A Calibrated Time Domain Envelope Measurement System for the Behavioral Modeling of Power Amplifiers

This paper presents a set-up which enables the generation and the calibrated time domain measurements of complex envelopes of modulated signals at both ports of non linear microwave power amplifiers. The architecture of the characterization tool is given. Examples of error corrected time domain envelopes at the input / output RF ports of a 36 dBm output power – 30dB power gain L-band SSPA are shown. Futhermore, the use of this characterization tool and a suitable processing of measurement data are applied to a novel measurement based behavioral modeling approach of non linear devices accounting for memory effects

Investigation of the Gravitational Potential Dependence of the Fine-Structure Constant Using Atomic Dysprosium

Radio-frequency E1 transitions between nearly degenerate, opposite parity levels of atomic dysprosium were monitored over an eight month period to search for a variation in the fine-structure constant. During this time period, data were taken at different points in the gravitational potential of the Sun. The data are fitted to the variation in the gravitational potential yielding a value of $(-8.7 \pm 6.6) \times 10^{-6}$ for the fit parameter $k_\alpha$. This value gives the current best laboratory limit. In addition, our value of $k_{\alpha}$ combined with other experimental constraints is used to extract the first limits on k_e and k_q. These coefficients characterize the variation of m_e/m_p and m_q/m_p in a changing gravitational potential, where m_e, m_p, and m_q are electron, proton, and quark masses. The results are $k_e = (4.9 \pm 3.9) \times 10^{-5}$ and $k_q = (6.6 \pm 5.2) \times 10^{-5}$.Comment: 6 pages, 3 figure

Anisotropic Hall Effect in Single Crystal Heavy Fermion YbAgGe

Temperature- and field-dependent Hall effect measurements are reported for YbAgGe, a heavy fermion compound exhibiting a field-induced quantum phase transition, and for two other closely related members of the RAgGe series: a non-magnetic analogue, LuAgGe and a representative, ''good local moment'', magnetic material, TmAgGe. Whereas the temperature dependent Hall coefficient of YbAgGe shows behavior similar to what has been observed in a number of heavy fermion compounds, the low temperature, field-dependent measurements reveal well defined, sudden changes with applied field; in specific for $H \perp c$ a clear local maximum that sharpens as temperature is reduced below 2 K and that approaches a value of 45 kOe - a value that has been proposed as the $T = 0$ quantum critical point. Similar behavior was observed for $H \| c$ where a clear minimum in the field-dependent Hall resistivity was observed at low temperatures. Although at our base temperatures it is difficult to distinguish between the field-dependent behavior predicted for (i) diffraction off a critical spin density wave or (ii) breakdown in the composite nature of the heavy electron, for both field directions there is a distinct temperature dependence of a feature that can clearly be associated with a field-induced quantum critical point at $T = 0$ persisting up to at least 2 K.Comment: revised versio

First direct mass-measurement of the two-neutron halo nucleus 6He and improved mass for the four-neutron halo 8He

The first direct mass-measurement of $^{6}$He has been performed with the TITAN Penning trap mass spectrometer at the ISAC facility. In addition, the mass of $^{8}$He was determined with improved precision over our previous measurement. The obtained masses are $m$($^{6}$He) = 6.018 885 883(57) u and $m$($^{8}$He) = 8.033 934 44(11) u. The $^{6}$He value shows a deviation from the literature of 4$\sigma$. With these new mass values and the previously measured atomic isotope shifts we obtain charge radii of 2.060(8) fm and 1.959(16) fm for $^{6}$He and $^{8}$He respectively. We present a detailed comparison to nuclear theory for $^6$He, including new hyperspherical harmonics results. A correlation plot of the point-proton radius with the two-neutron separation energy demonstrates clearly the importance of three-nucleon forces.Comment: 4 pages, 2 figure

First Penning-trap mass measurement in the millisecond half-life range: the exotic halo nucleus 11Li

In this letter, we report a new mass for $^{11}$Li using the trapping experiment TITAN at TRIUMF's ISAC facility. This is by far the shortest-lived nuclide, $t_{1/2} = 8.8 \rm{ms}$, for which a mass measurement has ever been performed with a Penning trap. Combined with our mass measurements of $^{8,9}$Li we derive a new two-neutron separation energy of 369.15(65) keV: a factor of seven more precise than the best previous value. This new value is a critical ingredient for the determination of the halo charge radius from isotope-shift measurements. We also report results from state-of-the-art atomic-physics calculations using the new mass and extract a new charge radius for $^{11}$Li. This result is a remarkable confluence of nuclear and atomic physics.Comment: Formatted for submission to PR

Human hypocretin and melanin-concentrating hormone levels are linked to emotion and social interaction.

