824 research outputs found

    Line-of-Sight Reddening Predictions: Zero Points, Accuracies, the Interstellar Medium, and the Stellar Populations of Elliptical Galaxies

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    Revised (B-V)_0-Mg_2 data for 402 elliptical galaxies are given to test reddening predictions which can also tell us both what the intrinsic errors are in this relationship among gE galaxy stellar populations, as well as details of nearby structure in the interstellar medium (ISM) of our Galaxy and of the intrinsic errors in reddening predictions. Using least-squares fits, the explicit 1-sigma errors in the Burstein-Heiles (BH) and the Schlegel et al. (IR) predicted reddenings are calculated, as well as the 1-sigma observational error in the (B-V)_0-Mg_2 for gE galaxies. It is found that, in directions with E(B-V)<0.100 mag (where most of these galaxies lie), 1-sigma errors in the IR reddening predictions are 0.006 to 0.009 in E(B-V) mag, those for BH reddening prediction are 0.011 mag, and the 1-sigma agreement between the two reddening predictions is 0.007 mag. IR predictions have an accuracy of 0.010-0.011 mag in directions with E(B-V)>= 0.100 mag, significantly better than those of the BH predictions (0.024-0.025). Gas-to-dust variations that vary by a factor of 3, both high and low, exist along many lines-of-sight in our Galaxy. The approx 0.02 higher reddening zero point in E(B-V) previously determined by Schlegel et al. is confirmed, primarily at the Galactic poles. Despite this, both methods also predict many directions with E(B-V)<0.015 mag. Independent evidence of reddening at the North Galactic pole is reviewed, with the conclusion that there still exists directions at the NGP that have E(B-V)<<0.01. Two lines of evidence suggest that IR reddenings are overpredicted in directions with high gas-to-dust ratios. As high gas-to-dust directions in the ISM also include the Galactic poles, this overprediction is the likely cause of the E(B-V) = 0.02 mag larger IR reddening zero point.Comment: 5 figure

    Axon Regeneration in Young Adult Mice Lacking Nogo-A/B

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    AbstractAfter injury, axons of the adult mammalian brain and spinal cord exhibit little regeneration. It has been suggested that axon growth inhibitors, such as myelin-derived Nogo, prevent CNS axon repair. To investigate this hypothesis, we analyzed mice with a nogo mutation that eliminates Nogo-A/B expression. These mice are viable and exhibit normal locomotion. Corticospinal tract tracing reveals no abnormality in uninjured nogo-A/B−/− mice. After spinal cord injury, corticospinal axons of young adult nogo-A/B−/− mice sprout extensively rostral to a transection. Numerous fibers regenerate into distal cord segments of nogo-A/B−/− mice. Recovery of locomotor function is improved in these mice. Thus, Nogo-A plays a role in restricting axonal sprouting in the young adult CNS after injury

    Three-dimensional simulations of molecular cloud fragmentation regulated by magnetic fields and ambipolar diffusion

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    We employ the first fully three-dimensional simulation to study the role of magnetic fields and ion-neutral friction in regulating gravitationally-driven fragmentation of molecular clouds. The cores in an initially subcritical cloud develop gradually over an ambipolar diffusion time while the cores in an initially supercritical cloud develop in a dynamical time. The infall speeds on to cores are subsonic in the case of an initially subcritical cloud, while an extended (\ga 0.1 pc) region of supersonic infall exists in the case of an initially supercritical cloud. These results are consistent with previous two-dimensional simulations. We also found that a snapshot of the relation between density (rho) and the strength of the magnetic field (B) at different spatial points of the cloud coincides with the evolutionary track of an individual core. When the density becomes large, both relations tend to B \propto \rho^{0.5}.Comment: 8 pages, 11 figures, accepted for publication in MNRAS, a preprint with fine figures at http://yso.mtk.nao.ac.jp/~kudoh/publist_e.htm

    Apolipoprotein E and Alzheimer’s disease: The influence of apolipoprotein E on amyloid- and other amyloidogenic proteins

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    microRNAs and the evolution of complex multicellularity:Identification of a large, diverse complement of microRNAs in the brown alga Ectocarpus

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    There is currently convincing evidence that microRNAs have evolved independently in at least six different eukaryotic lineages: animals, land plants, chlorophyte green algae, demosponges, slime molds and brown algae. MicroRNAs from different lineages are not homologous but some structural features are strongly conserved across the eukaryotic tree allowing the application of stringent criteria to identify novel microRNA loci. A large set of 63 microRNA families was identified in the brown alga Ectocarpus based on mapping of RNA-seq data and nine microRNAs were confirmed by northern blotting. The Ectocarpus microRNAs are highly diverse at the sequence level with few multi-gene families, and do not tend to occur in clusters but exhibit some highly conserved structural features such as the presence of a uracil at the first residue. No homologues of Ectocarpus microRNAs were found in other stramenopile genomes indicating that they emerged late in stramenopile evolution and are perhaps specific to the brown algae. The large number of microRNA loci in Ectocarpus is consistent with the developmental complexity of many brown algal species and supports a proposed link between the emergence and expansion of microRNA regulatory systems and the evolution of complex multicellularity

    Comparing star formation models with interferometric observations of the protostar NGC 1333 IRAS 4A. I. Magnetohydrodynamic collapse models

