Neurological manifestations of COVID-19 in adults and children

Different neurological manifestations of coronavirus disease 2019 (COVID-19) in adults and children and their impact have not been well characterized. We aimed to determine the prevalence of neurological manifestations and in-hospital complications among hospitalized COVID-19 patients and ascertain differences between adults and children. We conducted a prospective multicentre observational study using the International Severe Acute Respiratory and emerging Infection Consortium (ISARIC) cohort across 1507 sites worldwide from 30 January 2020 to 25 May 2021. Analyses of neurological manifestations and neurological complications considered unadjusted prevalence estimates for predefined patient subgroups, and adjusted estimates as a function of patient age and time of hospitalization using generalized linear models. Overall, 161 239 patients (158 267 adults; 2972 children) hospitalized with COVID-19 and assessed for neurological manifestations and complications were included. In adults and children, the most frequent neurological manifestations at admission were fatigue (adults: 37.4%; children: 20.4%), altered consciousness (20.9%; 6.8%), myalgia (16.9%; 7.6%), dysgeusia (7.4%; 1.9%), anosmia (6.0%; 2.2%) and seizure (1.1%; 5.2%). In adults, the most frequent in-hospital neurological complications were stroke (1.5%), seizure (1%) and CNS infection (0.2%). Each occurred more frequently in intensive care unit (ICU) than in non-ICU patients. In children, seizure was the only neurological complication to occur more frequently in ICU versus non-ICU (7.1% versus 2.3%, P < 0.001). Stroke prevalence increased with increasing age, while CNS infection and seizure steadily decreased with age. There was a dramatic decrease in stroke over time during the pandemic. Hypertension, chronic neurological disease and the use of extracorporeal membrane oxygenation were associated with increased risk of stroke. Altered consciousness was associated with CNS infection, seizure and stroke. All in-hospital neurological complications were associated with increased odds of death. The likelihood of death rose with increasing age, especially after 25 years of age. In conclusion, adults and children have different neurological manifestations and in-hospital complications associated with COVID-19. Stroke risk increased with increasing age, while CNS infection and seizure risk decreased with age

Fouilles des PP. Vincent et Carrière près de Jéricho

Lagrange Marie-Joseph. Fouilles des PP. Vincent et Carrière près de Jéricho. In: Comptes rendus des séances de l'Académie des Inscriptions et Belles-Lettres, 65ᵉ année, N. 2, 1921. p. 201

Compte rendu d'une mission à Mâdaba et du premier déblaiement de la mosaïque d'Orphée à Jérusalem

Lagrange Marie-Joseph. Compte rendu d'une mission à Mâdaba et du premier déblaiement de la mosaïque d'Orphée à Jérusalem. In: Comptes rendus des séances de l'Académie des Inscriptions et Belles-Lettres, 45ᵉ année, N. 4, 1901. pp. 571-574

Rapport sur une exploration archéologique au Négeb

Lagrange Marie-Joseph. Rapport sur une exploration archéologique au Négeb. In: Comptes rendus des séances de l'Académie des Inscriptions et Belles-Lettres, 48ᵉ année, N. 3, 1904. pp. 279-305

Un sanctuaire d'Allat à Iram

Lagrange Marie-Joseph. Un sanctuaire d'Allat à Iram. In: Comptes rendus des séances de l'Académie des Inscriptions et Belles-Lettres, 76ᵉ année, N. 3, 1932. pp. 225-227

Deux hypogées macédo-sidoniens à Beit-Djebrîn (Palestine)

Lagrange Marie-Joseph. Deux hypogées macédo-sidoniens à Beit-Djebrîn (Palestine). In: Comptes rendus des séances de l'Académie des Inscriptions et Belles-Lettres, 46ᵉ année, N. 5, 1902. pp. 497-505

Nouvelles des fouilles à 'Aïn Doûq par les PP. Vincent, Carrière et Savignac

Lagrange Marie-Joseph. Nouvelles des fouilles à 'Aïn Doûq par les PP. Vincent, Carrière et Savignac. In: Comptes rendus des séances de l'Académie des Inscriptions et Belles-Lettres, 65ᵉ année, N. 2, 1921. pp. 141-142

Un sanctuaire lihyanite

Lagrange Marie-Joseph. Un sanctuaire lihyanite. In: Comptes rendus des séances de l'Académie des Inscriptions et Belles-Lettres, 53ᵉ année, N. 6, 1909. pp. 457-461