Incidence of chemotherapy-induced amenorrhea associated with epirubicin, docetaxel and navelbine in younger breast cancer patients

<p>Abstract</p> <p>Background</p> <p>The rates of chemotherapy-induced amenorrhea (CIA) associated with docetaxel-based regimens reported by previous studies are discordant. For navelbine-based chemotherapies, rates of CIA have seldom been reported.</p> <p>Methods</p> <p>Of 170 premenopausal patients recruited between January 2003 and September 2008, 78 were treated with fluorouracil plus epirubicin and cyclophosphamide (FEC), 66 were treated with docetaxel plus epirubicin (TE), and 26 were treated with navelbine plus epirubicin (NE). Patient follow-up was carried up every 3-4 months during the first year, then every 9-12 months during subsequent years.</p> <p>Results</p> <p>In univariate analysis, the rates of CIA were 44.87% for the FEC regimen, 30.30% for the TE regimen and 23.08% for the NE regimen (<it>P </it>= 0.068). Significant differences in the rates of CIA were not found between the FEC and TE treatment groups (<it>P </it>> 0.05), but were found between the FEC and NE treatment groups (<it>P </it>< 0.05). Furthermore, no significant differences were found between the TE and NE regimens (<it>P </it>> 0.05). Tamoxifen use was a significant predictor for CIA (<it>P </it>= 0.001), and age was also a significant predictor (<it>P </it>< 0.001). In multivariate analysis, age (<it>P </it>< 0.001), the type of chemotherapy regimens (<it>P </it>= 0.009) and tamoxifen use (<it>P </it>= 0.003) were all significant predictors.</p> <p>Conclusions</p> <p>Age and administration of tamoxifen were found to be significant predictive factors of CIA, whereas docetaxel and navelbine based regimens were not associated with higher rates of CIA than epirubicin-based regimen.</p

The Moderating Effects of Parent Antisocial Characteristics on the Effects of Parent Management Training-Oregon (PMTO™)

Click on the DOI link below to access the article (may not be free).The degree to which parent antisocial characteristics moderated the effects of the Oregon model of Parent Management Training (PMTO (TM)) on observed parenting practices over 2 years after baseline was assessed in a sample of recently married biological mother and stepfather couples with at-risk children. Sixty-seven of the 110 participating families were randomly assigned to PMTO, and 43 families to a non-intervention condition. Using an intent-to-treat analysis, PMTO was reliably related to growth in positive parenting and to decreases in coercive parenting. Parent antisocial characteristics moderated the effect of PMTO on coercive but not on positive parenting practices. PMTO resulted in greater reductions in coercive parenting as parent antisocial histories were more extensive, and this moderator effect was found for both mothers and stepfathers. The findings support the effectiveness of PMTO as a preventive intervention for child conduct problems, and indicate that the ! parenting behaviors of antisocial parents are malleable and serve as important mediators of their impact on child conduct problems.Peer reviewe