Near-threshold production of W±W^\pm, Z0Z^0 and H0H^0 at a fixed-target experiment at the future ultra-high-energy proton colliders

We outline the opportunities to study the production of the Standard Model bosons, $W^\pm$, $Z^0$ and $H^0$ at "low" energies at fixed-target experiments based at possible future ultra-high-energy proton colliders, \ie\ the High-Energy LHC, the Super proton-proton Collider and the Future Circular Collider -- hadron-hadron. These can be indeed made in conjunction with the proposed future colliders designed to reach up to $\sqrt{s}=100$ TeV by using bent crystals to extract part of the halo of the beam which would then impinge on a fixed target. Without disturbing the collider operation, this technique allows for the extraction of a substantial amount of particles in addition to serve for a beam-cleaning purpose. With this method, high-luminosity fixed-target studies at centre-of-mass energies above the $W^\pm$, $Z^0$ and $H^0$ masses, $\sqrt{s} \simeq 170-300$ GeV, are possible. We also discuss the possibility offered by an internal gas target, which can also be used as luminosity monitor by studying the beam transverse shape

Prospectives for A Fixed-Target ExpeRiment at the LHC: AFTER@LHC

We argue that the concept of a multi-purpose fixed-target experiment with the proton or lead-ion LHC beams extracted by a bent crystal would offer a number of ground-breaking precision-physics opportunities. The multi-TeV LHC beams will allow for the most energetic fixed-target experiments ever performed. The fixed-target mode has the advantage of allowing for high luminosities, spin measurements with a polarised target, and access over the full backward rapidity domain --uncharted until now-- up to x_F ~ -1.Comment: 6 pages, 1 table, LaTeX. Proceedings of the 36th International Conference on High Energy Physics (ICHEP2012), 4-11 July 2012, Melbourne, Australi

Spin physics at A Fixed-Target ExpeRiment at the LHC (AFTER@LHC)

We outline the opportunities for spin physics which are offered by a next generation and multi-purpose fixed-target experiment exploiting the proton LHC beam extracted by a bent crystal. In particular, we focus on the study of single transverse spin asymetries with the polarisation of the target.Comment: Contributed to the 20th International Spin Physics Symposium, SPIN2012, 17-22 September 2012, Dubna, Russia, 4 pages, LaTe

A Fixed-Target ExpeRiment at the LHC (AFTER@LHC) : luminosities, target polarisation and a selection of physics studies

We report on a future multi-purpose fixed-target experiment with the proton or lead ion LHC beams extracted by a bent crystal. The multi-TeV LHC beams allow for the most energetic fixed-target experiments ever performed. Such an experiment, tentatively named AFTER for "A Fixed-Target ExperRiment", gives access to new domains of particle and nuclear physics complementing that of collider experiments, in particular at RHIC and at the EIC projects. The instantaneous luminosity at AFTER using typical targets surpasses that of RHIC by more than 3 orders of magnitude. Beam extraction by a bent crystal offers an ideal way to obtain a clean and very collimated high-energy beam, without decreasing the performance of the LHC. The fixed-target mode also has the advantage of allowing for spin measurements with a polarised target and for an access over the full backward rapidity domain up to xF ~ - 1. Here, we elaborate on the reachable luminosities, the target polarisation and a selection of measurements with hydrogen and deuterium targets.Comment: 6 pages. Proceedings of the Sixth International Conference on Quarks and Nuclear Physics QNP2012 (16-20 April 2012, Ecole Polytechnique, Palaiseau,France

Effects of alteplase for acute stroke according to criteria defining the European Union and United States marketing authorizations: individual-patient-data meta-analysis of randomized trials

Background: The recommended maximum age and time window for intravenous alteplase treatment of acute ischemic stroke differs between the Europe Union and United States. Aims: We compared the effects of alteplase in cohorts defined by the current Europe Union or United States marketing approval labels, and by hypothetical revisions of the labels that would remove the Europe Union upper age limit or extend the United States treatment time window to 4.5 h. Methods: We assessed outcomes in an individual-patient-data meta-analysis of eight randomized trials of intravenous alteplase (0.9 mg/kg) versus control for acute ischemic stroke. Outcomes included: excellent outcome (modified Rankin score 0–1) at 3–6 months, the distribution of modified Rankin score, symptomatic intracerebral hemorrhage, and 90-day mortality. Results: Alteplase increased the odds of modified Rankin score 0–1 among 2449/6136 (40%) patients who met the current European Union label and 3491 (57%) patients who met the age-revised label (odds ratio 1.42, 95% CI 1.21−1.68 and 1.43, 1.23−1.65, respectively), but not in those outside the age-revised label (1.06, 0.90−1.26). By 90 days, there was no increased mortality in the current and age-revised cohorts (hazard ratios 0.98, 95% CI 0.76−1.25 and 1.01, 0.86–1.19, respectively) but mortality remained higher outside the age-revised label (1.19, 0.99–1.42). Similarly, alteplase increased the odds of modified Rankin score 0-1 among 1174/6136 (19%) patients who met the current US approval and 3326 (54%) who met a 4.5-h revised approval (odds ratio 1.55, 1.19−2.01 and 1.37, 1.17−1.59, respectively), but not for those outside the 4.5-h revised approval (1.14, 0.97−1.34). By 90 days, no increased mortality remained for the current and 4.5-h revised label cohorts (hazard ratios 0.99, 0.77−1.26 and 1.02, 0.87–1.20, respectively) but mortality remained higher outside the 4.5-h revised approval (1.17, 0.98–1.41). Conclusions: An age-revised European Union label or 4.5-h-revised United States label would each increase the number of patients deriving net benefit from alteplase by 90 days after acute ischemic stroke, without excess mortality

Predictions for p+p+Pb Collisions at sNN=5\sqrt{s_{NN}} = 5 TeV: Comparison with Data

Predictions made in Albacete {\it et al} prior to the LHC $p+$Pb run at $\sqrt{s_{NN}} = 5$ TeV are compared to currently available data. Some predictions shown here have been updated by including the same experimental cuts as the data. Some additional predictions are also presented, especially for quarkonia, that were provided to the experiments before the data were made public but were too late for the original publication are also shown here.Comment: 55 pages 35 figure

Heavy-flavour and quarkonium production in the LHC era: from proton-proton to heavy-ion collisions

This report reviews the study of open heavy-flavour and quarkonium production in high-energy hadronic collisions, as tools to investigate fundamental aspects of Quantum Chromodynamics, from the proton and nucleus structure at high energy to deconfinement and the properties of the Quark-Gluon Plasma. Emphasis is given to the lessons learnt from LHC Run 1 results, which are reviewed in a global picture with the results from SPS and RHIC at lower energies, as well as to the questions to be addressed in the future. The report covers heavy flavour and quarkonium production in proton-proton, proton-nucleus and nucleus-nucleus collisions. This includes discussion of the effects of hot and cold strongly interacting matter, quarkonium photo-production in nucleus-nucleus collisions and perspectives on the study of heavy flavour and quarkonium with upgrades of existing experiments and new experiments. The report results from the activity of the SaporeGravis network of the I3 Hadron Physics programme of the European Union 7th Framework Programme