The Discovery of Sgr A*

The compact radio source Sgr A* is associated with a 3.6 million black hole at the center of the Milky Way. The radio source was discovered in February 1974 by Bruce Balick and Robert L.Brown. The National Radio Astronomy Observatory's Green Bank 35 km radio link interferometer was used. We discuss other observations in the years 1965-1985 as well as early VLBI observations. The name Sgr A* was used for the first time in 1982 by Robert L.Brown and has become the accepted name in the intervening years.Comment: 8 pages,2 figures. Conference proceedings: "The central 300 parsecs of the Milky Way", editors A.Cotera, H.Falcke, T.R.Geballe, S.Markof

Rayleigh-Taylor Instabilities in Type Ia Supernova Remnants undergoing Cosmic-Ray Particle Acceleration - Low Adiabatic Index Solutions

This study investigates the evolution of Rayleigh-Taylor (R-T) instabilities in Type Ia supernova remnants that are associated with a low adiabatic index gamma, where gamma < 5/3, which reflects the expected change in the supernova shock structure as a result of cosmic-ray particle acceleration. Extreme cases, such as the case with the maximum compression ratio that corresponds to gamma=1.1, are examined. As gamma decreases, the shock compression ratio rises, and an increasingly narrow inter shock region with a more pronounced initial mixture of R-T unstable gas is produced. Consequently, the remnant outline may be perturbed by small-amplitude, small-wavelength bumps. However, as the instability decays over time, the extent of convective mixing in terms of the ratio of the radius of the R-T fingers to the blast wave does not strongly depend on the value of gamma for gamma >= 1.2. As a result of the age of the remnant, the unstable gas cannot extend sufficiently far to form metal-enriched filaments of ejecta material close to the periphery of Tycho's supernova remnant. The consistency of the dynamic properties of Tycho's remnant with the adiabatic model gamma=5/3 reveals that the injection of cosmic rays is too weak to alter the shock structure. Even with very efficient acceleration of cosmic rays at the shock, significantly enhanced mixing is not expected in Type Ia supernova remnants.Comment: 11 pages, 10 figures, MNRAS, accepte

High Energy Cosmic Rays From Supernovae

Cosmic rays are charged relativistic particles that reach the Earth with extremely high energies, providing striking evidence of the existence of effective accelerators in the Universe. Below an energy around $\sim 10^{17}$ eV cosmic rays are believed to be produced in the Milky Way while above that energy their origin is probably extragalactic. In the early '30s supernovae were already identified as possible sources for the Galactic component of cosmic rays. After the '70s this idea has gained more and more credibility thanks to the the development of the diffusive shock acceleration theory, which provides a robust theoretical framework for particle energization in astrophysical environments. Afterwards, mostly in recent years, much observational evidence has been gathered in support of this framework, converting a speculative idea in a real paradigm. In this Chapter the basic pillars of this paradigm will be illustrated. This includes the acceleration mechanism, the non linear effects produced by accelerated particles onto the shock dynamics needed to reach the highest energies, the escape process from the sources and the transportation of cosmic rays through the Galaxy. The theoretical picture will be corroborated by discussing several observations which support the idea that supernova remnants are effective cosmic ray factories.Comment: Final draft of a chapter in "Handbook of Supernovae" edited by Athem W. Alsabti and Paul Murdi

Jet-lag in Sgr A*: What size and timing measurements tell us about the central black hole in the Milky Way