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    Observations of dust polarized emission toward star forming regions trace the magnetic field component in the plane of the sky and provide constraints to theoretical models of cloud collapse. We compare high-angular resolution observations of the submillimeter polarized emission of the low-mass protostellar source NGC 1333 IRAS 4A with the predictions of three different models of collapse of magnetized molecular cloud cores. We compute the Stokes parameters for the dust emission for the three models. We then convolve the results with the instrumental response of the Submillimeter Array observation toward IRAS 4A. Finally, we compare the synthetic maps with the data, varying the model parameters and orientation, and we assess the quality of the fit by a \chi^2 analysis. High-angular resolution observations of polarized dust emission can constraint the physical properties of protostars. In the case of IRAS 4A, the best agreements with the data is obtained for models of collapse of clouds with mass-to-flux ratio >2 times the critical value, initial uniform magnetic field of strength ~0.5 mG, and age of the order of a few 10^4 yr since the onset of collapse. Magnetic dissipation, if present, is found to occur below the resolution level of the observations. Including a previously measured temperature profile of IRAS 4A leads to a more realistic morphology and intensity distribution. We also show that ALMA has the capability of distinguishing among the three different models adopted in this work. Our results are consistent with the standard theoretical scenario for the formation of low-mass stars, where clouds initially threaded by large-scale magnetic fields become unstable and collapse, trapping the field in the nascent protostar and the surrounding circumstellar disk. In the collapsing cloud, the dynamics is dominated by gravitational and magnetic forces.Comment: Accepted for publication in Astronomy And Astrophysics. 14 pages, 11 figures, 3 tables. Several the figures are shown at low resolutio

    Association of plasma and cortical beta-amyloid is modulated by APOE ε4 status.

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    Background: APOE ε4’s role as a modulator of the relationship between soluble plasma beta-amyloid (Aβ) and fibrillar brain Aβ measured by Pittsburgh Compound-B positron emission tomography ([11C]PiB PET) has not been assessed. Methods: Ninety-six Alzheimer’s Disease Neuroimaging Initiative participants with [11C]PiB scans and plasma Aβ1-40 and Aβ1-42 measurements at time of scan were included. Regional and voxel-wise analyses of [11C]PiB data were used to determine the influence of APOE ε4 on association of plasma Aβ1-40, Aβ1-42, and Aβ1-40/Aβ1-42 with [11C]PiB uptake. Results: In APOE ε4− but not ε4+ participants, positive relationships between plasma Aβ1-40/Aβ1-42 and [11C]PiB uptake were observed. Modeling the interaction of APOE and plasma Aβ1-40/Aβ1-42 improved the explained variance in [11C]PiB binding compared to using APOE and plasma Aβ1-40/Aβ1-42 as separate terms. Conclusions: The results suggest that plasma Aβ is a potential Alzheimer’s disease biomarker and highlight the importance of genetic variation in interpretation of plasma Aβ levels

    Comparative proteome analysis of propionate degradation by Syntrophobacter fumaroxidans in pure culture and in coculture with methanogens

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    Syntrophobacter fumaroxidans is a sulfatereducing bacterium able to grow on propionate axenically or in syntrophic interaction with methanogens or other sulfatereducing bacteria. We performed a proteome analysis of S. fumaroxidans growing with propionate axenically with sulfate or fumarate, and in syntrophy with Methanospirillum hungatei, Methanobacterium formicicum or Desulfovibrio desulfuricans. Special attention was put on the role of hydrogen and formate in interspecies electron transfer (IET) and energy conservation. Formate dehydrogenase Fdh1 and hydrogenase Hox were the main confurcating enzymes used for energy conservation. In the periplasm, Fdh2 and hydrogenase Hyn play an important role in reverse electron transport associated with succinate oxidation. Periplasmic Fdh3 and Fdh5 were involved in IET. The sulfate reduction pathway was poorly regulated and many enzymes associated with sulfate reduction (Sat, HppA, AprAB, DsrAB and DsrC) were abundant even at conditions where sulfate was not present. Proteins similar to heterodisulfide reductases (Hdr) were abundant. Hdr/Flox was detected in all conditions while HdrABC/HdrL was exclusively detected when sulfate was available; these complexes most likely confurcate electrons. Our results suggest that S. fumaroxidans mainly used formate for electron release and that different confurcating mechanisms were used in its sulfidogenic metabolism. This article is protected by copyrightThis research was supported by the Dutch Technology Foundation (STW) (project 11603), which is part of the Netherlands Organization for Scientific Research (NWO), and which is partly funded by the Ministry of Economic Affairs. Research of AJMS is supported by the European Research Council (ERC grant 323009) and the Gravitation grant (024.002.002) of the Netherlands Ministry of Education, Cultureand Science.info:eu-repo/semantics/publishedVersio

    Vertical-external-cavity surface-emitting lasers and quantum dot lasers

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    The use of cavity to manipulate photon emission of quantum dots (QDs) has been opening unprecedented opportunities for realizing quantum functional nanophotonic devices and also quantum information devices. In particular, in the field of semiconductor lasers, QDs were introduced as a superior alternative to quantum wells to suppress the temperature dependence of the threshold current in vertical-external-cavity surface-emitting lasers (VECSELs). In this work, a review of properties and development of semiconductor VECSEL devices and QD laser devices is given. Based on the features of VECSEL devices, the main emphasis is put on the recent development of technological approach on semiconductor QD VECSELs. Then, from the viewpoint of both single QD nanolaser and cavity quantum electrodynamics (QED), a single-QD-cavity system resulting from the strong coupling of QD cavity is presented. A difference of this review from the other existing works on semiconductor VECSEL devices is that we will cover both the fundamental aspects and technological approaches of QD VECSEL devices. And lastly, the presented review here has provided a deep insight into useful guideline for the development of QD VECSEL technology and future quantum functional nanophotonic devices and monolithic photonic integrated circuits (MPhICs).Comment: 21 pages, 4 figures. arXiv admin note: text overlap with arXiv:0904.369
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