The ecology of the intestinal flora in a changing environment Final report

Resume of publications and recommendations from symposium on intestinal flora ecology in changing environment

Research on long term biological isolation of primates and mice. Volume 4 - The literature search, appendix M Final report

Literature search for effects of intestinal microflora on host organism

Energy and Nutrient Intake Monitoring

A passive system to determine the in-flight intake of nutrients is developed. Nonabsorbed markers placed in all foods in proportion to the nutrients selected for study are analyzed by neutron activation analysis. Fecal analysis for each market indicates how much of the nutrients were eaten and apparent digestibility. Results of feasibility tests in rats, mice, and monkeys indicate the diurnal variation of several markers, the transit time for markers in the alimentary tract, the recovery of several markers, and satisfactory use of selected markers to provide indirect measurement of apparent digestibility. Recommendations are provided for human feasibility studies

Comparison between high-energy proton and charged pion induced damage in Lead Tungstate calorimeter crystals

A Lead Tungstate crystal produced for the electromagnetic calorimeter of the CMS experiment at the LHC was cut into three equal-length sections. The central one was irradiated with 290 MeV/c positive pions up to a fluence of (5.67 +- 0.46)x10^13 /cm^2, while the other two were exposed to a 24 GeV/c proton fluence of (1.17 +- 0.11) x 10^13/ cm^2. The damage recovery in these crystals, stored in the dark at room temperature, has been followed over two years. The comparison of the radiation-induced changes in light transmission for these crystals shows that damage is proportional to the star densities produced by the irradiation.Comment: 7 pages, 4 figure

First results on radiation damage in PbWO4 crystals exposed to a 20 GeV/c proton beam

We have exposed seven full length production quality crystals of the electromagnetic calorimeter (ECAL) of the CMS detector to a 20 GeV/c proton beam at the CERN PS accelerator. The exposure was done at fluxes of 10**12 p/cm**2/h and 10**13 p/cm**2/h and integral fluences of 10**12 p/cm**2 and 10**13 p/cm**2 were reached at both rates. The light transmission of the crystals was measured after irradiation and suitable cooling time for induced radioactivity to decrease to a safe level. First results of these measurements are shown. The possible damage mechanisms are discussed and simulations based on one possible model are presented. The implications for long-term operation of CMS are discussed and it is shown that in the whole barrel and at least most of the ECAL endcap hadron damage alone - even if cumulative - should not cause the crystals to fail the CMS specification of an induced absorption coefficient muIND < 1.5 /m during the first 10 years of LHC operation.Comment: 5 pages, to be published in Proc. ICATPP Conference on Astroparticle, Particle, Space Physics, Detectors and Medical Physics Applications (Como, Italy, 6 to 10 October 2003

An evaluation of nutritional markers, volume 2

Use of nutritional markers for studies of food intake, passage, and absorption in gastrointestinal track of humans and animal

Research on long term biological isolation of primates and mice, volume 1 Final report, 7 Jan. 1969 - 7 Jan. 1970

Long term effects of biological isolation on monkeys and mice with application to prolonged space fligh

Performance studies of scintillating ceramic samples exposed to ionizing radiation

Scintillating ceramics are a promising, new development for various applications in science and industry. Their application in calorimetry for particle physics experiments is expected to involve an exposure to high levels of ionizing radiation. In this paper, changes in performance have been measured for scintillating ceramic samples of different composition after exposure to penetrating ionizing radiation up to a dose of 38 kGy.Comment: 6 pages, 8 figures, to be published in the 2012 IEEE Nuclear Science Symposium Conference Recor

A visualization of the damage in Lead Tungstate calorimeter crystals after exposure to high-energy hadrons

The anticipated performance of calorimeter crystals in the environment expected after the planned High-Luminosity upgrade of the Large Hadron Collider (HL-LHC) at CERN has to be well understood, before informed decisions can be made on the need for detector upgrades. Throughout the years of running at the HL-LHC, the detectors will be exposed to considerable fluences of fast hadrons, that have been shown to cause cumulative transparency losses in Lead Tungstate scintillating crystals. In this study, we present direct evidence of the main underlying damage mechanism. Results are shown from a test that yields a direct insight into the nature of the hadron-specific damage in Lead Tungstate calorimeter crystals exposed to 24 GeV/c protons.Comment: 8 pages, 6 figure

The newly developed CRF1-receptor antagonists, NGD 98-2 and NGD 9002, suppress acute stress-induced stimulation of colonic motor function and visceral hypersensitivity in rats.

Corticotropin releasing factor receptor 1 (CRF1) is the key receptor that mediates stress-related body responses. However to date there are no CRF1 antagonists that have shown clinical efficacy in stress-related diseases. We investigated the inhibitory effects of a new generation, topology 2 selective CRF1 antagonists, NGD 98-2 and NGD 9002 on exogenous and endogenous CRF-induced stimulation of colonic function and visceral hypersensitivity to colorectal distension (CRD) in conscious rats. CRF1 antagonists or vehicle were administered orogastrically (og) or subcutaneously (sc) before either intracerebroventricular (icv) or intraperitoneal (ip) injection of CRF (10 µg/kg), exposure to water avoidance stress (WAS, 60 min) or repeated CRD (60 mmHg twice, 10 min on/off at a 30 min interval). Fecal pellet output (FPO), diarrhea and visceromotor responses were monitored. In vehicle (og)-pretreated rats, icv CRF stimulated FPO and induced diarrhea in &gt;50% of rats. NGD 98-2 or NGD 9002 (3, 10 and 30 mg/kg, og) reduced the CRF-induced FPO response with an inhibitory IC50 of 15.7 and 4.3 mg/kg respectively. At the highest dose, og NGD 98-2 or NGD 9002 blocked icv CRF-induced FPO by 67-87% and decreased WAS-induced-FPO by 23-53%. When administered sc, NGD 98-2 or NGD 9002 (30 mg/kg) inhibited icv and ip CRF-induced-FPO. The antagonists also prevented the development of nociceptive hyper-responsivity to repeated CRD. These data demonstrate that topology 2 CRF1 antagonists, NGD 98-2 and NGD 9002, administered orally, prevented icv CRF-induced colonic secretomotor stimulation, reduced acute WAS-induced defecation and blocked the induction of visceral sensitization to repeated CRD