Greater trochanteric epiphysiodesis

In this paper, we wished to determine: (1) if a greater trochanteric epiphysiodesis (GTE) slows the growth of the greater trochanter; (2) if bone peg epiphysiodesis or screw epiphysiodesis is more effective at slowing greater trochanteric growth; and (3) if a GTE is most effective in young (<8 years) or older (>8) age. In this retrospective study, 35 children with unilateral Perthes disease underwent GTE. The height of the greater trochanter was measured radiographically at the time of surgery and at least two years after surgery. The untreated opposite side, which showed no radiographic evidence of Perthes disease, was used as a control. Epiphysiodesis was performed by using multiple drill holes and either a screw or a bone peg. Mean age at the time of surgery was 7 years (range, 3.2 to 12.2 years) and mean follow-up was 58 months (range, 24 to 104 months). We found that the growth of the greater trochanter that underwent epiphysiodesis was inhibited by 0.9 mm/year, as compared to the unaffected side (p = 0.007). Greater inhibition (1.8 mm/year) was noted in children who underwent a bone peg epiphysiodesis and also, surprisingly, in those over 8 years of age

Analgesic use - prevalence, biomonitoring and endocrine and reproductive effects

International audienceParacetamol and NSAIDs, in particular acetylsalicylic acid (aspirin) and ibuprofen, are among the most used and environmentally released pharmaceutical drugs. The differences in international trends in the sale and consumption of mild analgesics reflect differences in marketing, governmental policies, habits, accessibility, disease patterns and the age distribution of each population. Biomonitoring indicates ubiquitous and high human exposure to paracetamol and to salicylic acid, which is the main metabolite of acetylsalicylic acid. Furthermore, evidence suggests that analgesics can have endocrine disruptive properties capable of altering animal and human reproductive function from fetal life to adulthood in both sexes. Medical and public awareness about these health concerns should be increased, particularly among pregnant women