Richtags: Cross Repository Browsing

richtags allows you to search across multiple repositories from numerous institutions covering hundreds of disciplines for research that is of interest to you

Orchestrating musical (meta)data to better address the real-world search queries of musicologists

The dispersal of musicology’s diverse array of primary and secondary sources across countless libraries and archives was once an enormous obstacle to conducting research, but this has largely been overcome by the digitisation and online publication of resources in recent years. Yet, while the research process has undoubtedly been revolutionised, the current situation is far from perfect, as the digitisation of resources has often been accompanied by their segregation—according to media type, date of publication, subject, language, copyright holder, etc.—into a myriad of discrete online repositories, often with little thought having been given to interoperability. Given that musicological research typically cuts across such artificial divisions, this segregation of data means that accessing basic factual information or running multi-part search queries remains endlessly complicated, needlessly time consuming, and sometimes impossible. This barrier to tractability is only exacerbated by the limited capabilities of currently deployed search interfaces. There is one seemingly obvious solution to this query dilemma: enable integrated real-time querying over all the available metadata from as many sources as possible, and allow users to use that metadata to guide their queries. This solution implies that all data that could feasibly be construed as useful, but which is buried in the records, is extracted in some way, and that there is an interaction approach that enables metadata to be explored effectively and allows for the formulation of rich compound queries. The musicSpace project has taken a dual approach towards realising this solution. At the back-end we are developing services to integrate and, where necessary, surface (meta)data from many of musicology’s most important online resources, including the British Library Music Collections catalogue, the British Library Sound Archive catalogue, Cecilia, Copac, Grove Music Online, Naxos Music Library, Répertoire International de Littérature Musicale (RILM), and Répertoire International des Sources Musicale (RISM) UK and Ireland. While at the front-end, in order to optimise the exploration of this integrated dataset, we are developing a modern web-based faceted browsing interface that utilises Semantic Web and Web2.0 technologies such as RDF and AJAX, and which is based on the existing ‘mSpace’ codebase. Our poster outlines the approach we have taken to importing, enriching and integrating the metadata provided by our data partners, and gives examples of the real-world musicological research questions that musicSpace has enabled

Integrating musicology's heterogeneous data sources for better exploration

Musicologists have to consult an extraordinarily heterogeneous body of primary and secondary sources during all stages of their research. Many of these sources are now available online, but the historical dispersal of material across libraries and archives has now been replaced by segregation of data and metadata into a plethora of online repositories. This segregation hinders the intelligent manipulation of metadata, and means that extracting large tranches of basic factual information or running multi-part search queries is still enormously and needlessly time consuming. To counter this barrier to research, the “musicSpace” project is experimenting with integrating access to many of musicology’s leading data sources via a modern faceted browsing interface that utilises Semantic Web and Web2.0 technologies such as RDF and AJAX. This will make previously intractable search queries tractable, enable musicologists to use their time more efficiently, and aid the discovery of potentially significant information that users did not think to look for. This paper outlines our work to date

Exploring patient characteristics and barriers to Hepatitis C treatment in patients on opioid substitution treatment (OST) attending a community based fibro-scanning clinic.

Background and Objectives: Hepatitis C virus (HCV) infection is a major public health issue. There is substandard uptake in HCV assessment and treatment among people who inject drugs (PWID). Community fibroscanning is used to assess disease severity and target treatment. Methods: A survey was administered to a cohort of chronically HCV infected patients attending a community fibroscanning clinic. Questions targeted diagnosis of HCV, suitability, willingness and barriers to engagement in treatment. Descriptive and regression analysis, with thematic analysis of open-ended data was conducted. Results: There was high acceptance of community fibroscanning among this cohort with over 90% (68) attending. High levels of unemployment (90%) and homelessness (40%) were identified. Most patients were on methadone treatment and had been HCV infected for greater than 10 years with length of time since HCV diagnosis being significantly longer in patients with fibroscan scores > 8.5 kPa (P = 0.016). With each unit increase in methadone dose, the odds of the >8.5 fibroscan group increased by 5.2%. Patient identified barriers to engagement were alcohol and drug use, fear of HCV treatment and liver biopsy, imprisonment, distance to hospital and early morning appointments. Conclusion: The study highlights the usefulness of community fibroscanning. Identifying barriers to treatment in this cohort affords an opportunity to increase the treatment uptake. The availability of afternoon clinics and enhanced prison linkage are warranted

Buprenorphine-Naloxone in the Treatment of Codeine Dependence: a Scoping Review of Clinical Case Presentations

Misuse of prescribed and over the counter (OTC) codeine containing medicines is an increasing public health concern in recent times. Studies have called for low threshold treatment services for individuals experiencing codeine dependence using buprenorphine naloxone therapy. We present a scoping review of clinical case presentation literature on the use of buprenorphine-naloxone in the treatment of codeine dependence. Seven records (four single case studies and three case series) on codeine dependence treated with buprenorphine-naloxone were included. Five themes emerged following a review of the cases for the treatment of codeine dependence with buprenorphine-naloxone. They are: (1) Patient Profiles; (2) History of Codeine Misuse; (3) Medical Problems; (4) Use of Other Substances; and (5) Buprenorphine-naloxone in the treatment of Codeine Dependence. The review highlights the complexities of patients with regards to pain, psychiatric illness, poly substance use and iatrogenic dependence, with findings encouraging in terms of patient stabilisation and recovery

