Astaxanthin vs placebo on arterial stiffness, oxidative stress and inflammation in renal transplant patients (Xanthin): a randomised controlled trial

Background: There is evidence that renal transplant recipients have accelerated atherosclerosis manifest by increased cardiovascular morbidity and mortality. The high incidence of atherosclerosis is, in part, related to increased arterial stiffness, vascular dysfunction, elevated oxidative stress and inflammation associated with immunosuppressive therapy. The dietary supplement astaxanthin has shown promise as an antioxidant and anti-inflammatory therapeutic agent in cardiovascular disease. The aim of this trial is to investigate the effects of astaxanthin supplementation on arterial stiffness, oxidative stress and inflammation in renal transplant patients

Antioxidant requirements of endurance athletes: Implications for health

This review discusses studies investigating the effects of antioxidant supplementation on exercise-induced oxidative stress with a focus on the health implications. The aim is to determine antioxidant requirements for endurance athletes. Overall, differences in methodology make it difficult to compare the relatively small number of published studies on this topic. The types of studies needed to more adequately assess the health effects of antioxidant supplements in athletes (long-term interventions with hard end points) have not been done. Therefore, there is currently insufficient evidence to recommend antioxidant supplements for endurance athletes

How to do science: A guide to researching human physiology

How to do science: a guide to researching human physiology has been written for students of the life sciences who are actively engaged in the scientific process. A lot of support is available for students learning scientific facts, but we found that it was harder to find resources to support students to become scientists.This ebook introduces you to what it means to be a scientist. You will learn about the scientific method and how to do many tasks of a scientist, your roles and responsibilities as a scientist as well as possible career paths, and how to use your skills as a science graduate to get a leg up in the job market.ISBN: 978-0-9953727-2-6</p

How to do science: A guide to researching human physiology

How to do science: a guide to researching human physiology has been written for students of the life sciences who are actively engaged in the scientific process. A lot of support is available for students learning scientific facts, but we found that it was harder to find resources to support students to become scientists.This ebook introduces you to what it means to be a scientist. You will learn about the scientific method and how to do many tasks of a scientist, your roles and responsibilities as a scientist as well as possible career paths, and how to use your skills as a science graduate to get a leg up in the job market.ISBN: 978-0-9953727-2-6</p

La Trobe eBureau presents: It's publishing, but not as we know it – creating equitable and engaging resources for online learning

This panel discussion was hosted by the La Trobe eBureau as part of Open Access Week Australasia 2021. The panelists talked about the experience of writing an open textbook, the benefits and successes of this, and the challenges for normalising a culture of open educational practices at La Trobe. Facilitator: Fiona SalisburyPanel: Brianna Julien, Katherine Seaton, and Louise LexisPresenter: Steven Chang</div

Metformin intake associates with better cognitive function in patients with Huntington's disease

Huntington's disease (HD) is an inherited, dominant neurodegenerative disorder caused by an abnormal expansion of CAG triplets in the huntingtin gene (htt). Despite extensive efforts to modify the progression of HD thus far only symptomatic treatment is available. Recent work suggests that treating invertebrate and mice HD models with metformin, a well-known AMPK activator which is used worldwide to treat type 2-diabetes, reduces mutant huntingtin from cells and alleviates many of the phenotypes associated to HD. Herein we report statistical analyses of a sample population of participants in the Enroll-HD database, a world-wide observational study on HD, to assess the effect of metformin intake in HD patients respect to cognitive status using linear models. This cross-sectional study shows for the first time that the use of metformin associates with better cognitive function in HD patients