Energy-Efficient selective activation in Femtocell Networks

Provisioning the capacity of wireless networks is difficult when peak load is significantly higher than average load, for example, in public spaces like airports or train stations. Service providers can use femtocells and small cells to increase local capacity, but deploying enough femtocells to serve peak loads requires a large number of femtocells that will remain idle most of the time, which wastes a significant amount of power. To reduce the energy consumption of over-provisioned femtocell networks, we formulate a femtocell selective activation problem, which we formalize as an integer nonlinear optimization problem. Then we introduce GREENFEMTO, a distributed femtocell selective activation algorithm that deactivates idle femtocells to save power and activates them on-the-fly as the number of users increases. We prove that GREENFEMTO converges to a locally Pareto optimal solution and demonstrate its performance using extensive simulations of an LTE wireless system. Overall, we find that GREENFEMTO requires up to 55% fewer femtocells to serve a given user load, relative to an existing femtocell power-saving procedure, and comes within 15% of a globally optimal solution

Semantic bottleneck for computer vision tasks

This paper introduces a novel method for the representation of images that is semantic by nature, addressing the question of computation intelligibility in computer vision tasks. More specifically, our proposition is to introduce what we call a semantic bottleneck in the processing pipeline, which is a crossing point in which the representation of the image is entirely expressed with natural language , while retaining the efficiency of numerical representations. We show that our approach is able to generate semantic representations that give state-of-the-art results on semantic content-based image retrieval and also perform very well on image classification tasks. Intelligibility is evaluated through user centered experiments for failure detection

Power adjustment and scheduling in OFDMA femtocell networks

Densely-deployed femtocell networks are used to enhance wireless coverage in public spaces like office buildings, subways, and academic buildings. These networks can increase throughput for users, but edge users can suffer from co-channel interference, leading to service outages. This paper introduces a distributed algorithm for network configuration, called Radius Reduction and Scheduling (RRS), to improve the performance and fairness of the network. RRS determines cell sizes using a Voronoi-Laguerre framework, then schedules users using a scheduling algorithm that includes vacancy requests to increase fairness in dense femtocell networks. We prove that our algorithm always terminate in a finite time, producing a configuration that guarantees user or area coverage. Simulation results show a decrease in outage probability of up to 50%, as well as an increase in Jain's fairness index of almost 200%

Limb sounders tracking topographic gravity wave activity from the stratosphere to the ionosphere around midlatitude Andes

Several studies have shown that the surroundings of the highest Andes mountains at midlatitudes in the Southern Hemisphere exhibit gravity waves (GWs) generated by diverse sources which may traverse the troposphere and then penetrate the upper layers if conditions are favorable. There is a specific latitude band where that mountain range is nearly perfectly aligned with the north‐south direction, which favors the generation of wavefronts parallel to this orientation. This fact may allow an optimization of procedures to identify topographic GW in some of the observations. We analyze data per season to the east and west of these Andes latitudes to find possible significant differences in GW activity between both sectors. GW effects generated by topography and convection are expected essentially on the eastern side. We use satellite data from two different limb sounding methods: the Global Positioning System radio occultation (RO) technique and the Sounding of the Atmosphere using Broadband Emission Radiometry instrument, which are complementary with respect to the height intervals, in order to study the effects of GW from the stratosphere to the ionosphere. Activity becomes quantified by the GW average potential energy in the stratosphere and mesosphere and by the electron density variance content in the ionosphere. Consistent larger GW activity on the eastern sector is observed from the stratosphere to the ionosphere (night values). However, this fact remains statistically significant at the 90% significance level only during winter, when GWs generated by topography dominate the eastern sector. On the contrary, it is usually assumed that orographic GWs have nearly zero horizontal phase speed and will therefore probably be filtered at some height in the neutral atmosphere. However, this scheme relies on the assumption that the wind is uniform and constant. Our results also suggest that it is advisable to separate night and day cases to study GWs in the ionosphere, as it is more difficult to find significant statistical differences during daytime. This may happen because perturbations induced by GWs during daytime are more likely to occur in a disturbed environment that may hinder the identification of the waves.Fil: Alexander, Pedro Manfredo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física de Buenos Aires; ArgentinaFil: de la Torre, Alejandro. Universidad Austral. Facultad de Ingeniería; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Schmidt, T.. German Research Centre for Geosciences; AlemaniaFil: Llamedo Soria, Pablo Martin. Universidad Austral. Facultad de Ingeniería; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Hierro, Rodrigo Federico. Universidad Austral. Facultad de Ingeniería; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentin

ACCase 6 is the essential acetyl-CoA carboxylase involved in fatty acid and mycolic acid biosynthesis in mycobacteria

