas_open_books/1038/thumbnail.jp

Leaders of Reform: Progressive Republicans in Kansas, 1900-1916

Robert Sherman La Forte was professor of history at the University of North Texas, where he taught for thirty years. In addition to this book, he coauthored three books on World War II history and the authorized history of the University of North Texas. With a New Foreword by Charles Delgadillo. Charles Delgadillo is lecturer in history at the California State Polytechnic University, Pomona, and Norco College, in California. He is the author of Crusader for Democracy: The Political Life of William Allen White.This Kansas Open Books title is funded by a grant from the National Endowment for the Humanities and the Andrew W. Mellon Foundation Humanities Open Book Program.In Leaders of Reform Robert Sherman La Forte examines the intricacies of shifting factions within the state majority party over a two decade period, from the Boss-Busters and political machines of the early 1900s through the formation of a new party behind Theodore Roosevelt in 1913. He discusses the motives, activities, accomplishments, and failures of the progressive Republicans. He provides excellent vignettes of major leaders such as William Allen White, Arthur Capper, Joseph L. Bristow, and Charles Curtis, as well as lesser-known characters such as Walter Roscoe Stubbs, Edward H. Hoch, and Cy Leland, Jr. In providing a detailed analysis of virtually all Kansas progressive Republican leaders during the era, La Forte has made a valuable contribution to both state and national political history

The Hybrid Nano-Biointerface between Proteins/Peptides and Two-Dimensional Nanomaterials

In typical protein-nanoparticle surface interactions, the biomolecule surface binding and consequent conformational changes are intermingled with each other and are pivotal to the multiple functional properties of the resulting hybrid bioengineered nanomaterial. In this review, we focus on the peculiar properties of the layer formed when biomolecules, especially proteins and peptides, face two-dimensional (2D) nanomaterials, to provide an overview of the state-of-the-art knowledge and the current challenges concerning the biomolecule coronas and, in general, the 2D nano-biointerface established when peptides and proteins interact with the nanosheet surface. Specifically, this review includes both experimental and simulation studies, including some recent machine learning results of a wide range of nanomaterial and peptide/protein systems

The central dark matter content of early-type galaxies: scaling relations and connections with star formation histories

We examine correlations between the masses, sizes, and star formation histories for a large sample of low-redshift early-type galaxies, using a simple suite of dynamical and stellar populations models. We confirm an anti-correlation between size and stellar age, and survey for trends with the central content of dark matter (DM). An average relation between central DM density and galaxy size of ~ Reff^-2 provides the first clear indication of cuspy DM haloes in these galaxies -- akin to standard LCDM haloes that have undergone adiabatic contraction. The DM density scales with galaxy mass as expected, deviating from suggestions of a universal halo profile for dwarf and late-type galaxies. We introduce a new fundamental constraint on galaxy formation by finding that the central DM fraction decreases with stellar age. This result is only partially explained by the size-age dependencies, and the residual trend is in the opposite direction to basic DM halo expectations. Therefore we suggest that there may be a connection between age and halo contraction, and that galaxies forming earlier had stronger baryonic feedback which expanded their haloes, or else lumpier baryonic accretion that avoided halo contraction. An alternative explanation is a lighter initial mass function for older stellar populations.Comment: 24 pages, 23 figures. MNRAS, submitted with minor modifications following referee report

YAP regulates cell mechanics by controlling focal adhesion assembly

Hippo effectors YAP/TAZ act as on-off mechanosensing switches by sensing modifications in extracellular matrix (ECM) composition and mechanics. The regulation of their activity has been described by a hierarchical model in which elements of Hippo pathway are under the control of focal adhesions (FAs). Here we unveil the molecular mechanism by which cell spreading and RhoA GTPase activity control FA formation through YAP to stabilize the anchorage of the actin cytoskeleton to the cell membrane. This mechanism requires YAP co-transcriptional function and involves the activation of genes encoding for integrins and FA docking proteins. Tuning YAP transcriptional activity leads to the modification of cell mechanics, force development and adhesion strength, and determines cell shape, migration and differentiation. These results provide new insights into the mechanism of YAP mechanosensing activity and qualify this Hippo effector as the key determinant of cell mechanics in response to ECM cues.Peer reviewe

Spacelike Singularities and Hidden Symmetries of Gravity

We review the intimate connection between (super-)gravity close to a spacelike singularity (the "BKL-limit") and the theory of Lorentzian Kac-Moody algebras. We show that in this limit the gravitational theory can be reformulated in terms of billiard motion in a region of hyperbolic space, revealing that the dynamics is completely determined by a (possibly infinite) sequence of reflections, which are elements of a Lorentzian Coxeter group. Such Coxeter groups are the Weyl groups of infinite-dimensional Kac-Moody algebras, suggesting that these algebras yield symmetries of gravitational theories. Our presentation is aimed to be a self-contained and comprehensive treatment of the subject, with all the relevant mathematical background material introduced and explained in detail. We also review attempts at making the infinite-dimensional symmetries manifest, through the construction of a geodesic sigma model based on a Lorentzian Kac-Moody algebra. An explicit example is provided for the case of the hyperbolic algebra E10, which is conjectured to be an underlying symmetry of M-theory. Illustrations of this conjecture are also discussed in the context of cosmological solutions to eleven-dimensional supergravity.Comment: 228 pages. Typos corrected. References added. Subject index added. Published versio