MySpace or OurSpace: a Cross-Cultural Empirical Analysis of MySpace Comments

The goal of the current study was to compare users from two distinct cultures to examine the extent to which they communicate differently through MySpace comments and to see how such differences might relate to their cultural background and biological sex. For this purpose, Hofstede\u27s theories of individualism/collectivism and masculinity/femininity and Ting-Toomey\u27s face negotiation theory were used as frameworks. Content analysis was performed on 150 Hungarian and 150 American randomly selected MySpace comments. One-way ANOVAs and crosstabulations showed some significant differences and similarities between Hungarian and American MySpace comments. Real-life cultural differences and sex-linked differences were found to be reflected in the comments. Thus, this study found mixed evidence for the existence of a global MySpace culture that includes both global linguistic features and reflects upon elements from users\u27 own traditional cultur

Development of new inhibitors for the enzymes dimethylarginine dimethylaminohydrolase and arginase

Diese Arbeit umfasst unterschiedliche Synthesen und Testungen neuer Inhibitoren der Enzyme Dimethylarginin Dimethylaminohydrolase (DDAH) und ArginaseThis work covers diverse syntheses and tests of new inhibitors of the enzymes dimethylarginine dimethylaminohydrolase (DDAH) and arginas

Sárospataki Kistérség

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Experiments on the longitudinal ion momentum balance in a magnetized plasma

In the magnetized plasma of a hollow cathode arc the longitudinal and rotational drift velocities of ions have been measured, together with the electron and neutral densities and the temperatures of ions, electrons, and neutrals. The radial and longitudinal gradients of these quantities have been established. The ions drift against the electric field towards the anode with velocities between about 500 and 2500 m/s, driven by the plasma pressure gradient which is balanced by viscous deceleration and by friction against the surrounding neutral gas. The classical theory of the momentum balance with a turbulent contribution to the viscosity provides a good description of the longitudinal ion transport and explains direction and magnitude of the occurring drift velocity

The rotation of ions and neutrals in a cylindrical magnetized hollow cathode argon arc

In a magnetized hollow cathode arc rotational velocities of ions and neutrals and their temperatures were measured in axial and radial dependence. In comparison with theory experimental results give a detailed analysis of radial transport phenomen

Pendampingan desain masterplan pengembangan masjid Nurul Huda dusun Mentokan, desa Darek kabupaten Lombok Tengah

AbstrakMasjid merupakan tempat ibadah yang juga berfungsi sebagai pusat kegiatan sosial dan pendidikan. Dalam konteks Masjid Nurul Huda di Dusun Mentokan, Desa Darek, Kabupaten Lombok Tengah, terdapat kebutuhan untuk pengembangan fasilitas akibat meningkatnya jumlah penduduk dan kondisi bangunan yang sudah tua. Tim pengabdian dari Program Studi Teknik Sipil Universitas Muhammadiyah melakukan pendampingan desain masterplan untuk merespons kebutuhan tersebut. Metodologi yang digunakan mencakup pengumpulan data, analisis kebutuhan, dan perancangan konsep, dengan melibatkan masyarakat dalam setiap tahap. Hasilnya menunjukkan bahwa masyarakat menginginkan ruang multifungsi untuk kegiatan pendidikan dan sosial. Selain itu, masterplan yang dihasilkan juga mempertimbangkan aspek keberlanjutan dengan memanfaatkan sumber daya secara efisien. Partisipasi masyarakat dalam perencanaan terbukti meningkatkan rasa memiliki dan tanggung jawab terhadap masjid, sehingga diharapkan masjid tidak hanya berfungsi sebagai tempat ibadah, tetapi juga sebagai pusat kegiatan yang bermanfaat bagi komunitas. Kata kunci: masjid; pengabdian kepada masyarakat; masterplane. AbstractMosques are places of worship that also function as centers for social and educational activities. In the context of the Nurul Huda Mosque in Mentokan Hamlet, Darek Village, Central Lombok Regency, there is a need for the development of facilities due to the increasing population and the condition of the old building. The service team from the Civil Engineering Study Program, University of Muhammadiyah assisted in the design of a master plan to respond to these needs. The methodology used includes data collection, needs analysis, and concept design, by involving the community at every stage. The results show that the community wants a multifunctional space for educational and social activities. In addition, the resulting masterplan also considers sustainability aspects by utilizing resources efficiently. Community participation in planning has been proven to increase the sense of ownership and responsibility for the mosque, so it is hoped that the mosque will not only function as a place of worship, but also as a center of activities that are beneficial to the community. Keywords: mosque; community service; masterplane

Electroanatomical voltage mapping with contact force sensing for diagnosis of arrhythmogenic right ventricular cardiomyopathy

