Explicit minimal Scherk saddle towers of arbitrary even genera in R3\R^3

Starting from works by Scherk (1835) and by Enneper-Weierstra\ss \ (1863), new minimal surfaces with Scherk ends were found only in 1988 by Karcher (see \cite{Karcher1,Karcher}). In the singly periodic case, Karcher's examples of positive genera had been unique until Traizet obtained new ones in 1996 (see \cite{Traizet}). However, Traizet's construction is implicit and excludes {\it towers}, namely the desingularisation of more than two concurrent planes. Then, new explicit towers were found only in 2006 by Martin and Ramos Batista (see \cite{Martin}), all of them with genus one. For genus two, the first such towers were constructed in 2010 (see \cite{Valerio2}). Back to 2009, implicit towers of arbitrary genera were found in \cite{HMM}. In our present work we obtain {\it explicit} minimal Scherk saddle towers, for any given genus $2k$, $k\ge3$

Caveolin-1 is a risk factor for postsurgery metastasis in preclinical melanoma models

Melanomas are highly lethal skin tumours that are frequently treated by surgical resection. However, the efficacy of such procedures is often limited by tumour recurrence and metastasis. Caveolin-1 (CAV1) has been attributed roles as a tumour suppressor, although in late-stage tumours, its presence is associated with enhanced metastasis. The expression of this protein in human melanoma development and particularly how the presence of CAV1 affects metastasis after surgery has not been defined. CAV1 expression in human melanocytes and melanomas increases with disease progression and is highest in metastatic melanomas. The effect of increased CAV1 expression can then be evaluated using B16F10 murine melanoma cells injected into syngenic immunocompetent C57BL/6 mice or human A375 melanoma cells injected into immunodeficient B6Rag1−/− mice. Augmented CAV1 expression suppresses tumour formation upon a subcutaneous injection, but enhances lung metastasis of cells injected into the tail vein in both models. A procedure was initially developed using B16F10 melanoma cells in C57BL/6 mice to mimic better the situation in patients undergoing surgery. Subcutaneous tumours of a defined size were removed surgically and local tumour recurrence and lung metastasis were evaluated after another 14 days. In this postsurgery setting, CAV1 presence in B16F10 melanomas favoured metastasis to the lung, although tumour suppression at the initial site was still evident. Similar results were obtained when evaluating A375 cells in B6Rag1−/− mice. These results implicate CAV1 expression in melanomas as a marker of poor prognosis for patients undergoing surgery as CAV1 expression promotes experimental lung metastasis in two different preclinical models

Dissipation-driven superconductor-insulator transition in linear arrays of Josephson junctions capacitively coupled to metallic films

We study the low-temperature properties of linear Josephson-junction arrays capacitively coupled to a proximate two-dimensional diffusive metal. Using bosonization techniques, we derive an effective model for the array and obtain its critical properties and phases at T = 0 using a renormalization group analysis and a variational approach. While static screening effects given by the presence of the metal can be absorbed in a renormalization of the parameters of the array, backscattering originated in the dynamically screened Coulomb interaction produces a non-trivial stabilization of the insulating groundstate and can drive a superconductor-insulator transition. We study the consequences for the transport properties in the low-temperature regime. In particular, we calculate the resisitivity as a function of the temperature and the parameters of the array, and obtain clear signatures of a superconductor-insulator transition that could be observed in experiments.Comment: 10 pages, 5 figures, submitted to Physical Review

Experience-Based Dialogues in Secondary English-as-a-Second-Language Classrooms

An informal study was conducted to explore the effectiveness of experience-based dialogues in the promotion of oral language use in secondary-level English-As-A-Second-Language classrooms. The twenty-one dialogues field-tested in the project were developed interactively, by teacher and students, in the sociocognitive context of each of the learner\u27s background knowledge, experience and immediate communication needs. Experience-based dialogues are a method of language teaching and learning that focuses on the communicative act rather than on isolated or discrete grammatical items. An overview of the results of the informal study was presented here. Strategies for teachers to develop and implement, using this approach, were also discussed

Crystal-field effects in the mixed-valence compounds Yb2M3Ga9 (M= Rh, Ir)

Magnetic susceptibility, heat capacity, and electrical resistivity measurements have been carried out on single crystals of the intermediate valence compounds Yb2Rh3Ga9 and Yb2Ir3Ga9. These measurements reveal a large anisotropy due apparently to an interplay between crystalline electric field (CEF) and Kondo effects. The temperature dependence of magnetic susceptibility can be modelled using the Anderson impurity model including CEF within an approach based on the Non-Crossing Approximation.Comment: Accepted to Phys. Rev.

The Caveolin-1 Connection to Cell Death and Survival

Nunez, S (Nunez, S.)[ 1,4 ] 1. Fac Med, CEMC, Lab Comunicac Celulares, Santiago, Chile. 4. Univ Talca, Fac Hlth Sci, Talca, ChileCaveolins are a family of membrane proteins required for the formation of small plasma membrane invaginations called caveolae that are implicated in cellular trafficking processes. In addition to this structural role, these scaffolding proteins modulate numerous intracellular signaling pathways; often via direct interaction with specific binding partners. Caveolin-1 is particularly well-studied in this respect and has been attributed a large variety of functions. Thus, Caveolin-1 also represents the best-characterized isoform of this family with respect to its participation in cancer. Rather strikingly, available evidence indicates that Caveolin-1 belongs to a select group of proteins that function, depending on the cellular settings, both as tumor suppressor and promoter of cellular traits commonly associated with enhanced malignant behavior, such as metastasis and multi-drug resistance. The mechanisms underlying such ambiguity in Caveolin-1 function constitute an area of great interest. Here, we will focus on discussing how Caveolin-1 modulates cell death and survival pathways and how this may contribute to a better understanding of the ambiguous role this protein plays in cancer

a multi-centre cross-country comparison of women in management and leadership in academic health centres in the European Union

Background Women’s participation in medicine and the need for gender equality in healthcare are increasingly recognised, yet little attention is paid to leadership and management positions in large publicly funded academic health centres. This study illustrates such a need, taking the case of four large European centres: Charité – Universitätsmedizin Berlin (Germany), Karolinska Institutet (Sweden), Medizinische Universität Wien (Austria), and Oxford Academic Health Science Centre (United Kingdom). Case The percentage of female medical students and doctors in all four countries is now well within the 40–60% gender balance zone. Women are less well represented among specialists and remain significantly under-represented among senior doctors and full professors. All four centres have made progress in closing the gender leadership gap on boards and other top-level decision-making bodies, but a gender leadership gap remains relevant. The level of achieved gender balance varies significantly between the centres and largely mirrors country-specific welfare state models, with more equal gender relations in Sweden than in the other countries. Notably, there are also similar trends across countries and centres: gender inequality is stronger within academic enterprises than within hospital enterprises and stronger in middle management than at the top level. These novel findings reveal fissures in the ‘glass ceiling’ effects at top- level management, while the barriers for women shift to middle-level management and remain strong in academic positions. The uneven shifts in the leadership gap are highly relevant and have policy implications. Conclusion Setting gender balance objectives exclusively for top-level decision-making bodies may not effectively promote a wider goal of gender equality. Academic health centres should pay greater attention to gender equality as an issue of organisational performance and good leadership at all levels of management, with particular attention to academic enterprises and newly created management structures. Developing comprehensive gender-sensitive health workforce monitoring systems and comparing progress across academic health centres in Europe could help to identify the gender leadership gap and utilise health human resources more effectively