2,270 research outputs found
Immunoglobulin G4–related disease in Hong Kong: clinical features, treatment practices, and its association with multisystem disease
published_or_final_versio
Human papillomavirus status in southern Chinese women
1. The overall and type-specific human papillomavirus (HPV) prevalence differed between Hong Kong and Guangzhou healthy women. The prevalence of HPV was significantly higher in Guangzhou than Hong Kong women. Younger women had significantly higher risk of HPV infection. 2. HPV16 remained the most common type detected in both regions; the frequency increased with increasing disease severity. The prevalence of HPV58 and HPV52 was relatively high in women with normal cervix and precancerous lesions.published_or_final_versio
Overexpression of Forkhead Box Protein M1 (FOXM1) in Ovarian Cancer Correlates with Poor Patient Survival and Contributes to Paclitaxel Resistance
published_or_final_versio
Elizabethkingia anophelis bacteremia is associated with clinically significant infections and high mortality
published_or_final_versio
HPV infection and immunochemical detection of cell-cycle markers in verrucous carcinoma of the penis
Penile verrucous carcinoma is a rare disease and little is known of its aetiology or pathogenesis. In this study we examined cell-cycle proteins expression and correlation with human papillomavirus infection in a series of 15 pure penile verrucous carcinomas from a single centre. Of 148 penile tumours, 15 (10%) were diagnosed as pure verrucous carcinomas. The expression of the cell-cycle-associated proteins p53, p21, RB, p16INK4A and Ki67 were examined by immunohistochemistry. Human papillomavirus infection was determined by polymerase chain reaction to identify a wide range of virus types. The expression of p16INK4A and Ki67 was significantly lower in verrucous carcinoma than in usual type squamous cell carcinoma, whereas the expression of p53, p21 and RB was not significantly different. p53 showed basal expression in contrast to usual type squamous cell carcinoma. Human papillomavirus infection was present in only 3 out of 13 verrucous carcinomas. Unique low-risk, high-risk and mixed viral infections were observed in each of the three cases. In conclusion, lower levels of p16INK4A and Ki67 expressions differentiate penile verrucous carcinoma from usual type squamous cell carcinoma. The low Ki67 index reflects the slow-growing nature of verrucous tumours. The low level of p16INK4A expression and human papillomavirus detection suggests that penile verrucous carcinoma pathogenesis is unrelated to human papillomavirus infection and the oncogenes and tumour suppressor genes classically altered by virus infection.Peer reviewedFinal Accepted Versio
A consistent treatment for pion form factors in space-like and time-like regions
We write down some relevant matrix elements for the scattering and decay
processes of the pion by considering a quark-meson vertex function. The pion
charge and transition form factors , , and
are extracted from these matrix elements using a relativistic
quark model on the light-front. We found that, the form factors and
in the space-like region agree well with experiment.
Furthermore, the branching ratios of all observed decay modes of the neutral
pion, that are related to the form factors and
in the time-like region, are all consistent with the data as
well. Additionally, in the time-like region, which deals with the
nonvalence contribution, is also discussed.Comment: 24 pages, 6 figures, to appear in Phys. Rev.
A cross-national study on the antecedents of work–life balance from the fit and balance perspective
Drawing on the perceived work–family fit and balance perspective, this study investigates demands and resources as antecedents of work–life balance (WLB) across four countries (New Zealand, France, Italy and Spain), so as to provide empirical cross-national evidence. Using structural equation modelling analysis on a sample of 870 full time employees, we found that work demands, hours worked and family demands were negatively related to WLB, while job autonomy and supervisor support were positively related to WLB. We also found evidence that resources (job autonomy and supervisor support) moderated the relationships between demands and work–life balance, with high resources consistently buffering any detrimental influence of demands on WLB. Furthermore, our study identified additional predictors of WLB that were unique to some national contexts. For example, in France and Italy, overtime hours worked were negatively associated with WLB, while parental status was positively associated with WLB. Overall, the implications for theory and practice are discussed.Peer ReviewedPostprint (author's final draft
Development and Validation of the Behavioral Tendencies Questionnaire
At a fundamental level, taxonomy of behavior and behavioral tendencies can be described
in terms of approach, avoid, or equivocate (i.e., neither approach nor avoid). While there are
numerous theories of personality, temperament, and character, few seem to take advantage
of parsimonious taxonomy. The present study sought to implement this taxonomy by
creating a questionnaire based on a categorization of behavioral temperaments/tendencies
first identified in Buddhist accounts over fifteen hundred years ago. Items were developed
using historical and contemporary texts of the behavioral temperaments, described as
“Greedy/Faithful”, “Aversive/Discerning”, and “Deluded/Speculative”. To both maintain
this categorical typology and benefit from the advantageous properties of forced-choice
response format (e.g., reduction of response biases), binary pairwise preferences for items
were modeled using Latent Class Analysis (LCA). One sample (n1 = 394) was used to estimate
the item parameters, and the second sample (n2 = 504) was used to classify the participants
using the established parameters and cross-validate the classification against
multiple other measures. The cross-validated measure exhibited good nomothetic span
(construct-consistent relationships with related measures) that seemed to corroborate the
ideas present in the original Buddhist source documents. The final 13-block questionnaire
created from the best performing items (the Behavioral Tendencies Questionnaire or BTQ)
is a psychometrically valid questionnaire that is historically consistent, based in behavioral
tendencies, and promises practical and clinical utility particularly in settings that teach and
study meditation practices such as Mindfulness Based Stress Reduction (MBSR)
R-parity Conservation via the Stueckelberg Mechanism: LHC and Dark Matter Signals
We investigate the connection between the conservation of R-parity in
supersymmetry and the Stueckelberg mechanism for the mass generation of the B-L
vector gauge boson. It is shown that with universal boundary conditions for
soft terms of sfermions in each family at the high scale and with the
Stueckelberg mechanism for generating mass for the B-L gauge boson present in
the theory, electric charge conservation guarantees the conservation of
R-parity in the minimal B-L extended supersymmetric standard model. We also
discuss non-minimal extensions. This includes extensions where the gauge
symmetries arise with an additional U(1)_{B-L} x U(1)_X, where U(1)_X is a
hidden sector gauge group. In this case the presence of the additional U(1)_X
allows for a Z' gauge boson mass with B-L interactions to lie in the sub-TeV
region overcoming the multi-TeV LEP constraints. The possible tests of the
models at colliders and in dark matter experiments are analyzed including
signals of a low mass Z' resonance and the production of spin zero bosons and
their decays into two photons. In this model two types of dark matter
candidates emerge which are Majorana and Dirac particles. Predictions are made
for a possible simultaneous observation of new physics events in dark matter
experiments and at the LHC.Comment: 38 pages, 7 fig
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