Quiet Riot

Isadora Duncan and Martha Graham have long been revered as leaders in propelling modern dance forward. Because their techniques were both built out of their need to express their struggles with their current social norms, their versions of modern dance can be seen as embodied feminism. Modern dance was born as a rebellion against ballet, and the restrictive elements of that technique. Well known for freeing the torso, Isadora Duncan based her technique off of naturalistic movement. Martha Graham’s technique comes from a focus on breath that evolved into contraction and release, which is the contraction of the spine that releases into a flat back. The theater piece that I created was a connection between the work of those two women and feminism. The piece was also an expansion of the exploration of using the physicality of modern dance to embody elements of feminism

Sex in the Kitchen: The Re-interpretation of Gendered Space Within the Post-World War II Suburban Home in the West

In the decades following 1945, Americans moved increasingly out of cities into suburbs. The migration illustrated the emergence of a new, broader middle class as a result of growing postwar affluence. In the previous half-century, families living in a suburb could claim middle-class status. The emerging class built its identity on the forms and values adopted from this earlier, more affluent Victorian middle class. These adopted values were played out in a home designed around Progressive era ideals of the family. Through this Progressive filter, the new concept of the home was scaled down, without servants, and ceased existing wholly as the wife\u27s sphere of influence--as in the Victorian version. The Progressive impulse also reduced the size of the house to make it more efficient, and through government subsidies shaped the home into a smaller, economically sized package. The financial framework that determined the shape of the postwar home also influenced the technology placed within its walls. This financially influenced technology particularly affected the shape and content of the kitchen. The new, efficient kitchen did not release women from their duty to provide daily family meals, but it did create a culturally safe space for men to cook as a hobby. In the postwar, suburban kitchen women and men contended with economic pressures and changing social realities which complicated the Victorian values and Progressive ideals. Middle-class women needed to leave the home for work, and--now separated from traditional urban social outlets--middle-class men sought refuge in the suburban home. By examining Sunset magazine\u27s Chefs of the West column, traditional women\u27s cookbooks and service magazines, men\u27s magazines, building industry trade journals, and census reports, the kitchen demonstrates that women and men reshaped the home in response to changing middle-class values. While financing regulations at first shaped how the emerging middle class lived within the postwar, suburban home, residents reinterpreted the space as a reaction to the economic changes around them. This cycle continued with each new interpretation of the postwar single-family home

A follow-up study of the business department graduates of Hampton Institute from 1947 to 1950

Thesis (Ed. M.)--Boston University, 195

Evidence for the presence of A1 adenosine receptors in the aorta of spontaneously hypertensive rats

1 Isolated aortic rings (endothelium-intact and -denuded) from spontaneously hypertensive (SHR) and Wistar-Kyoto (WKY) rats were used in this study to examine the vasoactive e ects of various adenosine analogues. 2 In phenylephrine contracted aortic rings, concentration-response curves were constructed by cumulative additions (10711 ±1075 M) of (2S)-N6-[2-endo-Norbornyl] adenosine (ENBA), N6- cyclopentyladenosine (CPA), R-N6-(2-phenylisopropyl) adenosine (R-PIA), 2-p-(-2-carboxyethyl) phenethylamino-5'-N-thylcarboxamido adenosine (CGS-21680). 3 A non-speci®c adenosine receptor agonist 2-chloroadenosine (CAD) resulted in biphasic response with a small contraction at lower concentrations (1079 ±1078 M) followed by a signi®cant relaxation at higher concentration in endothelium-intact SHR tissues, suggesting presence of both A1 and A2 adenosine receptors in SHR aorta. However, only relaxation was observed in WKY. 4 Contractile response in SHR had the following rank order of potency: ENBA4CPA4R- PIA4CAD. The relaxation response in SHR and WKY had the following rank order of potency: CGS 216804CAD4R-PIA4CPA4ENBA. 5 Removal of endothelium abolished the adenosine analogue induced contractions in SHR aorta and attenuated the vasorelaxation responses in the WKY and SHR. 6 The contractile response in SHR was abolished by A1 adenosine receptor antagonist N6- endonorbornan-2-yl-9-methyladenine (N-0861). A2 adenosine receptor antagonist, 3,7-dimethyl-1-proparglyxanthine (DMPX) did not a ect the contraction response of adenosine analogues. 7 Endothelium-dependent contractions elicited by A1 receptor agonists were blocked by indomethacin and by free radical scavengers. 8 These data suggest that the contractile response to adenosine analogues in SHR aorta is probably mediated by free radicals which are generated through the increased cyclo-oxygenase activity occurring in the vascular endothelium of SHR but not the WKY rats. British Journal of Pharmacology (2001) 134, 1760 ± 1766. Originally published British Journal of Pharmacology, Vol. 134, No. 8, Dec 200

