Influence of convection and biomass burning outflow on tropospheric chemistry over the tropical Pacific

Observations over the tropics from the Pacific Exploratory Mission-Tropics A Experiment are analyzed using a one-dimensional model with an explicit formulation for convective transport. Adopting tropical convective mass fluxes from a general circulation model (GCM) yields a large discrepancy between observed and simulated CH3I concentrations. Observations of CH3I imply the convective mass outflux to be more evenly distributed with altitude over the tropical ocean than suggested by the GCM. We find that using a uniform convective turnover lifetime of 20 days in the upper and middle troposphere enables the model to reproduce CH3I observations. The model reproduces observed concentrations of H2O2 and CH3OOH. Convective transport of CH3OOH from the lower troposphere is estimated to account for 40-80% of CH3OOH concentrations in the upper troposphere. Photolysis of CH3OOH transported by convection more than doubles the primary HOx source and increases OH concentrations and O3 production by 10-50% and 0.4 ppbv d-1, respectively, above 11 km. Its effect on the OH concentration and O3 production integrated over the tropospheric column is, however, small. The effects of pollutant import from biomass burning regions are much more dominant. Using C2H2 as a tracer, we estimate that biomass burning outflow enhances O3 concentrations, O3 production, and concentrations of NOx and OH by 60%, 45%, 75%, and 7%, respectively. The model overestimates HNO3 concentrations by about a factor of 2 above 4 km for the upper one-third quantile of C2H2 data while it generally reproduces HNO3 concentrations for the lower and middle one-third quantiles of C2H2 data. Copyright 2000 by the American Geophysical Union

The Role of Simple Rules in the Conduct of Canadian Monetary Policy

The third strategy employed by the Bank when dealing with uncertainty is the consideration of appropriate simple reaction functions or "rules" for the setting of the policy interest rate. Since John Taylor's presentation of his much-discussed rule, research on simple policy rules has exploded. Simple rules have several advantages. In particular, they are easy to construct and communicate and are believed by some to be robust, in the sense of generating good results in a variety of economic models. This article provides an overview of the recent research regarding the usefulness and robustness of simple monetary policy rules, particularly in models of the Canadian economy. It also describes and explains the role of simple rules in the conduct of monetary policy in Canada.

Antitumor activity of epidermal growth factor receptor tyrosine kinase inhibitors in human hepatocellular carcinoma cell lines

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Allosteric Regulation Alters Carrier Domain Translocation in Pyruvate Carboxylase

Pyruvate carboxylase (PC) catalyzes the ATP-dependent carboxylation of pyruvate to oxaloacetate. The reaction occurs in two separate catalytic domains, coupled by the long-range translocation of a biotinylated carrier domain (BCCP). Here, we use a series of hybrid PC enzymes to examine multiple BCCP translocation pathways in PC. These studies reveal that the BCCP domain of PC adopts a wide range of translocation pathways during catalysis. Furthermore, the allosteric activator, acetyl CoA, promotes one specific intermolecular carrier domain translocation pathway. These results provide a basis for the ordered thermodynamic state and the enhanced carboxyl group transfer efficiency in the presence of acetyl CoA, and reveal that the allosteric effector regulates enzyme activity by altering carrier domain movement. Given the similarities with enzymes involved in the modular synthesis of natural products, the allosteric regulation of carrier domain movements in PC is likely to be broadly applicable to multiple important enzyme systems