Mycolic acids are essential for the survival, virulence and antibiotic resistance of the human pathogen Mycobacterium tuberculosis. Inhibitors of mycolic acid biosynthesis, such as isoniazid and ethionamide, have been used as efficient drugs for the treatment of tuberculosis. However, the increase in cases of multidrug-resistant tuberculosis has prompted a search for new targets and agents that could also affect synthesis of mycolic acids. In mycobacteria, the acyl-CoA carboxylases (ACCases) provide the building blocks for de novo fatty acid biosynthesis by fatty acid synthase (FAS) I and for the elongation of FAS I products by the FAS II complex to produce meromycolic acids. By generating a conditional mutant in the accD6 gene of Mycobacterium smegmatis, we demonstrated that AccD6 is the essential carboxyltransferase component of the ACCase 6 enzyme complex implicated in the biosynthesis of malonyl-CoA, the substrate of the two FAS enzymes of Mycobacterium species. Based on the conserved structure of the AccD5 and AccD6 active sites we screened several inhibitors of AccD5 as potential inhibitors of AccD6 and found that the ligand NCI-172033 was capable of inhibiting AccD6 with an IC50 of 8 ìM. The compound showed bactericidal activity against several pathogenic Mycobacterium species by producing a strong inhibition of both fatty acid and mycolic acid biosynthesis at minimal inhibitory concentrations. Overexpression of accD6 in M. smegmatis conferred resistance to NCI-172033, confirming AccD6 as the main target of the inhibitor. These results define the biological role of a key ACCase in the biosynthesis of membrane and cell envelope fatty acids, and provide a new target, AccD6, for rational development of novel anti-mycobacterial drugsFil: Kurth, Daniel German. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Biología Molecular y Celular de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Biología Molecular y Celular de Rosario; ArgentinaFil: Gago, Gabriela Marisa. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Biología Molecular y Celular de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Biología Molecular y Celular de Rosario; ArgentinaFil: de la Iglesia, Agustina Inés. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Biología Molecular y Celular de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Biología Molecular y Celular de Rosario; ArgentinaFil: Bazet Lyonnet, Bernardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Biología Molecular y Celular de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Biología Molecular y Celular de Rosario; ArgentinaFil: Lin, Ting Wang. University of California; Estados UnidosFil: Morbidoni, Héctor Ricardo. Universidad Nacional de Rosario. Facultad de Ciencias Médicas; ArgentinaFil: Tsai, Shiou Chuan. University of California; Estados UnidosFil: Gramajo, Hugo Cesar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Biología Molecular y Celular de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Biología Molecular y Celular de Rosario; Argentin

Design of a compact objective for SWIR applications

Lately the short-wave infrared (SWIR) has become very important due to the recent appearance on the market of the small detectors with a large focal plane array. Military applications for SWIR cameras include handheld and airborne systems with long range detection requirements, but where volume and weight restrictions must be considered. In this paper we present three different designs of telephoto objectives that have been designed according to three different methods. Firstly the conventional method where the starting point of the design is an existing design. Secondly we will face design starting from the design of an aplanatic system. And finally the simultaneous multiple surfaces (SMS) method, where the starting point is the input wavefronts that we choose. The designs are compared in terms of optical performance, volume, weight and manufacturability. Because the objectives have been designed for the SWIR waveband, the color correction has important implications in the choice of glass that will be discussed in detai

Exchange Bias Induced by the Fe3O4 Verwey transition

We present a study of the exchange bias in different configurations of V2O3 thin films with ferromagnetic layers. The exchange bias is accompanied by a large vertical shift in the magnetization. These effects are only observed when V2O3 is grown on top of Ni80Fe20 permalloy. The magnitude of the vertical shift is as large as 60% of the total magnetization which has never been reported in any system. X-Ray diffraction studies show that the growth conditions promote the formation of a ferrimagnetic Fe3O4 interlayer. The change in the easy magnetization axis of Fe3O4 across the Verwey transition at 120 K is correlated with the appearance of exchange bias and vertical shift in magnetization. Both phenomena disappear above 120 K, indicating for the first time a direct relationship between the magnetic signature of the Verwey transition and exchange bias.Comment: Accepted for publication Physical Review

Severe loss-of-function mutations in the adrenocorticotropin receptor (ACTHR, MC2R) can be found in patients diagnosed with salt-losing adrenal hypoplasia

Objective: Familial glucocorticoid deficiency type I (FGD1) is a rare form of primary adrenal insufficiency resulting from recessive mutations in the ACTH receptor (MC2R, MC2R). Individuals with this condition typically present in infancy or childhood with signs and symptoms of cortisol insufficiency, but disturbances in the renin-angiotensin system, aldosterone synthesis or sodium homeostasis are not a well-documented association of FGD1. As ACTH stimulation has been shown to stimulate aldosterone release in normal controls, and other causes of hyponatraemia can occur in children with cortisol deficiency, we investigated whether MC2R changes might be identified in children with primary adrenal failure who were being treated for mineralocorticoid insufficiency. Design: Mutational analysis of MC2R by direct sequencing. Patients: Children (n = 22) who had been diagnosed with salt-losing forms of adrenal hypoplasia (19 isolated cases, 3 familial), and who were negative for mutations in DAX1 (NR0B1) and SF1 (NR5A1). Results: MC2R mutations were found in three individuals or kindred (I: homozygous S74I; II: novel compound heterozygous R146H/560delT; III: novel homozygous 579-581delTGT). These changes represent severely disruptive loss-of-function mutations in this G-protein coupled receptor, including the first reported homozygous frameshift mutation. The apparent disturbances in sodium homeostasis were mild, manifest at times of stress (e.g. infection, salt-restriction, heat), and likely resolved with time. Conclusions: MC2R mutations should be considered in children who have primary adrenal failure with apparent mild disturbances in renin-sodium homeostasis. These children may have been misdiagnosed as having salt-losing adrenal hypoplasia. Making this diagnosis has important implications for treatment, counselling and long-term prognosi