Cardiovascular Interoceptive Accuracy Correlates with Piezo 1 Mediated Baroreceptor Sensitivity and State Anxiety: Implications for Hypoglycemic Awareness

CARDIOVASCULAR INTEROCEPTIVE ACCURACY CORRELATES WITH PIEZO 1 MEDIATED BARORE- CEPTOR SENSITIVITY AND STATE ANXIETY: IMPLICATIONS FOR HYPOGLYCEMIC AWARENESS. Jack Summers, B.S., Zachary Miklja, M.D., Warren Lockette, M.D., Wayne State University School of Medicine, Detroit, Ml, USA. Background: There is a brisk, reflex autonomic response to low blood glucose in which surges of catecholamines are released to enhance glycogenolysis, gluconeogenesis, and lipolysis. In addition to providing metabolic substrates, the cardiovascular responses to this surge in norepinephrine and epinephrine include an increase in heart rate and cardiac contractility. How these changes in heart rate and contractility are subjectively sensed and perceived as hypoglycemia is unknown. Exteroceptive sensors (e.g. visual and auditory receptors) allow us to respond to external threats from the environment. Interoceptive sensory receptors allow us to identify threats within the internal milieu, but their nature is unknown. Teleologically, interoceptive cues can serve as a warning as humans perceive changes in their heart rate or rhythm (“my heart skipped a beat”) brought about by stressors such as hypoglycemia or pain. Hypothesis: We propose that Piezo 1 channels in the heart of men and women are responsible for cardiac interoception. Because Piezo 1 channels mediate baroreceptor sensitivity, we postulated awareness of stress-induced increases in heart rate (i.e. cardiac interoceptive accuracy, “IA”) would correlate with changes in an individual’s heart rate and pulse pressure. Furthermore, those individuals with greater IA would have greater behavioral state anxiety. Finally, we expected that ex vivo measurements of Piezo 1 sensitivity could be used to predict an individual’s IA and state anxiety levels. Methods: We recruited 21 healthy men and women in whom IA was measured with a heartbeat detection task. We used the cold pressor test as our surrogate stressor to obviate the need to induce untoward hypoglycemia. Hemodynamics were measured non- invasively before and during a cold (1o C) pressor test over three minutes. State anxiety was assessed with a validated questionnaire. Piezo 1 channel activity was measured using a hypotonicity lysis assay on erythrocytes from our volunteers. Results: An increase in IA was inversely correlated with baroreceptor sensitivity as determined by the change in heart rate induced by cold pressor test-induced increases in pulse pressure, Spearman’s r = -0.58, p = 0.0056. IA also correlated positively with state anxiety, Spearman’s r = 0.52, p = 0. 042. Finally, our ex vivo assay demonstrated that erythrocyte Piezo1 channel sensitivity also correlated with state anxiety, Spearman’s r = 0.72, p = 0.016. Conclusions: Individual variations in Piezo 1 channel activity could explain individual differences in the subjective sensing of cardiovascular and subjective behavioral responses to physiological stressors such as hypoglycemia. Our ex vivo assay of Piezo1 sensitivity could identify those individuals predisposed to impaired awareness of hypoglycemia

The Metabolic Syndrome: A Modern Plague Spread by Modern Technology

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/73419/1/j.1751-7176.2009.00191.x.pd

Investigating rare genetic variants of unknown significance in LDHA

The exponential expansion and advancement of genetic sequencing has revealed the molecular basis of many genetic diseases. However, many genetic mutations are still classified as variants of unknown significance (VUS). Our lab focused on eleven missense variants in Lactate Dehydrogenase A (LDHA), an enzyme vital in anaerobic respiration. The intent with our research is to produce data on the kinetic functionality of wild type LDHA and compare this to its mutants of unknown significance. This data, supplemented with the structural information of the mutants can help reduce the ambiguity in the diagnosis of genetic disorders involving the LDHA enzyme. Currently, we have recorded the baseline kinetic function of the wild type LDHA based on its ability to convert the coenzyme NADH to NAD+. While we have a general understanding of the kinetic function of our mutant variants, A320T, T309P, L190F, E55K, D46V, P139L, G282R, K119R, T95M, G103E, and I94F, further tests need to be conducted to reduce variability

