Cave abitate. Recupero di un'area di cava dismessa ubicata ad alta quota nel Parco Regionale delle Alpi Apuane.

none3Si studiano le potenzialità di valorizzazione delle risorse ambientali di un sito di cava : soleggiamento, vento, terreno, materiali abbandonati nei ravaneti, sedimi di cave antiche possono generare le caratteristiche dell'architettura anche ai fini della sostenibilità.Si tratta di una ricerca di sperimentazione progettuale, svolta nel corso di tesi di laurea seguita come relatrice Appartiene alla Fase 2 di un’ampia attività di ricerca sulla Progettazione ambientale alle diverse scale, che utilizza come campo di lavoro il territorio apuano.noneM. Toni; E. Iorio; M. LovisattiToni, Michela Maria; E., Iorio; M., Lovisatt

[Radiologic approach to endocrine pathology in childhood]

The new imaging techniques (ultrasound, CT, digital subtraction angiography) have greatly modified the diagnostic approach to the endocrinopathies in pediatric age, notably if of surgical interest. The main clinical indications to the ultrasound and/or CT study of hypophysis, thyroid, adrenals and female internal genital tract are synthesized in this paper. A diagnostic flow-chart is also suggested for each clinical entity

Direct measurement of the lumped constant for 2-deoxy-[1-(14)C]glucose in vivo in human skeletal muscle

The lumped constant (LC) is used to convert the clearance rate of 2-deoxy-D-glucose (2-DG(CR)) to that of glucose (Glc(CR)). There are currently no data to validate the widely used assumption of an LC of 1.0 for human skeletal muscle. We determined the LC for 2-deoxy-[1-(14)C]glucose (2-DG) in 18 normal male subjects (age, 29+/- 2 yr; body mass index, 24.8+/-0.8 kg/m(2)) after an overnight fast and during physiological (1 mU x kg(-1) x min(-1) insulin infusion for 180 min) and supraphysiological (5 mU x kg(-1) x min(-1) insulin infusion for 180 min) hyperinsulinemic conditions. Normoglycemia was maintained with the euglycemic clamp technique. The LC was measured directly with the use of a novel triple tracer-based method. [3-(3)H]glucose, 2-[1-(14)C]DG, and [(12)C]mannitol (Man) were injected as a bolus into the brachial artery. The concentrations of [3-(3)H]glucose and 2-[1-(14)C]DG (dpm/ml plasma) and of Man (micromol/l) were determined in 50 blood samples withdrawn from the ipsilateral deep forearm vein over 15 min after the bolus injection. The LC was calculated by a formula involving blood flow calculated from Man and the Glc(CR) and 2-DG(CR). The LC averaged 1.26+/-0.08 (range 1.06-1.43), 1.15+/-0.05 (0.99-1.39), and 1.18+/-0.05 (0.97-1.37) under fasting conditions and during the 1 and 5 mU x kg(-1). min(-1) insulin infusions (not significant between the different insulin concentrations, mean LC = 1.2, P<0.01 vs. 1.0). We conclude that, in normal subjects, the LC for 2-DG in human skeletal muscle is constant over a wide range of insulin concentrations and averages 1. 2

Direct measurement of the lumped constant for 2-deoxy-[1-¹⁴C]glucose in vivo in human skeletal muscle

The lumped constant (LC) is used to convert the clearance rate of 2-deoxy-d-glucose (2-DGcr) to that of glucose (Glccr). There are currently no data to validate the widely used assumption of an LC of 1.0 for human skeletal muscle. We determined the LC for 2-deoxy-[1-14C]glucose (2-DG) in 18 normal male subjects (age, 29 ± 2 yr; body mass index, 24.8 ± 0.8 kg/m2) after an overnight fast and during physiological (1 mU · kg−1· min−1insulin infusion for 180 min) and supraphysiological (5 mU · kg−1· min−1insulin infusion for 180 min) hyperinsulinemic conditions. Normoglycemia was maintained with the euglycemic clamp technique. The LC was measured directly with the use of a novel triple tracer-based method. [3-3H]glucose, 2-[1-14C]DG, and [12C]mannitol (Man) were injected as a bolus into the brachial artery. The concentrations of [3-3H]glucose and 2-[1-14C]DG (dpm/ml plasma) and of Man (μmol/l) were determined in 50 blood samples withdrawn from the ipsilateral deep forearm vein over 15 min after the bolus injection. The LC was calculated by a formula involving blood flow calculated from Man and the Glccrand 2-DGcr. The LC averaged 1.26 ± 0.08 (range 1.06–1.43), 1.15 ± 0.05 (0.99–1.39), and 1.18 ± 0.05 (0.97–1.37) under fasting conditions and during the 1 and 5 mU · kg−1· min−1insulin infusions (not significant between the different insulin concentrations, mean LC = 1.2, P &lt; 0.01 vs. 1.0). We conclude that, in normal subjects, the LC for 2-DG in human skeletal muscle is constant over a wide range of insulin concentrations and averages 1.2.</jats:p