Pflanzen für die Gesundheit-Vorstellung eines neuen interdisziplinären Forschungsprojektes zum ökologischen Anbau von Arzneipflanzen

Ecologically grown medicinal plants containing bioactive compounds hold great poten-tial as high-value niche crops for farmers. However, the way to grow these plants differs from traditional crops. Growing techniques, harvest methods and postharvest handling of the raw material plays a crucial role regarding the quality of the raw material that the farmers can offer. The purpose of a new research project financed by EU-Interreg IIIA programme is among other things to carry out production, harvest and processing experiments with plants containing bioactive plant compounds that hold a preventive effect toward diabetes II. One of the project´s goals is to draw up cultivation instructions for the primary producers to use when cultivating the plants in question. Examples of the plants that are being examined in the project are Goat´s Rue (Galega officinalis) and Fenugreek (Trigonella foenum-graecum)

ARTEMIN Promotes De Novo Angiogenesis in ER Negative Mammary Carcinoma through Activation of TWIST1-VEGF-A Signalling

10.1371/journal.pone.0050098PLoS ONE711

Effects of Soil and Foliar Applied Fertilizers on Growth, Yield and Sugar Quality of Two Sugarcane Cultivars under Rainfed Conditions

Background: In north-eastern Thailand, sugarcane is planted normally in late rainy season wherein the plants may experience drought stress during its early growth stage in dry season and waterlogging stress during late growth stage at peak of rainy season. Hence, the objective of the present study was to investigate the effects of soil application alone and soil combined with foliar application of nutrients on growth, yield and sugar quality of sugarcane grown under rainfed conditions. Methods: The field experiment was conducted during November 2016 to December 2017. A split-plot design with three replications was laid out. The two sugarcane cultivars (KK3, K93-219) were assigned as main plots. The fertilizer application methods were assigned as sub-plots that comprised of four treatments: (1) soil applied NPK, (2) soil NPK + foliar N and K applied at 90 days after planting (DAP), (3) soil NPK + foliar N and K applied at 210 DAP and (4) soil NPK + foliar N and K applied at 90 and 210 DAP. Result: The soil NPK + foliar N and K applied at 90 and 210 DAP improved yield components and cane yield. The cultivar K93-219 produced significantly higher cane yield than KK3. The fertilizer application methods and cultivars had no significant effect on sugar quality such as brix (%), purity (%), polarity (%), fiber (%) and commercial cane sugar (CCS-%)

Nutrição.

O antúrio é uma planta típica de florestas tropicais. As diversas quer sobre troncos de grandes árvores, quer sobre a matéria orgânica depositada no solo da mata, pois suas raízes aéreas têm grande capacidade de absorverem nutrientes e água e exploram apenas as partes ao substrato

DNAAF1 links heart laterality with the AAA+ ATPase RUVBL1 and ciliary intraflagellar transport

DNAAF1 (LRRC50) is a cytoplasmic protein required for dynein heavy chain assembly and cilia motility, and DNAAF1 mutations cause primary ciliary dyskinesia (PCD; MIM 613193). We describe four families with DNAAF1 mutations and complex congenital heart disease (CHD). In three families, all affected individuals have typical PCD phenotypes. However, an additional family demonstrates isolated CHD (heterotaxy) in two affected siblings, but no clinical evidence of PCD. We identified a homozygous DNAAF1 missense mutation, p.Leu191Phe, as causative for heterotaxy in this family. Genetic complementation in dnaaf1-null zebrafish embryos demonstrated the rescue of normal heart looping with wild-type human DNAAF1, but not the p.Leu191Phe variant, supporting the conserved pathogenicity of this DNAAF1 missense mutation. This observation points to a phenotypic continuum between CHD and PCD, providing new insights into the pathogenesis of isolated CHD. In further investigations of the function of DNAAF1 in dynein arm assembly, we identified interactions with members of a putative dynein arm assembly complex. These include the ciliary intraflagellar transport protein IFT88 and the AAA+ (ATPases Associated with various cellular Activities) family proteins RUVBL1 (Pontin) and RUVBL2 (Reptin). Co-localization studies support these findings, with the loss of RUVBL1 perturbing the co-localization of DNAAF1 with IFT88. We show that RUVBL1 orthologues have an asymmetric left-sided distribution at both the mouse embryonic node and the Kupffer’s vesicle in zebrafish embryos, with the latter asymmetry dependent on DNAAF1. These results suggest that DNAAF1-RUVBL1 biochemical and genetic interactions have a novel functional role in symmetry breaking and cardiac development

Potencial ornamental de espécies nativas de Passiflora spp. em fachada verde.

O presente trabalho teve como objetivo avaliar o potencial ornamental das espécies nativas de Passiflora em fachadas verdes na região da Zona da Mata de Pernambuco.Resumo 113

Anti-angiogenic therapy for cancer: Current progress, unresolved questions and future directions

Tumours require a vascular supply to grow and can achieve this via the expression of pro-angiogenic growth factors, including members of the vascular endothelial growth factor (VEGF) family of ligands. Since one or more of the VEGF ligand family is overexpressed in most solid cancers, there was great optimism that inhibition of the VEGF pathway would represent an effective anti-angiogenic therapy for most tumour types. Encouragingly, VEGF pathway targeted drugs such as bevacizumab, sunitinib and aflibercept have shown activity in certain settings. However, inhibition of VEGF signalling is not effective in all cancers, prompting the need to further understand how the vasculature can be effectively targeted in tumours. Here we present a succinct review of the progress with VEGF-targeted therapy and the unresolved questions that exist in the field: including its use in different disease stages (metastatic, adjuvant, neoadjuvant), interactions with chemotherapy, duration and scheduling of therapy, potential predictive biomarkers and proposed mechanisms of resistance, including paradoxical effects such as enhanced tumour aggressiveness. In terms of future directions, we discuss the need to delineate further the complexities of tumour vascularisation if we are to develop more effective and personalised anti-angiogenic therapies. © 2014 The Author(s)