The black hole at the Galactic Center, Sgr A*, is the prototype of a galactic nucleus at a very low level of activity. Its radio through submm-wave emission is known to come from a region close to the event horizon, however, the source of the emission is still under debate. A successful theory explaining the emission is based on a relativistic jet model scaled down from powerful quasars. We want to test the predictive power of this established jet model against newly available measurements of wavelength-dependent time lags and the size-wavelength structure in Sgr A*. Using all available closure amplitude VLBI data from different groups, we again derived the intrinsic wavelength-dependent size of Sgr A*. This allowed us to calculate the expected frequency-dependent time lags of radio flares, assuming a range of in- and outflow velocities. Moreover, we calculated the time lags expected in the previously published pressure-driven jet model. The predicted lags are then compared to radio monitoring observations at 22, 43, and 350 GHz. The combination of time lags and size measurements imply a mildly relativistic outflow with bulk outflow speeds of gamma*beta ~ 0.5-2. The newly measured time lags are reproduced well by the jet model without any major fine tuning. The results further strengthen the case for the cm-to-mm wave radio emission in Sgr A* as coming from a mildly relativistic jet-like outflow. The combination of radio time lag and VLBI closure amplitude measurements is a powerful new tool for assessing the flow speed and direction in Sgr A*. Future VLBI and time lag measurements over a range of wavelengths will reveal more information about Sgr A*, such as the existence of a jet nozzle, and measure the detailed velocity structure of a relativistic jet near its launching point for the first time.Comment: Latex, 7 pages, accepted for publication in Astronomy & Astrophysic

Extragalactic H_2O masers and X-ray absorbing column densities

Having conducted a search for the 22 GHz water vapor line towards galaxies with nuclear activity, large nuclear column densities or high infrared luminosities, we present H_2O spectra for NGC2273, UGC5101 and NGC3393 with isotropic luminosities of 7, 1500, and 400 L_sun. The H_2O maser in UGC5101 is by far the most luminous yet found in an ultraluminous infrared galaxy. NGC3393 reveals the classic spectrum of a `disk maser', represented by three distinct groups of Doppler components. As in all other known cases except NGC4258, the rotation velocity of the putative masing disk is well below 1000 km/s. Based on the literature and archive data, X-ray absorbing column densities are compiled for the 64 galaxies with reported maser sources beyond the Magellanic Clouds. For NGC2782 and NGC5728, we present Chandra archive data that indicate the presence of an active galactic nucleus in both galaxies. The correlation between absorbing column and H_2O emission is analyzed. There is a striking difference between kilo- and megamasers with megamasers being associated with higher column densities. All kilomasers (L_H_2O < 10 L_sun) except NGC2273 and NGC5194 are Compton-thin, i.e. their absorbing columns are < 10^24 cm^-2. Among the H_2O megamasers, 50% arise from Compton-thick and 85% from heavily obscured (> 10^23 cm^-2) active galactic nuclei. These values are not larger but consistent with those from samples of Seyfert 2 galaxies not selected on the basis of maser emission. The similarity in column densities can be explained by small deviations in position between maser spots and nuclear X-ray source and a high degree of clumpiness in the circumnuclear interstellar medium.Comment: 16 pages, 7 figures, 5 tables. Accepted for publication in A&

WNT signaling regulates self-renewal and differentiation of prostate cancer cells with stem cell characteristics

Prostate cancer cells with stem cell characteristics were identified in human prostate cancer cell lines by their ability to form from single cells self-renewing prostaspheres in non-adherent cultures. Prostaspheres exhibited heterogeneous expression of proliferation, differentiation and stem cell-associated makers CD44, ABCG2 and CD133. Treatment with WNT inhibitors reduced both prostasphere size and self-renewal. In contrast, addition of Wnt3a caused increased prostasphere size and self-renewal, which was associated with a significant increase in nuclear Β-catenin, keratin 18, CD133 and CD44 expression. As a high proportion of LNCaP and C4-2B cancer cells express androgen receptor we determined the effect of the androgen receptor antagonist bicalutamide. Androgen receptor inhibition reduced prostasphere size and expression of PSA, but did not inhibit prostasphere formation. These effects are consistent with the androgen-independent self-renewal of cells with stem cell characteristics and the androgen-dependent proliferation of transit amplifying cells. As the canonical WNT signaling effector Β-catenin can also associate with the androgen receptor, we propose a model for tumour propagation involving a balance between WNT and androgen receptor activity. That would affect the self-renewal of a cancer cell with stem cell characteristics and drive transit amplifying cell proliferation and differentiation. In conclusion, we provide evidence that WNT activity regulates the self-renewal of prostate cancer cells with stem cell characteristics independently of androgen receptor activity. Inhibition of WNT signaling therefore has the potential to reduce the self-renewal of prostate cancer cells with stem cell characteristics and improve the therapeutic outcome.Peer reviewe