Mitochondria directly influence fertilisation outcome in the pig

The mitochondrion is explicitly involved in cytoplasmic regulation and is the cell's major generator of ATP. Our aim was to determine whether mitochondria alone could influence fertilisation outcome. In vitro, oocyte competence can be assessed through the presence of glucose-6-phosphate dehydrogenase (G6PD) as indicated by the dye, brilliant cresyl blue (BCB). Using porcine in vitro fertilisation (IVF), we have assessed oocyte maturation, cytoplasmic volume, fertilisation outcome, mitochondrial number as determined by mtDNA copy number, and whether mitochondria are uniformly distributed between blastomeres of each embryo. After staining with BCB, we observed a significant difference in cytoplasmic volume between BCB positive (BCB+) and BCB negative (BCB-) oocytes. There was also a significant difference in mtDNA copy number between fertilised and unfertilised oocytes and unequal mitochondrial segregation between blastomeres during early cleavage stages. Furthermore, we have supplemented BCB- oocytes with mitochondria from maternal relatives and observed a significant difference in fertilisation outcomes following both IVF and intracytoplasmic sperm injection (ICSI) between supplemented, sham-injected and non-treated BCB- oocytes. We have therefore demonstrated a relationship between oocyte maturity, cytoplasmic volume, and fertilisation outcome and mitochondrial content. These data suggest that mitochondrial number is important for fertilisation outcome and embryonic development. Furthermore, a mitochondrial pre-fertilisation threshold may ensure that, as mitochondria are diluted out during post-fertilisation cleavage, there are sufficient copies of mtDNA per blastomere to allow transmission of mtDNA to each cell of the post-implantation embryo after the initiation of mtDNA replication during the early postimplantation stages

Mirror symmetric SU(3)-structure manifolds with NS fluxes

When string theory is compactified on a six-dimensional manifold with a nontrivial NS flux turned on, mirror symmetry exchanges the flux with a purely geometrical composite NS form associated with lack of integrability of the complex structure on the mirror side. Considering a general class of T^3-fibered geometries admitting SU(3) structure, we find an exchange of pure spinors (e^{iJ} and \Omega) in dual geometries under fiberwise T-duality, and study the transformations of the NS flux and the components of intrinsic torsion. A complementary study of action of twisted covariant derivatives on invariant spinors allows to extend our results to generic geometries and formulate a proposal for mirror symmetry in compactifications with NS flux.Comment: 21 pages, LaTe

Quadtree based mouse trajectory analysis for efficacy evaluation of voice-enabled CAD

Voice-enabled applications have caught considerable research interest in recent years. It is generally believed that voice based interactions can improve the working efficiencies and the overall productivities. Quantitative evaluations on the performance boost by using such Human-Computer interactions (HCI) are therefore necessary to justify the claimed efficacies and the usefulness of the HCI system. In this paper, a quadtree based approach is proposed to analyze the mouse movement distributions in the proposed Voice-enabled Computer-Aided Design (VeCAD) system. The mouse tracker keeps a record of all the mouse movement during the solid modeling process, and a quadtree based approach is applied to analyze the mouse trajectory distributions in both the traditional CAD and the VeCAD system. Our experiments show that the mouse movement is significantly reduced when voice is used to activate CAD modeling commands. ©2009 IEEE.published_or_final_versionThe IEEE International Conference on Virtual Environments, Human-Computer Interfaces, and Measurements Systems (VECIMS) 2009, Hong Kong, 11-13 May 2009. In Conference Proceedings, 2009, p. 196-20

Wilson's disease: A patient undiagnosed for 18 years

Wilson's disease, an autosomal recessive disorder of copper metabolism, is the most common inherited hepatic disease in Hong Kong. Diagnosis is based on the presence of Kayser-Fleischer rings, typical neurological symptoms, and/or a low serum ceruloplasmin concentration (<0.20 g/L). Early detection and treatment protect patients and their presymptomatic siblings from devastating organ damage. The diagnosis of Wilson's disease may nonetheless be overlooked if only established clinical and laboratory tests are used as diagnostic criteria. We report diagnosis of the disorder using genetic analysis of ATP7B in a presymptomatic sibling who escaped diagnosis during family screening 18 years previously. The patient was 11 months old when family screening was performed following diagnosis of Wilson's disease in an elder sister. The boy was considered to be unaffected on the basis of laboratory results in the expected range: serum copper level, 4.6 μmol/L; serum ceruloplasmin level, 0.16 g/L; and 24-hour urinary copper excretion, 0.14 μmol/day. Molecular analysis of ATP7B was performed; it revealed that the two siblings shared the same compound heterozygous mutations (G943D and 2299delC). We recommend that molecular diagnosis is the only definitive means of diagnosing Wilson's disease in children younger than 1 year.published_or_final_versio

Hypotensive action of diazepam in relation to age

Abstract no. 23published_or_final_versio