Background Three-dimensional electroanatomical mapping (EAM) can be helpful to diagnose arrhythmogenic right ventricular cardiomyopathy (ARVC). Yet, previous studies utilizing EAM have not systematically used contact-force sensing catheters (CFSC) to characterize the substrate in ARVC, which is the current gold standard to assure adequate tissue contact. Objective To investigate reference values for endocardial right ventricular (RV) EAM as well as substrate characterization in patients with ARVC by using CFSC. Methods Endocardial RV EAM during sinus rhythm was performed with CFSC in 12 patients with definite ARVC and 5 matched controls without structural heart disease. A subanalysis for the RV outflow tract (RVOT), septum, free-wall, subtricuspid region, and apex was performed. Endocardial bipolar and unipolar voltage amplitudes (BVA, UVA), signal characteristics and duration as well as the impact of catheter orientation on endocardial signals were also investigated. Results ARVC patients showed lower BVA vs. controls (p = 0.018), particularly in the subtricuspid region (1.4, IQR:0.5–3.1 vs. 3.8, IQR:2.5-5 mV, p = 0.037) and RV apex (2.5, IQR:1.5–4 vs. 4.3,IQR:2.9–6.1 mV, p = 0.019). BVA in all RV regions yielded a high sensitivity and specificity for ARVC diagnosis (AUC 59–78%, p < 0.05 for all), with the highest performance for the subtricuspid region (AUC 78%, 95% CI:0.75–0.81, p < 0.001, negative predictive value 100%). A positive correlation between BVA and an orthogonal catheter orientation (46°-90°:r = 0.106, p < 0.001), and a negative correlation between BVA and EGM duration (r = −0.370, p < 0.001) was found. Conclusions EAM using CFSC validates previous bipolar cut-off values for normal endocardial RV voltage amplitudes. RV voltages are generally lower in ARVC as compared to controls, with the subtricuspid area being commonly affected and having the highest discriminatory power to differentiate between ARVC and healthy controls. Therefore, EAM using CFSC constitutes a promising tool for diagnosis of ARVC

Efficacy, safety, and injection frequency with novel aflibercept 8 mg in neovascular age-related macular degeneration: a comparison with existing anti-VEGF regimens using a Bayesian network meta-analysis

Introduction: Aflibercept 8 mg administered in extended dosing intervals has shown non-inferior visual gains and comparable safety profile to aflibercept 2 mg in the PULSAR pivotal randomized clinical trial and has the potential to reduce the treatment burden of treating neovascular age-related macular degeneration (nAMD). This study aimed at gathering robust evidence to assess the comparative efficacy, safety, and treatment burden of aflibercept 8 mg against other anti-vascular endothelial growth factor (VEGF) agents as ranibizumab, brolucizumab, faricimab, and bevacizumab in patients with nAMD. Methods: A systematic literature review (SLR) was conducted, targeting clinical trials of anti-VEGF agents in patients with nAMD. The results of the SLR were included in a network meta-analysis (NMA) comparing aflibercept 8 mg to other anti-VEGF treatments in nAMD, considering a 1-year time horizon. Treatment efficacy was assessed based on the change in best-corrected visual acuity (BCVA) from baseline, the proportion of patients gaining or losing 15 Early Treatment Diabetic Retinopathy Study (ETDRS) letters and changes in anatomical outcomes measured as change in central retinal thickness (CRT) or central subfield thickness (CST). Safety was assessed considering the incidence of ocular and non-ocular adverse events. Treatment burden was defined as the mean number of intravitreal injections over the study period. Results: The base-case NMA involving 21 studies did not show significant differences between aflibercept 8 mg and comparators regarding BCVA change from baseline and proportion of patients with a gain or loss of ≥ 15 letters. On the anatomical endpoints, aflibercept 8 mg was associated with statistically significant improvement in CRT/CST change from baseline compared with ranibizumab in fixed and pro re nata regimens. No significant differences were identified versus the other anti-VEGF. The analysis of the safety outcomes did not identify any significant differences between aflibercept 8 mg and any of the comparators. During the first year of treatment, patients treated with aflibercept 8 mg (following 12- or 16-week injection intervals) received on average 5.9 and 5.1 injections, respectively. For the same period, patients treated with faricimab received from 6.2 to 6.7 injections, patients treated with ranibizumab from 7.62 to 12.14 injections, and patients treated with aflibercept 2 mg up to 7.67 injections. Conclusion: Aflibercept 8 mg demonstrates a comparable efficacy and safety to currently available anti-VEGF treatments for nAMD, with the potential added benefit of requiring fewer injections. These results suggest that aflibercept 8 mg could be a favourable treatment option for nAMD, achieving sustained disease control while alleviating the burden of injections on patients, caregivers, and healthcare providers