Integrating Design Throughout The Mechanical Engineering Curriculum: A Focus On The Engineering Clinics

At Rowan University, we have infused design into the curriculum through an eight-semester course sequence called the Engineering Clinic. Through this experience students learn the art and science of design in a multidisciplinary team environment. While many engineering programs currently include a Capstone Design course taken near the end of the college career to meet the design needs, Engineering Clinic at Rowan allows students to hone their design skills throughout their four-year career. This paper will describe in further detail the objectives and execution of each year in the design sequence, types of projects and how the Clinics complement traditional core courses in the curriculum. Impacts and benefits of the Clinics on students and faculty are discussed, as well as comparative data of Rowan Mechanical Engineering students and their peers nationally

Endothelial dysfunction and vascular disease

The endothelium can evoke relaxations (dilatations) of the underlying vascular smooth muscle, by releasing vasodilator substances. The best characterized endothelium-derived relaxing factor (EDRF) is nitric oxide (NO). The endothelial cells also evoke hyperpolarization of the cell membrane of vascular smooth muscle (endothelium-dependent hyperpolarizations, EDHF-mediated responses). Endothelium-dependent relaxations involve both pertussis toxin-sensitive G i (e.g. responses to serotonin and thrombin) and pertussis toxin-insensitive G q (e.g. adenosine diphosphate and bradykinin) coupling proteins. The release of NO by the endothelial cell can be up-regulated (e.g. by oestrogens, exercise and dietary factors) and down-regulated (e.g. oxidative stress, smoking and oxidized low-density lipoproteins). It is reduced in the course of vascular disease (e.g. diabetes and hypertension). Arteries covered with regenerated endothelium (e.g. following angioplasty) selectively loose the pertussis toxin-sensitive pathway for NO release which favours vasospasm, thrombosis, penetration of macrophages, cellular growth and the inflammatory reaction leading to atherosclerosis. In addition to the release of NO (and causing endothelium-dependent hyperpolarizations), endothelial cells also can evoke contraction (constriction) of the underlying vascular smooth muscle cells by releasing endothelium-derived contracting factor (EDCF). Most endothelium-dependent acute increases in contractile force are due to the formation of vasoconstrictor prostanoids (endoperoxides and prostacyclin) which activate TP receptors of the vascular smooth muscle cells. EDCF-mediated responses are exacerbated when the production of NO is impaired (e.g. by oxidative stress, ageing, spontaneous hypertension and diabetes). They contribute to the blunting of endothelium-dependent vasodilatations in aged subjects and essential hypertensive patients. © 2008 Scandinavian Physiological Society.postprin

Effect of ketorolac and diclofenac on the impairment of endothelium-dependent relaxation induced by reactive oxygen species in rabbit abdominal aorta

Background: Reactive oxygen species (ROS) induce lipid peroxidation and tissue damage in endothelium. We studied the influences of ketorolac and diclofenac on ROS effects using the endothelium of rabbit abdominal aorta. Methods: Isolated rabbit aortic rings were suspended in an organ bath filled with Krebs-Henseleit (K-H) solution bubbled with 5% CO2 and 95% O2 at 37.5??C. After being stimulated to contract with phenylephrine (PE, 10-6 M), changes in arterial tension were recorded following the cumulative administration of acetylcholine (ACh, 3 ?? 10-8 to 10-6 M). The percentages of ACh-induced relaxation of aortic rings before and after exposure to ROS, generated by electrolysis of K-H solution, were used as the control and experimental values, respectively. The aortic rings were pretreated with ketorolac or diclofenac at the same concentrations (10-5 M to 3 ?? 10-4 M), and the effects of these agents were compared with the effects of ROS scavengers: catalase, mannitol, sodium salicylate and deferoxamine and the catalase inhibitor, 3-amino-1,2,4-triazole (3AT). Results: Both ketorolac and diclofenac maintained endothlium-dependent relaxation induced by ACh in a dose-related manner inspite of ROS attack (P < 0.05 vs. control value). The 3AT pretreated ketorolac (3 ?? 10-3 M) group was decreased more significantly than un-pretreated ketorolac (P < 0.05). Conclusions: These findings suggest that ketorlac and diclofenac preserve the endothelium-dependent vasorelaxation against the attack of ROS, in a concentration-related manner. One of the endothelial protection mechanisms of ketorolac may be hydrogen peroxide scavenging. Copyright ?? Korean Society of Anesthesiologists, 2010