A review of physical supply and EROI of fossil fuels in China

This paper reviews China’s future fossil fuel supply from the perspectives of physical output and net energy output. Comprehensive analyses of physical output of fossil fuels suggest that China’s total oil production will likely reach its peak, at about 230 Mt/year (or 9.6 EJ/year), in 2018; its total gas production will peak at around 350 Bcm/year (or 13.6 EJ/year) in 2040, while coal production will peak at about 4400 Mt/year (or 91.9 EJ/year) around 2020 or so. In terms of the forecast production of these fuels, there are significant differences among current studies. These differences can be mainly explained by different ultimately recoverable resources assumptions, the nature of the models used, and differences in the historical production data. Due to the future constraints on fossil fuels production, a large gap is projected to grow between domestic supply and demand, which will need to be met by increasing imports. Net energy analyses show that both coal and oil and gas production show a steady declining trend of EROI (energy return on investment) due to the depletion of shallow-buried coal resources and conventional oil and gas resources, which is generally consistent with the approaching peaks of physical production of fossil fuels. The peaks of fossil fuels production, coupled with the decline in EROI ratios, are likely to challenge the sustainable development of Chinese society unless new abundant energy resources with high EROI values can be found

Slx8 removes Pli1-dependent protein-SUMO conjugates including SUMOylated Topoisomerase I to promote genome stability

Peer reviewedPublisher PD

Introducing musicSpace

Musicologists consult a wide variety of data sources in their research, many of which are now available online. However, the segregation of data into numerous discrete repositories, inadequate metadata, insufficient data/search granularity, and poor search UIs are all barriers to the intelligent manipulation of metadata. This means that research questions requiring advanced cross-source filtering on metadata fields or the running of complex multipart search queries have to date been effectively intractable. The experimental ‘musicSpace’ project seeks to enable such questions by integrating access to leading musicological data sources via a faceted browser and by enriching the metadata of our data providers

Phase I study of IMGN901, a CD56-targeting antibody-drug conjugate, in patients with CD56-positive solid tumors.

Background IMGN901 is a CD56-targeting antibody-drug conjugate designed for tumor-selective delivery of the cytotoxic maytansinoid DM1. This phase 1 study investigated the safety, tolerability, pharmacokinetics, and preliminary activity of IMGN901 in patients with CD56-expressing solid tumors. Methods Patients were enrolled in cohorts of escalating IMGN901 doses, administered intravenously, on 3 consecutive days every 21 days. A dose-expansion phase accrued patients with small cell lung cancer (SCLC), Merkel cell carcinoma (MCC), or ovarian cancer. Results Fifty-two patients were treated at doses escalating from 4 to 94 mg/m(2)/day. The maximum tolerated dose (MTD) was determined to be 75 mg/m(2). Dose-limiting toxicities included fatigue, neuropathy, headache or meningitis-like symptoms, chest pain, dyspnea, and myalgias. In the dose-expansion phase (n = 45), seven patients received 75 mg/m(2) and 38 received 60 mg/m(2) for up to 21 cycles. The recommended phase 2 dose (RP2D) was established at 60 mg/m(2) during dose expansion. Overall, treatment-emergent adverse events (TEAEs) were experienced by 96.9 % of all patients, the majority of which were Grade 1 or 2. The most commonly reported Grade 3 or 4 TEAEs were hyponatremia and dyspnea (each 8.2 %). Responses included 1 complete response (CR), 1 clinical CR, and 1 unconfirmed partial response (PR) in MCC; and 1 unconfirmed PR in SCLC. Stable disease was seen for 25 % of all evaluable patients who received doses ≥60 mg/m(2). Conclusions The RP2D for IMGN901 of 60 mg/m(2) administered for 3 consecutive days every 3 weeks was associated with an acceptable tolerability profile. Objective responses were observed in patients with advanced CD56+ cancers

Telephone follow-up of patients after radical prostatectomy : a systematic review

Objective: to assess and summarize the best scientific evidence from randomized controlled clinical trials about telephone follow-up of patients after radical prostatectomy, based on information about how the phone calls are made and the clinical and psychological effects for the individuals who received this intervention. Method: the search was undertaken in the electronic databases Medline, Web of Science, Embase, Cinahl, Lilacs and Cochrane. Among the 368 references found, five were selected. Results: two studies tested interventions focused on psychological support and three tested interventions focused on the physical effects of treatment. The psychoeducative intervention to manage the uncertainty about the disease and the treatment revealed statistically significant evidences and reduced the level of uncertainty and anguish it causes. Conclusion: the beneficial effects of telephone follow-up could be determined, as a useful tool for the monitoring of post-prostatectomy patients.Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)