Distintos aspectos del tributo entre los Yauyos de Chaclla (siglos XV-XVIII)

Fil: Gentile Lafaille, Margarita E.. Museo de La Plata. Universidad Nacional de La Plata; Argentin

Los Yauyos de Chaclla: pueblos y ayllus (siglo XVIII)

Fil: Gentile Lafaille, Margarita E.. Museo de La Plata. Universidad Nacional de La Plata; Argentin

Ageing of polysulfone membranes in contact with bleach solution: Role of radical oxidation and of some dissolved metal ions

In water production plants using membrane processes, contact with chemicals such as chlorine plays an important role in membrane ageing. This experimental study was aimed at gaining a better understanding of the effect of hypochlorite cleaning solutions on the properties of a polysulfone ultrafiltration membrane. Accelerated ageing of the membrane was simulated by soaking it in chlorine solutions and the mechanical properties of the membrane were monitored versus soaking time. An oxidation mechanism is validated which involves the catalytic effect of dissolved metal ions and the inhibitor effect of an antioxidant when these are present in soaking solutions

Los espacios jurídicos de las identidades étnicas en el área andina argentina: las tres repúblicas en el siglo XVI

Fil: Gentile Lafaille, Margarita E.. Museo de La Plata. Universidad Nacional de La Plata; Argentin

Uso ceremonial de cabezas humanas en Nasca : una pieza del Museo de Arte de Lima

Fil: Gentile Lafaille, Margarita E.. Museo de La Plata. Universidad Nacional de La Plata; Argentin

Swift development of protective effector functions in naive CD8(+) T cells against malaria liver stages.

We generated T cell receptor transgenic mice specific for the liver stages of the rodent malaria parasite Plasmodium yoelii and studied the early events in the development of in vivo effector functions in antigen-specific CD8(+) T cells. Differently to activated/memory cells, naive CD8(+) T cells are not capable of exerting antiparasitic activity unless previously primed by parasite immunization. While naive cells need to differentiate before achieving effector status, the time required for this process is very short. Indeed, interferon (IFN)-gamma and perforin mRNA are detectable 24 h after immunization and IFN-gamma secretion and cytotoxic activity are detected ex vivo 24 and 48 h after immunization, respectively. In contrast, the proliferation of CD8(+) T cells begins after 24 h and an increase in the total number of antigen-specific cells is detected only after 48 h. Remarkably, a strong CD8(+) T cell-mediated inhibition of parasite development is observed in mice challenged with viable parasites only 24 h after immunization with attenuated parasites. These results indicate that differentiation of naive CD8(+) T cells does not begin only after extensive cell division, rather this process precedes or occurs simultaneously with proliferation

Notas sobre algunas mujeres del Collasuyu (siglos XV al XVIII)

Fil: Gentile Lafaille, Margarita E.. Museo de La Plata. Universidad Nacional de La Plata; Argentin

Los mates pirograbados de la cuenca del Río Doncellas

Fil: Alfaro, Lidia. Fil: Gentile Lafaille, Margarita E.. Academia Nacional de la Historia; Per

Statistical inference of the generation probability of T-cell receptors from sequence repertoires

Stochastic rearrangement of germline DNA by VDJ recombination is at the origin of immune system diversity. This process is implemented via a series of stochastic molecular events involving gene choices and random nucleotide insertions between, and deletions from, genes. We use large sequence repertoires of the variable CDR3 region of human CD4+ T-cell receptor beta chains to infer the statistical properties of these basic biochemical events. Since any given CDR3 sequence can be produced in multiple ways, the probability distribution of hidden recombination events cannot be inferred directly from the observed sequences; we therefore develop a maximum likelihood inference method to achieve this end. To separate the properties of the molecular rearrangement mechanism from the effects of selection, we focus on non-productive CDR3 sequences in T-cell DNA. We infer the joint distribution of the various generative events that occur when a new T-cell receptor gene is created. We find a rich picture of correlation (and absence thereof), providing insight into the molecular mechanisms involved. The generative event statistics are consistent between individuals, suggesting a universal biochemical process. Our distribution predicts the generation probability of any specific CDR3 sequence by the primitive recombination process, allowing us to quantify the potential diversity of the T-cell repertoire and to understand why some sequences are shared between individuals. We argue that the use of formal statistical inference methods, of the kind presented in this paper, will be essential for quantitative understanding of the generation and evolution of diversity in the adaptive immune system.Comment: 20 pages, including Appendi

La productique en Ile-de-France. Innovations, recherche et transferts de technologie vers les PMI (1988)

L'étude propose de suivre un triple objectif : 1- Contribuer à l'inventaire et à l'évaluation des intervenants en productique dans la région francilienne, dans ses aspects tant quantitatifs que qualitatifs (industriels et laboratoires de recherche) ; 2- Evaluer la manière dont les tissus industriels franciliens sont pénétrés par la productique ; 3- Formuler des propositions, adressées notamment au Conseil Régional de l'Ile-de-France (IdF) pour une politique de développement de la productique.Cette étude a été réalisée dans le cadre de la convention de recherche du 2 février 1988 passée entre le Centre Régional d'Innovation et de Transfert Technologique en Mécanique d'Ile-de-France (CRITT MECA) et le Laboratoire de Recherche et d'Etude sur les Mutations Industrielles du Centre de Robotique Intégrée d'Ile-de-France (LAREMI/CRIIF – Ministère de la recherche) pendant le premier semestre de l'année 1988