Maternal Work and Children’s Development. Examining 20 Years of Evidence

Maternal work may affect children positively through increased household income, higher control of mothers over available income, and expansion of maternal information networks through work contacts and greater decision-making power of mothers as they become more economically empowered. However, maternal work may reduce maternal time spent with children. If maternal time is not substituted for time of equal quality by other caregivers, children’s development may be penalized. Stress associated with work may also decrease the quality of parenting. This review summarizes causal evidence on the relationship between maternal work and children’s development. The majority causal studies find positive or null impacts of maternal work on children’s development

Gravitational Lensing by Black Holes

We review the theoretical aspects of gravitational lensing by black holes, and discuss the perspectives for realistic observations. We will first treat lensing by spherically symmetric black holes, in which the formation of infinite sequences of higher order images emerges in the clearest way. We will then consider the effects of the spin of the black hole, with the formation of giant higher order caustics and multiple images. Finally, we will consider the perspectives for observations of black hole lensing, from the detection of secondary images of stellar sources and spots on the accretion disk to the interpretation of iron K-lines and direct imaging of the shadow of the black hole.Comment: Invited article for the GRG special issue on lensing (P. Jetzer, Y. Mellier and V. Perlick Eds.). 31 pages, 12 figure

Deletion of the GABAA α2-subunit does not alter self dministration of cocaine or reinstatement of cocaine seeking

Rationale GABAA receptors containing α2-subunits are highly represented in brain areas that are involved in motivation and reward, and have been associated with addiction to several drugs, including cocaine. We have shown previously that a deletion of the α2-subunit results in an absence of sensitisation to cocaine. Objective We investigated the reinforcing properties of cocaine in GABAA α2-subunit knockout (KO) mice using an intravenous self-administration procedure. Methods α2-subunit wildtype (WT), heterozygous (HT) and KO mice were trained to lever press for a 30 % condensed milk solution. After implantation with a jugular catheter, mice were trained to lever press for cocaine (0.5 mg/kg/infusion) during ten daily sessions. Responding was extinguished and the mice tested for cue- and cocaine-primed reinstatement. Separate groups of mice were trained to respond for decreasing doses of cocaine (0.25, 0.125, 0.06 and 0.03 mg/kg). Results No differences were found in acquisition of lever pressing for milk. All genotypes acquired self-administration of cocaine and did not differ in rates of self-administration, dose dependency or reinstatement. However, whilst WT and HT mice showed a dose-dependent increase in lever pressing during the cue presentation, KO mice did not. Conclusions Despite a reported absence of sensitisation, motivation to obtain cocaine remains unchanged in KO and HT mice. Reinstatement of cocaine seeking by cocaine and cocaine-paired cues is also unaffected. We postulate that whilst not directly involved in reward perception, the α2-subunit may be involved in modulating the “energising” aspect of cocaine’s effects on reward-seeking

Measurement of the cross-section and charge asymmetry of WW bosons produced in proton-proton collisions at s=8\sqrt{s}=8 TeV with the ATLAS detector

This paper presents measurements of the $W^+ \rightarrow \mu^+\nu$ and $W^- \rightarrow \mu^-\nu$ cross-sections and the associated charge asymmetry as a function of the absolute pseudorapidity of the decay muon. The data were collected in proton--proton collisions at a centre-of-mass energy of 8 TeV with the ATLAS experiment at the LHC and correspond to a total integrated luminosity of 20.2~\mbox{fb^{-1}}. The precision of the cross-section measurements varies between 0.8% to 1.5% as a function of the pseudorapidity, excluding the 1.9% uncertainty on the integrated luminosity. The charge asymmetry is measured with an uncertainty between 0.002 and 0.003. The results are compared with predictions based on next-to-next-to-leading-order calculations with various parton distribution functions and have the sensitivity to discriminate between them.Comment: 38 pages in total, author list starting page 22, 5 figures, 4 tables, submitted to EPJC. All figures including auxiliary figures are available at https://atlas.web.cern.ch/Atlas/GROUPS/PHYSICS/PAPERS/STDM-2017-13