The role of inflammation in epilepsy.

Epilepsy is the third most common chronic brain disorder, and is characterized by an enduring predisposition to generate seizures. Despite progress in pharmacological and surgical treatments of epilepsy, relatively little is known about the processes leading to the generation of individual seizures, and about the mechanisms whereby a healthy brain is rendered epileptic. These gaps in our knowledge hamper the development of better preventive treatments and cures for the approximately 30% of epilepsy cases that prove resistant to current therapies. Here, we focus on the rapidly growing body of evidence that supports the involvement of inflammatory mediators-released by brain cells and peripheral immune cells-in both the origin of individual seizures and the epileptogenic process. We first describe aspects of brain inflammation and immunity, before exploring the evidence from clinical and experimental studies for a relationship between inflammation and epilepsy. Subsequently, we discuss how seizures cause inflammation, and whether such inflammation, in turn, influences the occurrence and severity of seizures, and seizure-related neuronal death. Further insight into the complex role of inflammation in the generation and exacerbation of epilepsy should yield new molecular targets for the design of antiepileptic drugs, which might not only inhibit the symptoms of this disorder, but also prevent or abrogate disease pathogenesis

Italian guidelines for primary headaches: 2012 revised version

The first edition of the Italian diagnostic and therapeutic guidelines for primary headaches in adults was published in J Headache Pain 2(Suppl. 1):105–190 (2001). Ten years later, the guideline committee of the Italian Society for the Study of Headaches (SISC) decided it was time to update therapeutic guidelines. A literature search was carried out on Medline database, and all articles on primary headache treatments in English, German, French and Italian published from February 2001 to December 2011 were taken into account. Only randomized controlled trials (RCT) and meta-analyses were analysed for each drug. If RCT were lacking, open studies and case series were also examined. According to the previous edition, four levels of recommendation were defined on the basis of levels of evidence, scientific strength of evidence and clinical effectiveness. Recommendations for symptomatic and prophylactic treatment of migraine and cluster headache were therefore revised with respect to previous 2001 guidelines and a section was dedicated to non-pharmacological treatment. This article reports a summary of the revised version published in extenso in an Italian version

Rockslides and rock avalanches in the Central Andes of Argentina and their possible association with permafrost degradation

The identification of hazardous slopes with degrading permafrost is a key task in the mountain periglacial environment. If rockslides have previously been preconditioned by rock wall permafrost, similar events may be triggered from present unstable rock walls. An inventory of rockslides and rock avalanches in the austral part of the Santa Cruz river basin (31°40′–31°50′S, 70°30′–70°10’W), San Juan, Argentina, was made. The study area comprises a surface of approximately 432 km2 (50% above 3,500 m asl); 15 rockslides, 12 complex rockslides evolving to rock avalanches and 19 rock avalanches were identified. The deposits were analyzed with remote sensory imagery and during fieldwork in order to study processes under permafrost degradation caused by global warming. Rock sampling procedures and laboratory rock-resistivity testing were also carried out. We characterized the detachment scars and deposits for two rockslides. Two different mechanisms were identified. In one rockslide, shallow active layer detachment was favored by shear-displacement along pre-existing joints, as a result of short-term periods of climate warming. In the other, long-term permafrost degradation favored a deeper failure process. The studied landslide processes could not be explained by permafrost degradation alone. Faults, the geometric arrangement of their structural elements and seismic activity may contribute to trigger these phenomena. It is expected that the magnitude and frequency of rockslide hazards will increase during the 21st century.Fil: Tapia Baldis, Carla Cintia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto Argentino de Nivología, Glaciología y Ciencias Ambientales. Provincia de Mendoza. Instituto Argentino de Nivología, Glaciología y Ciencias Ambientales. Universidad Nacional de Cuyo. Instituto Argentino de Nivología, Glaciología y Ciencias Ambientales; ArgentinaFil: Trombotto, Dario Tomas. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto Argentino de Nivología, Glaciología y Ciencias Ambientales. Provincia de Mendoza. Instituto Argentino de Nivología, Glaciología y Ciencias Ambientales. Universidad Nacional de Cuyo. Instituto Argentino de Nivología, Glaciología y Ciencias Ambientales; Argentin