The neurochemical changes underlying human emotions and social behaviour are largely unknown. Here we report on the changes in the levels of two hypothalamic neuropeptides, hypocretin-1 and melanin-concentrating hormone, measured in the human amygdala. We show that hypocretin-1 levels are maximal during positive emotion, social interaction and anger, behaviours that induce cataplexy in human narcoleptics. In contrast, melanin-concentrating hormone levels are minimal during social interaction, but are increased after eating. Both peptides are at minimal levels during periods of postoperative pain despite high levels of arousal. Melanin-concentrating hormone levels increase at sleep onset, consistent with a role in sleep induction, whereas hypocretin-1 levels increase at wake onset, consistent with a role in wake induction. Levels of these two peptides in humans are not simply linked to arousal, but rather to specific emotions and state transitions. Other arousal systems may be similarly emotionally specialized

Proteomic discovery and verification of serum amyloid A as a predictor marker of patients at risk of post-stroke infection: a pilot study

BACKGROUND: Post-stroke infections occur in 20-36% of stroke patients and are associated with high morbidity and mortality rates. Early identification of patients at risk of developing an infection could improve care via an earlier treatment leading to a better outcome. We used proteomic tools in order to discover biomarkers able to stratify patients at risk of post-stroke infection. METHODS: The post hoc analysis of a prospective cohort study including 40 ischemic stroke patients included 21 infected and 19 non-infected participants. A quantitative, isobaric labeling, proteomic strategy was applied to the plasma samples of 5 infected and 5 non-infected patients in order to highlight any significantly modulated proteins. A parallel reaction monitoring (PRM) assay was applied to 20 additional patients (10 infected and 10 non-infected) to verify discovery results. The most promising protein was pre-validated using an ELISA immunoassay on 40 patients and at different time points after stroke onset. RESULTS: Tandem mass analysis identified 266 proteins, of which only serum amyloid A (SAA1/2) was significantly (p = 0.007) regulated between the two groups of patients. This acute-phase protein appeared to be 2.2 times more abundant in infected patients than in non-infected ones. These results were verified and validated using PRM and ELISA immunoassays, which showed that infected patients had significantly higher concentrations of SAA1/2 than non-infected patients at hospital admission, but also at 1, 3, and 5 days after admission. CONCLUSIONS: The present study demonstrated that SAA1/2 is a promising predictor, at hospital admission, of stroke patients at risk of developing an infection. Further large, multicenter validation studies are needed to confirm these results. If confirmed, SAA1/2 concentrations could be used to identify the patients most at risk of post-stroke infections and therefore implement treatments more rapidly, thus reducing mortality

Trapped-ion decay spectroscopy towards the determination of ground-state components of double-beta decay matrix elements

A new technique has been developed at TRIUMF's TITAN facility to perform in-trap decay spectroscopy. The aim of this technique is to eventually measure weak electron capture branching ratios (ECBRs) and by this to consequently determine GT matrix elements of $\beta\beta$ decaying nuclei. These branching ratios provide important input to the theoretical description of these decays. The feasibility and power of the technique is demonstrated by measuring the ECBR of $^{124}$Cs.Comment: 9 pages, 9 figure

A cross-national study on the antecedents of work–life balance from the fit and balance perspective

Drawing on the perceived work–family fit and balance perspective, this study investigates demands and resources as antecedents of work–life balance (WLB) across four countries (New Zealand, France, Italy and Spain), so as to provide empirical cross-national evidence. Using structural equation modelling analysis on a sample of 870 full time employees, we found that work demands, hours worked and family demands were negatively related to WLB, while job autonomy and supervisor support were positively related to WLB. We also found evidence that resources (job autonomy and supervisor support) moderated the relationships between demands and work–life balance, with high resources consistently buffering any detrimental influence of demands on WLB. Furthermore, our study identified additional predictors of WLB that were unique to some national contexts. For example, in France and Italy, overtime hours worked were negatively associated with WLB, while parental status was positively associated with WLB. Overall, the implications for theory and practice are discussed.Peer ReviewedPostprint (author's final draft